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CHLORTHALIDONE (CHLORTHALIDONE)
- Edema
- Hypertension
- Peripheral edema due to chronic heart failure
- Pulmonary edema due to chronic heart failure
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
50 mg tablet
- 1 tablet (50 mg) by oral route once daily
Edema
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route every other day
- 2 tablets (100 mg) by oral route 3 times per week
Hypertension
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
Peripheral edema due to chronic heart failure
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route every other day
- 2 tablets (100 mg) by oral route 3 times per week
Pulmonary edema due to chronic heart failure
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route every other day
- 2 tablets (100 mg) by oral route 3 times per week
- dofetilide
- Tikosyn
Contraindicated
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- lithium carbonate
- lithium citrate
- Lithobid
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Amaryl
- Apidra
- Apidra Solostar
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Colestid
- Colestid Flavored
- colestipol
- Diabeta
- diazoxide
- Digox
- digoxin
- Duetact
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Levemir
- Levemir Flexpen
- miglitol
- nateglinide
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- pioglitazone-glimepiride
- Precose
- Prevalite
- Proglycem
- Questran
- Questran Light
- Starlix
- tolazamide
- tolbutamide
- Anuria
- Lactating mother
Contraindicated
- Kidney disease with reduction in GFR
- Oliguria
- Pregnancy
Severe
Moderate
- Gout
- Hypercalcemia
- Hypercholesterolemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Sympathectomy
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
CHLORTHALIDONE (CHLORTHALIDONE)
- Edema
- Hypertension
- Peripheral edema due to chronic heart failure
- Pulmonary edema due to chronic heart failure
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- None
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Diarrhea
- Dizziness
- Fatigue
- Nausea
- Orthostatic hypotension
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Aplastic anemia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Purpura
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Erectile dysfunction
- Fever
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Muscle spasm
- Nervousness
- Paresthesia
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Chlorthalidone
No safety and efficacy data in children.
- 1 Day – 364 Days
- No safety and efficacy data in children.
Chlorthalidone
- Severity Level:
D
- Additional Notes: Avoid as first line treatment for hypertension during pregnancy
Contraindicated
Chlorthalidone
Mfg does not rec, minimal amnts may be excreted; may suppress lactation
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Mfg does not rec, minimal amnts may be excreted; may suppress lactation |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Chlorthalidone
General-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Cardiovascular-Elderly are more sensitive to blood pressure changes. Renal-Less effective in severe renal impairment. Endocrine-May exacerbate SIADH.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Edema | |
| R60 | Edema, not elsewhere classified |
| R60.0 | Localized edema |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Peripheral edema due to chronic heart failure | |
| R60 | Edema, not elsewhere classified |
| R60.9 | Edema, unspecified |
| Pulmonary edema due to chronic heart failure | |
| J81.0 | Acute pulmonary edema |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| J81.0 | Acute pulmonary edema |
| R60 | Edema, not elsewhere classified |
| R60 | Edema, not elsewhere classified |
| R60.0 | Localized edema |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| R60.9 | Edema, unspecified |
Formulary Reference Tool