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CLORAZEPATE DIPOTASSIUM (CLORAZEPATE DIPOTASSIUM)
- Alcohol withdrawal syndrome
- Anxiety
- Partial epilepsy treatment adjunct
7.5 mg tablet
- 1 tablet (7.5 mg) by oral route 2 times per day
15 mg tablet
- 1 tablet (15 mg) by oral route 2 times per day
3.75 mg tablet
- 1 tablet (3.75 mg) by oral route 2 times per day
7.5 mg tablet
- 1 tablet (7.5 mg) by oral route 2 times per day
Alcohol withdrawal syndrome
- 1 tablet (3.75 mg) by oral route 2 times per day
- 1 tablet (3.75 mg) by oral route 4 times per day
Anxiety
- 2 tablets (15 mg) by oral route 2 times per day
- 2 tablets (15 mg) by oral route 4 times per day
- 1 tablet (15 mg) by oral route 4 times per day
- 1 tablet (15 mg) by oral route 2 times per day
- 2 tablets (7.5 mg) by oral route 2 times per day
- 2 tablets (7.5 mg) by oral route 4 times per day
- 1 tablet (7.5 mg) by oral route 2 times per day
- 1 tablet (7.5 mg) by oral route 4 times per day
Partial epilepsy treatment adjunct
- 1 tablet (15 mg) by oral route 3 times per day
- 2 tablets (15 mg) by oral route 3 times per day
- 2 tablets (30 mg) by oral route 3 times per day
- 2 tablets (7.5 mg) by oral route 3 times per day
- 1 tablet (7.5 mg) by oral route 3 times per day
- sodium oxybate
- Xyrem
Contraindicated
- clozapine
- Clozaril
- Dehydrated Alcohol
- ethanol (ethyl alcohol)
- ethyl alcohol-herbal drugs
- Fazaclo
- fluoxetine
- fluvoxamine
- Luvox Cr
- Lydia Pinkham Herbal
- nefazodone
- olanzapine-fluoxetine
- Prozac
- Prozac Weekly
- Sarafem
- Symbyax
- Versacloz
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- buprenorphine-naloxone
- cimetidine
- Heartburn Relief
- Suboxone
- Tagamet Hb
- Zubsolv
- Angle-closure glaucoma
- Pregnancy
Contraindicated
- Alcohol intoxication
- Depression
- Drug abuse
- Psychotic disorder
- Respiratory depression
- Severe chronic obstructive pulmonary disease
- Suicidal ideation
Severe
Moderate
- Anemia
- Disease of liver
- Hypoalbuminemia
- Kidney disease with likely reduction in GFR
- Sleep apnea
CLORAZEPATE DIPOTASSIUM (CLORAZEPATE DIPOTASSIUM)
- Alcohol withdrawal syndrome
- Anxiety
- Partial epilepsy treatment adjunct
- Muscle weakness
- Ataxia
- Dizziness
- Drowsy
- Dyspepsia
- Slurred speech
More Frequent
Severe
Less Severe
- Acute confusion
- Behavioral disorders
- CNS depression
- Diarrhea
- Fatigue
- General weakness
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Accidental fall
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Apnea
- Coma
- Dehydration
- Depression
- Disease of liver
- Drug-induced psychosis
- Eosinophilia
- Hallucinations
- Hemolytic anemia
- Hepatomegaly
- Hostility
- Hypotension
- Jaundice
- Leukocytosis
- Leukopenia
- Manic disorder
- Memory impairment
- Neutropenic disorder
- Respiratory depression
- Seizure disorder
- Skin rash
- Sleep walking disorder
- Suicidal ideation
- Thrombocytopenic disorder
- Urinary retention
Less Severe
- Aggressive behavior
- Agitation
- Alopecia
- Anorexia
- Aphonia
- Blurred vision
- Bronchial congestion
- Complex sleep behavior
- Concentration difficulty
- Conjunctivitis
- Constipation
- Contact dermatitis
- Cramps
- Delirium
- Depersonalization
- Diplopia
- Disturbance in thinking
- Dream disorder
- Drug dependence
- Dry eye
- Dry skin
- Dysarthria
- Dyspnea
- Dysuria
- Excitement
- Eyes vertical deviation
- Facial edema
- Gastritis
- Gingival pain
- Glossitis
- Headache disorder
- Hiccups
- Hirsutism
- Increased appetite
- Irritability
- Libido changes
- Loss of taste
- Lymphadenopathy
- Menstrual disorder
- Myalgias
- Nausea
- Nervousness
- Nightmares
- Nocturia
- Nystagmus
- Orthostatic hypotension
- Palpitations
- Paranoid disorder
- Polydipsia
- Pruritus of skin
- Rhinorrhea
- Sialorrhea
- Sleep disorder
- Sneezing
- Sore tongue
- Stomatitis
- Swelling of ankles or feet
- Syncope
- Tachycardia
- Tremor
- Urinary incontinence
- Urine discoloration
- Vertigo
- Visual changes
- Visual field defect
- Vomiting
- Weight gain
- Weight loss
- Xerostomia
- Yawning
Contraindicated
None
Severe Precaution
Clorazepate
Not recommended age < 9 years due to insufficient clinical experience.
- 1 Day – 9 Years
- Not recommended age < 9 years due to insufficient clinical experience.
Management or Monitoring Precaution
None
Clorazepate Dipotassium
- Severity Level:
1
- Additional Notes: One report of multiple anomalies;other benzodiazep assoc w/congen malformations
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Clorazepate
Not rec by mfr, poss excret; may cause feeding difficulty, drowsiness,wt loss
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Not rec by mfr, poss excret; may cause feeding difficulty, drowsiness,wt loss |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Clorazepate
Neuro/Psych-Increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes. Long half-life benzodiazepines are generally not preferred in the elderly. If used, limit dose to 15mg/day. General-May be appropriate for select indications including seizure disorder and alcohol withdrawal.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Taking clorazepate with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of clorazepate that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.
| Alcohol withdrawal syndrome | |
| F10.23 | Alcohol dependence with withdrawal |
| F10.230 | Alcohol dependence with withdrawal, uncomplicated |
| F10.231 | Alcohol dependence with withdrawal delirium |
| F10.232 | Alcohol dependence with withdrawal with perceptual disturbance |
| F10.239 | Alcohol dependence with withdrawal, unspecified |
| Anxiety | |
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
| Partial epilepsy treatment adjunct | |
| G40.0 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset |
| G40.00 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable |
| G40.009 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, without status epilepticus |
| G40.01 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable |
| G40.019 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, without status epilepticus |
| G40.1 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures |
| G40.10 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable |
| G40.109 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, without status epilepticus |
| G40.11 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable |
| G40.119 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, without status epilepticus |
| G40.2 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures |
| G40.20 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable |
| G40.209 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, without status epilepticus |
| G40.21 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable |
| G40.219 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, without status epilepticus |
| 0-9 | A-Z |
|---|---|
| F06.4 | Anxiety disorder due to known physiological condition |
| F10.180 | Alcohol abuse with alcohol-induced anxiety disorder |
| F10.23 | Alcohol dependence with withdrawal |
| F10.230 | Alcohol dependence with withdrawal, uncomplicated |
| F10.231 | Alcohol dependence with withdrawal delirium |
| F10.232 | Alcohol dependence with withdrawal with perceptual disturbance |
| F10.239 | Alcohol dependence with withdrawal, unspecified |
| F10.280 | Alcohol dependence with alcohol-induced anxiety disorder |
| F10.980 | Alcohol use, unspecified with alcohol-induced anxiety disorder |
| F12.180 | Cannabis abuse with cannabis-induced anxiety disorder |
| F12.280 | Cannabis dependence with cannabis-induced anxiety disorder |
| F12.980 | Cannabis use, unspecified with anxiety disorder |
| F14.180 | Cocaine abuse with cocaine-induced anxiety disorder |
| F14.280 | Cocaine dependence with cocaine-induced anxiety disorder |
| F14.980 | Cocaine use, unspecified with cocaine-induced anxiety disorder |
| F15.180 | Other stimulant abuse with stimulant-induced anxiety disorder |
| F15.280 | Other stimulant dependence with stimulant-induced anxiety disorder |
| F15.980 | Other stimulant use, unspecified with stimulant-induced anxiety disorder |
| F16.180 | Hallucinogen abuse with hallucinogen-induced anxiety disorder |
| F16.280 | Hallucinogen dependence with hallucinogen-induced anxiety disorder |
| F16.980 | Hallucinogen use, unspecified with hallucinogen-induced anxiety disorder |
| F18.180 | Inhalant abuse with inhalant-induced anxiety disorder |
| F18.280 | Inhalant dependence with inhalant-induced anxiety disorder |
| F18.980 | Inhalant use, unspecified with inhalant-induced anxiety disorder |
| F19.180 | Other psychoactive substance abuse with psychoactive substance-induced anxiety disorder |
| F19.280 | Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder |
| F19.980 | Other psychoactive substance use, unspecified with psychoactive substance-induced anxiety disorder |
| F40 | Phobic anxiety disorders |
| F40.0 | Agoraphobia |
| F40.00 | Agoraphobia, unspecified |
| F40.01 | Agoraphobia with panic disorder |
| F40.02 | Agoraphobia without panic disorder |
| F40.1 | Social phobias |
| F40.10 | Social phobia, unspecified |
| F40.11 | Social phobia, generalized |
| F40.8 | Other phobic anxiety disorders |
| F40.9 | Phobic anxiety disorder, unspecified |
| F41 | Other anxiety disorders |
| F41.0 | Panic disorder [episodic paroxysmal anxiety] |
| F41.1 | Generalized anxiety disorder |
| F41.3 | Other mixed anxiety disorders |
| F41.8 | Other specified anxiety disorders |
| F41.9 | Anxiety disorder, unspecified |
| F93.0 | Separation anxiety disorder of childhood |
| G40.0 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset |
| G40.00 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable |
| G40.009 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, without status epilepticus |
| G40.01 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable |
| G40.019 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, without status epilepticus |
| G40.1 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures |
| G40.10 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable |
| G40.109 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, without status epilepticus |
| G40.11 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable |
| G40.119 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, without status epilepticus |
| G40.2 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures |
| G40.20 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable |
| G40.209 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, without status epilepticus |
| G40.21 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable |
| G40.219 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, without status epilepticus |
Formulary Reference Tool