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ETHYNODIOL-ETHINYL ESTRADIOL (ETHYNODIOL DIACETATE-ETHINYL ESTRADIOL)
- Pregnancy contraception
- Zovia 1/35E (28) Tablet
- Kelnor 1/35 (28) Tablet
- Kelnor 1-50 Tablet
- Ethynodiol Diacetate-ethinyl Estradiol Tablet
- Ethynodiol Diac-eth Estradiol Tablet
- By Indication
1 mg-35 mcg tablet
- 1 tablet by oral route once daily
Zovia 1/35E (28) 1 mg-35 mcg tablet
- 1 tablet by oral route once daily
Kelnor 1/35 (28) 1 mg-35 mcg tablet
- 1 tablet by oral route once daily
1 mg-50 mcg tablet
- 1 tablet by oral route once daily
ethynodiol diacetate-ethinyl estradiol 1 mg-35 mcg tablet
- 1 tablet by oral route once daily
ethynodiol diacetate-ethinyl estradiol 1 mg-50 mcg tablet
- 1 tablet by oral route once daily
ethynodiol diacetate-ethinyl estradiol 1 mg-35 mcg tablet
- 1 tablet by oral route once daily
ethynodiol diacetate-ethinyl estradiol 1 mg-50 mcg tablet
- 1 tablet by oral route once daily
Pregnancy contraception
- 1 tablet by oral route once daily
- anastrozole
- Arimidex
- Aromasin
- Cyklokapron
- exemestane
- Femara
- letrozole
- Lysteda
- sodium tetradecyl sulfate
- Sotradecol
- tranexamic acid
Contraindicated
- Alagesic Lq
- amobarbital
- Amytal
- Aptiom
- Aptivus
- artemether-lumefantrine
- Ascomp With Codeine
- atazanavir
- Atripla
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Banzel
- Belladonna-phenobarbital
- boceprevir
- bosentan
- Brevital
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cellcept
- Cellcept Intravenous
- Cerebyx
- chloramphenicol sod succinate
- clobazam
- Coartem
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- dabrafenib
- darunavir
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- efavirenz
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- Epitol
- Equetro
- Esgic
- eslicarbazepine
- ethotoin
- Fatigue Relief Complex
- felbamate
- Felbatol
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fosamprenavir
- fosphenytoin
- Fycompa
- Grifulvin V
- Gris-peg (ultramicrosize)
- griseofulvin microsize
- griseofulvin ultramicrosize
- Incivek
- Invirase
- isoniazid-rifamp-pyrazinamide
- Kaletra
- Korlym
- Lexiva
- lopinavir-ritonavir
- Luminal
- Margesic
- Marten-tab
- methohexital
- mifepristone
- modafinil
- Mycobutin
- mycophenolate mofetil
- mycophenolate mofetil HCl
- mycophenolate sodium
- Myfortic
- Mysoline
- nelfinavir
- Nembutal Sodium
- nevirapine
- Norvir
- Norvir Soft Gelatin
- Onfi
- oxcarbazepine
- Oxtellar Xr
- Peganone
- pentobarbital sodium
- perampanel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- phentermine-topiramate
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prezista
- Priftin
- primidone
- Provigil
- Qsymia
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- rufinamide
- saquinavir mesylate
- secobarbital sodium
- Seconal Sodium
- St. John's wort
- Stribild
- Sustiva
- Tafinlar
- Tegretol
- Tegretol Xr
- telaprevir
- Tencon
- tipranavir
- tizanidine
- Topamax
- Topiragen
- topiramate
- Tracleer
- Trileptal
- Trokendi Xr
- Victrelis
- Viracept
- Viramune
- Viramune Xr
- vit C-St. John wort-elder-hb30
- Women's Complex
- Zanaflex
- Zebutal
Severe
Moderate
- A-hydrocort
- A-methapred
- Adoxa
- aminophylline
- amoxicil-clarithromy-lansopraz
- amoxicillin
- amoxicillin-pot clavulanate
- ampicillin
- ampicillin sodium
- ampicillin-sulbactam
- Anucort-hc
- Anusol-hc
- aprepitant
- Aristospan Intra-articular
- Aristospan Intralesional
- Augmentin
- Augmentin Es-600
- Augmentin Xr
- Avidoxy
- betamethasone acet & sod phos
- Bicillin C-r
- Bicillin L-a
- Bivigam
- budesonide
- Carimune Nf Nanofiltered
- ceftazidime
- ceftazidime in D5W
- ceftazidime-dextrose (iso-osm)
- Ceftin
- cefuroxime axetil
- cefuroxime in sterile water
- cefuroxime sodium
- cefuroxime-dextrose (iso-osm)
- Celestone Soluspan
- colesevelam
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- demeclocycline
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dicloxacillin
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- Elixophyllin
- Emend
- Entocort Ec
- Evista
- Ez Use Joint-tunnel-trigger
- First-duke's
- First-mary's Mouthwash
- Flebogamma Dif
- Flo-pred
- fludrocortisone
- Fortaz
- Fortaz In Dextrose 5 %
- fosaprepitant
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- Hizentra
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Juxtapid
- Kenalog
- Lamictal
- Lamictal Odt
- Lamictal Odt Starter (blue)
- Lamictal Odt Starter (green)
- Lamictal Odt Starter (orange)
- Lamictal Starter (blue) Kit
- Lamictal Starter (green) Kit
- Lamictal Starter (orange) Kit
- Lamictal Xr
- Lamictal Xr Starter (blue)
- Lamictal Xr Starter (green)
- Lamictal Xr Starter (orange)
- lamotrigine
- lomitapide
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- Minocin
- minocycline
- Monodox
- Morgidox
- nafcillin
- nafcillin in dextrose iso-osm
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Oracea
- Orapred
- Orapred Odt
- oxacillin
- oxacillin in dextrose(iso-osm)
- Pediapred
- penicillin G benzathine
- penicillin G benzathine & proc
- penicillin G pot in dextrose
- penicillin G potassium
- penicillin G procaine
- penicillin G sodium
- penicillin V potassium
- Pfizerpen-g
- Physicians Ez Use M-pred
- piperacillin-tazobactam
- piperacillin-tazobactam-dextrs
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prevpac
- Privigen
- Proctocort
- raloxifene
- Rayos
- Rectacort-hc
- Solodyn
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Tazicef
- tetracycline
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- ticarcillin-clavulanate
- tigecycline
- Timentin
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Tygacil
- Uceris
- Unasyn
- Veripred 20
- Vibramycin
- Welchol
- Zinacef
- Zinacef In Sterile Water
- Zosyn
- Zosyn In Dextrose (iso-osm)
- Acute myocardial infarction
- Antithrombin III deficiency
- Carcinoma of breast
- Cerebrovascular accident
- Deep venous thrombosis
- Disease of liver
- Estrogen-dependent neoplasm
- Migraine with aura
- Predisposition to thrombosis
- Protein C deficiency disease
- Pulmonary thromboembolism
- Thromboembolic disorder
- Thrombophilia
- Thrombophlebitis
- Tobacco smoker
Contraindicated
- Coronary artery disease
- Diabetes mellitus
- Family history of malignant tumor of breast
- Hereditary angioedema
- Hypercholesterolemia
- Hypertension
- Increased cardiovascular event risk
- Invasive surgical procedure
- Migraine with aura
- Papilledema
- Retinal thrombosis
- Valvular heart disease
Severe
Moderate
- Depression
- Gallbladder disease
- Hypertriglyceridemia
- Hypoparathyroidism
- Hypothyroidism
ETHYNODIOL-ETHINYL ESTRADIOL (ETHYNODIOL DIACETATE-ETHINYL ESTRADIOL)
- Pregnancy contraception
- None
- Abdominal distension
- Acne vulgaris
- Body fluid retention
- Dizziness
- Mastalgia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Deep venous thrombosis
- Hyperlipidemia
- Hypertension
- Abdominal pain with cramps
- Abnormal glucose tolerance
- Acute abdominal pain
- Chloasma
- Gynecomastia
- Headache disorder
- Libido changes
- Menorrhagia
- Migraine
- Skin photosensitivity
- Vulvovaginal candidiasis
- Weight gain
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute occlusion of mesenteric vein
- Anaphylaxis
- Angioedema
- Arterial thrombosis
- Benign hepatic cell adenoma
- Biliary calculus
- Cataracts
- Cerebrovascular accident
- Colitis
- Dysplasia of cervix
- Dyspnea
- Focal nodular hyperplasia of liver
- Gallbladder disease
- General weakness
- Hemolytic uremic syndrome
- Hemorrhagic stroke
- Hepatic vein thrombosis
- Hepatitis
- Hypersensitivity drug reaction
- Hypertriglyceridemia
- Kidney disease with reduction in GFR
- Liver cell carcinoma
- Neoplasm of breast
- Neoplasm of liver
- Obstructive hyperbilirubinemia
- Optic neuritis
- Pancreatitis
- Pulmonary thromboembolism
- Retinal thrombosis
- Thromboembolic disorder
- Thrombotic disorder
- Unconsciousness
Less Severe
- Abnormal vaginal bleeding
- Alopecia
- Amenorrhea
- Appetite changes
- Back pain
- Cervical discharge
- Change in corneal curvature
- Depression
- Diarrhea
- Dysmenorrhea
- Edema
- Erosion of cervix
- Erythema multiforme
- Erythema nodosum
- Fatigue
- Folate deficiency
- Galactorrhea not associated with childbirth
- Hirsutism
- Insomnia
- Irregular menstrual periods
- Mood changes
- Muscle spasm
- Nervousness
- Oligomenorrhea
- Pelvic pain
- Peripheral edema
- Premenstrual syndrome
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Urticaria
- Vaginal dryness
- Vaginitis
Contraindicated
None
Severe Precaution
Oral Contraceptives
Not indicated before menarche.
- 1 Day – 13 Years
- Not indicated before menarche.
Management or Monitoring Precaution
None
Combination Oral Contraceptives
- Severity Level:
2
- Additional Notes: Avail data no known risk for developmental toxicity after inadvertent exposure
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ethynodiol Diacetate-ethinyl Estradiol
May decrease quantity and quality of breastmilk; may affect infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease quantity and quality of breastmilk; may affect infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Estrogenic Agents (systemic)
General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Cardiovascular-May increase risk for thromboembolic events. Avoid use in patients with known, suspected, or history of arterial or venous thromboembolic disease. Neuro/Psych-May increase the risk for dementia. Genitourinary-May aggravate urinary incontinence.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Do not use this medication if you smoke cigarettes/use tobacco and are over 35 years old. Smoking raises your risk of stroke, heart attack, blood clots, and high blood pressure from hormonal birth control (such as the pill, patch, ring). The risk of these serious problems increases with age and with the number of cigarettes you smoke. Do not smoke or use tobacco.
| Pregnancy contraception | |
| Z30 | Encounter for contraceptive management |
| Z30.01 | Encounter for initial prescription of contraceptives |
| Z30.011 | Encounter for initial prescription of contraceptive pills |
| Z30.013 | Encounter for initial prescription of injectable contraceptive |
| Z30.014 | Encounter for initial prescription of intrauterine contraceptive device |
| Z30.015 | Encounter for initial prescription of vaginal ring hormonal contraceptive |
| Z30.016 | Encounter for initial prescription of transdermal patch hormonal contraceptive device |
| Z30.017 | Encounter for initial prescription of implantable subdermal contraceptive |
| Z30.018 | Encounter for initial prescription of other contraceptives |
| Z30.019 | Encounter for initial prescription of contraceptives, unspecified |
| Z30.4 | Encounter for surveillance of contraceptives |
| Z30.40 | Encounter for surveillance of contraceptives, unspecified |
| Z30.41 | Encounter for surveillance of contraceptive pills |
| Z30.42 | Encounter for surveillance of injectable contraceptive |
| Z30.43 | Encounter for surveillance of intrauterine contraceptive device |
| Z30.430 | Encounter for insertion of intrauterine contraceptive device |
| Z30.431 | Encounter for routine checking of intrauterine contraceptive device |
| Z30.433 | Encounter for removal and reinsertion of intrauterine contraceptive device |
| Z30.44 | Encounter for surveillance of vaginal ring hormonal contraceptive device |
| Z30.45 | Encounter for surveillance of transdermal patch hormonal contraceptive device |
| Z30.46 | Encounter for surveillance of implantable subdermal contraceptive |
| Z30.49 | Encounter for surveillance of other contraceptives |
| Z30.8 | Encounter for other contraceptive management |
| Z30.9 | Encounter for contraceptive management, unspecified |
| Z79.3 | Long term (current) use of hormonal contraceptives |
| Z97.5 | Presence of (intrauterine) contraceptive device |
| 0-9 | A-Z |
|---|---|
| Z30 | Encounter for contraceptive management |
| Z30.01 | Encounter for initial prescription of contraceptives |
| Z30.011 | Encounter for initial prescription of contraceptive pills |
| Z30.013 | Encounter for initial prescription of injectable contraceptive |
| Z30.014 | Encounter for initial prescription of intrauterine contraceptive device |
| Z30.015 | Encounter for initial prescription of vaginal ring hormonal contraceptive |
| Z30.016 | Encounter for initial prescription of transdermal patch hormonal contraceptive device |
| Z30.017 | Encounter for initial prescription of implantable subdermal contraceptive |
| Z30.018 | Encounter for initial prescription of other contraceptives |
| Z30.019 | Encounter for initial prescription of contraceptives, unspecified |
| Z30.4 | Encounter for surveillance of contraceptives |
| Z30.40 | Encounter for surveillance of contraceptives, unspecified |
| Z30.41 | Encounter for surveillance of contraceptive pills |
| Z30.42 | Encounter for surveillance of injectable contraceptive |
| Z30.43 | Encounter for surveillance of intrauterine contraceptive device |
| Z30.430 | Encounter for insertion of intrauterine contraceptive device |
| Z30.431 | Encounter for routine checking of intrauterine contraceptive device |
| Z30.433 | Encounter for removal and reinsertion of intrauterine contraceptive device |
| Z30.44 | Encounter for surveillance of vaginal ring hormonal contraceptive device |
| Z30.45 | Encounter for surveillance of transdermal patch hormonal contraceptive device |
| Z30.46 | Encounter for surveillance of implantable subdermal contraceptive |
| Z30.49 | Encounter for surveillance of other contraceptives |
| Z30.8 | Encounter for other contraceptive management |
| Z30.9 | Encounter for contraceptive management, unspecified |
| Z79.3 | Long term (current) use of hormonal contraceptives |
| Z97.5 | Presence of (intrauterine) contraceptive device |
Formulary Reference Tool