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BUPROPION HCL (BUPROPION HCL)
- Major depressive disorder
100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
75 mg tablet
- 1 tablet (75 mg) by oral route 3 times per day
Major depressive disorder
- 1 tablet (75 mg) by oral route 3 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 4 times per day
- 2 tablets (150 mg) by oral route 3 times per day
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- atomoxetine
- Brintellix
- Datscan
- ioflupane I 123
- isoniazid-rifamp-pyrazinamide
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Soltamox
- Strattera
- tamoxifen
- vortioxetine
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- acarbose
- acetaminophen-codeine
- Actoplus Met
- Actoplus Met Xr
- Actos
- Adasuve
- alogliptin-metformin
- alogliptin-pioglitazone
- Amaryl
- aminophylline
- amitriptyline
- amitriptyline-chlordiazepoxide
- amoxapine
- Anafranil
- Anucort-hc
- Anusol-hc
- Apidra
- Apidra Solostar
- aripiprazole
- Aristospan Intra-articular
- Aristospan Intralesional
- Ascomp With Codeine
- betamethasone acet & sod phos
- Brisdelle
- bromphen-pseudoephed-codeine
- brompheniramine-PE-codeine
- budesonide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- Capcof
- Capital With Codeine
- carisoprodol-ASA-codeine
- Celestone Soluspan
- Celexa
- Cheratussin Ac
- Cheratussin Dac
- chlorcyclizine-codeine
- chlorphen-pseudoephed-codeine
- chlorpheniramine-codeine
- chlorpheniramine-PE-codeine
- chlorpromazine
- citalopram
- clomipramine
- clozapine
- Clozaril
- clrcycliz-pseudoephed-codeine
- codeine sulfate
- codeine-butalbital-ASA-caff
- codeine-guaifenesin
- codeine-pyrilamine
- Colocort
- Compazine
- Compro
- Conzip
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Cymbalta
- Depo-medrol
- desipramine
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- dexbrompheniramine-PSE-codeine
- dexchlorphen-phenyleph-codeine
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diabeta
- doxepin
- droperidol
- Duetact
- duloxetine
- Effexor Xr
- Elixophyllin
- Entocort Ec
- escitalopram oxalate
- Ez Use Joint-tunnel-trigger
- Fazaclo
- Fetzima
- Fioricet With Codeine
- Fiorinal-codeine #3
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- fluoxetine
- fluphenazine decanoate
- fluphenazine HCl
- fluvoxamine
- Fortamet
- Geodon
- glimepiride
- glipizide
- glipizide-metformin
- Glucophage
- Glucophage Xr
- Glucotrol
- Glucotrol Xl
- Glucovance
- Glumetza
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Grx Hicort 25
- Guaiatussin Ac
- Guaifenesin Ac
- Guaifenesin Dac
- Guiatuss Ac
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- imipramine HCl
- imipramine pamoate
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Invega
- Invega Sustenna
- Iophen C-nr
- Janumet
- Janumet Xr
- Jentadueto
- Kaletra
- Kazano
- Kenalog
- Khedezla
- Kombiglyze Xr
- Lantus
- Lantus Solostar
- Latuda
- Levemir
- Levemir Flexpen
- levomilnacipran
- Lexapro
- linagliptin-metformin
- lopinavir-ritonavir
- Lortuss Ex
- loxapine
- loxapine succinate
- Loxitane
- lurasidone
- Luvox Cr
- M-clear Wc
- M-end Max D
- M-end Pe
- maprotiline
- Mar-cof Bp
- Mar-cof Cg
- Medrol
- Medrol (pak)
- metformin
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- miglitol
- Millipred
- Millipred Dp
- milnacipran
- mirtazapine
- nateglinide
- nefazodone
- Norpramin
- nortriptyline
- Norvir
- Norvir Soft Gelatin
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- olanzapine
- olanzapine pamoate
- olanzapine-fluoxetine
- Oleptro Er
- Orapred
- Orapred Odt
- Oseni
- paliperidone
- paliperidone palmitate
- Pamelor
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pediapred
- perphenazine
- perphenazine-amitriptyline
- Pexeva
- Phenadoz
- Phenergan
- Phenylhistine
- Phenylhistine Dh
- Physicians Ez Use M-pred
- pioglitazone
- pioglitazone-glimepiride
- pioglitazone-metformin
- Poly-tussin
- Poly-tussin Ac
- Poly-tussin D
- Prandimet
- Prandin
- Precose
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Pristiq
- Pro-clear Ac
- Pro-clear Caps
- Pro-red Ac (w/ Dexchlorphenir)
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- Proctocort
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- protriptyline
- Prozac
- Prozac Weekly
- pseudoephedrine-codeine-GG
- quetiapine
- Rayos
- Rectacort-hc
- Relcof C
- Remeron
- Remeron Soltab
- repaglinide
- repaglinide-metformin
- Riomet
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- ritonavir
- Rydex
- Sarafem
- Savella
- saxagliptin-metformin
- Seroquel
- Seroquel Xr
- sertraline
- Silenor
- sitagliptin-metformin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Starlix
- Statuss Green (codeine)
- Surmontil
- Symbyax
- Synapryn
- tetrabenazine
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- thioridazine
- thiothixene
- Tofranil
- Tofranil-pm
- tolazamide
- tolbutamide
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- trazodone
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- trifluoperazine
- trimipramine
- Trymine Cg
- Tusnel C
- Tylenol-codeine #3
- Tylenol-codeine #4
- Uceris
- Ultracet
- Ultram
- Ultram Er
- venlafaxine
- Veripred 20
- Versacloz
- Viibryd
- vilazodone
- Virtussin Ac
- Vivactil
- Xenazine
- Z-tuss Ac
- Z-tuss E
- ziprasidone HCl
- ziprasidone mesylate
- Zodryl Ac 25
- Zodryl Ac 30
- Zodryl Ac 35
- Zodryl Ac 40
- Zodryl Ac 50
- Zodryl Ac 60
- Zodryl Ac 80
- Zodryl Dac 25
- Zodryl Dac 30
- Zodryl Dac 35
- Zodryl Dac 40
- Zodryl Dac 50
- Zodryl Dac 60
- Zodryl Dac 80
- Zodryl Dec 25
- Zodryl Dec 30
- Zodryl Dec 35
- Zodryl Dec 40
- Zodryl Dec 50
- Zodryl Dec 60
- Zodryl Dec 80
- Zoloft
- Zyprexa
- Zyprexa Relprevv
- Zyprexa Zydis
- Alcohol withdrawal syndrome
- Anorexia nervosa
- Bulimia nervosa
- Lower seizure threshold
- Seizure disorder
- Seizure due to abrupt benzodiazepine withdrawal
Contraindicated
- Alcoholism
- Angle-closure glaucoma
- Central nervous system neoplasm
- Cerebral metastases
- Hostility
- Opioid dependence
- Risk of angle-closure glaucoma due to narrow angle
- Sedative drug dependence
- Severe hepatic disease
- Stimulant drug dependence
- Suicidal ideation
Severe
Moderate
- Acute myocardial infarction
- Bipolar disorder
- Hypertension
- Hypomania
- Psychotic disorder
- Weight loss
BUPROPION HCL (BUPROPION HCL)
- Major depressive disorder
- Agitation
- Acute abdominal pain
- Anorexia
- Arthralgias
- Concentration difficulty
- Constipation
- Diarrhea
- Dizziness
- Dream disorder
- Headache disorder
- Hyperhidrosis
- Insomnia
- Nausea
- Nervousness
- Palpitations
- Pharyngitis
- Rhinitis
- Symptoms of anxiety
- Tinnitus
- Tremor
- Weight loss
- Xerostomia
More Frequent
Severe
Less Severe
- Cardiac arrhythmia
- Hypertension
- Hypotension
- Infection
- Urticaria
- Acute confusion
- Ataxia
- Blurred vision
- Bronchitis
- Chest pain
- Cough
- Drowsy
- Drug-induced hot flash
- Dry skin
- Dyspepsia
- Dysphagia
- Epistaxis
- Fever
- Flatulence
- Flushing
- General weakness
- Hearing disorder
- Increased appetite
- Increased urinary frequency
- Irritability
- Libido changes
- Menstrual disorder
- Migraine
- Myalgias
- Myoclonus
- Neck pain
- Pruritus of skin
- Skin rash
- Stomatitis
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Accommodation disorder
- Acquired dystonia
- Acute myocardial infarction
- Akathisia
- Anaphylaxis
- Angioedema
- Atrioventricular block
- Bronchospastic pulmonary disease
- Colitis
- Coma
- Complete atrioventricular block
- Delusional disorder
- Drug-induced psychosis
- Dyskinesia
- Erythema multiforme
- Esophagitis
- Extrasystoles
- Gastric ulcer
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Hallucinations
- Hearing loss
- Hepatitis
- Homicidal ideation
- Hypersensitivity drug reaction
- Leukocytosis
- Leukopenia
- Manic disorder
- Ocular hypertension
- Orthostatic hypotension
- Pancreatitis
- Pancytopenia
- Paranoid disorder
- Parkinsonism
- Pulmonary thromboembolism
- Rhabdomyolysis
- Secondary angle-closure glaucoma
- Seizure disorder
- SIADH syndrome
- Stevens-johnson syndrome
- Suicidal
- Suicidal ideation
- Tardive dyskinesia
- Thrombocytopenic disorder
- Unconsciousness
Less Severe
- Abnormal electroencephalogram
- Abnormal vaginal bleeding
- Aggressive behavior
- Anemia
- Aphasia
- Behavioral disorders
- Cramps in legs
- Cystitis
- Delirium
- Disorder of ejaculation
- Dry eye
- Dysarthria
- Dysgeusia
- Dyspareunia
- Dyspnea
- Dysuria
- Ecchymosis
- Erectile dysfunction
- Euphoria
- Exfoliative dermatitis
- Facial edema
- Gingival bleeding
- Glycosuria
- Gynecomastia
- Hirsutism
- Hostility
- Hyperglycemia
- Hypoglycemic disorder
- Hypomania
- Hyponatremia
- Increased libido
- Lymphadenopathy
- Malaise
- Muscle rigidity
- Muscle weakness
- Mydriasis
- Nocturia
- Panic disorder
- Paresthesia
- Phlebitis
- Pneumonia
- Polyuria
- Salpingitis
- Sialorrhea
- Skin photosensitivity
- Syncope
- Tachycardia
- Urinary incontinence
- Urinary retention
- Vaginitis
Contraindicated
None
Severe Precaution
Bupropion
Possible increased suicidal ideation and attempt with underlying major depression. No safety and efficacy established.
- 1 Day – 18 Years
- Possible increased suicidal ideation and attempt with underlying major depression. No safety and efficacy established.
Management or Monitoring Precaution
None
Bupropion
- Severity Level:
2
- Additional Notes: Available human data suggest developmental toxicity risk is low.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Bupropion
Insufficient human data; low levels excreted in breast milk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data; low levels excreted in breast milk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Bupropion
Hepatic-Lower doses are generally recommended in elderly. Bupropion is extensively metabolized to active metabolites, and the elderly may accumulate drug. Renal-Possible accumulation of active metabolites. Consider lower dose for GFR<90 mL/min and monitoring renal function. Neuro/Psych-Consider bupropion CNS side effects of dizziness, insomnia, somnolence and memory loss when using in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mental/mood disorders, and smoking cessation. Antidepressants can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience new or worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication, even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice new or worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.<br /><br /> If you are using bupropion to quit smoking, stop taking bupropion and contact your doctor right away if you experience any of the symptoms listed above. Tell your doctor right away if you have any of these symptoms after stopping treatment.
| Major depressive disorder | |
| F32 | Major depressive disorder, single episode |
| F32.0 | Major depressive disorder, single episode, mild |
| F32.1 | Major depressive disorder, single episode, moderate |
| F32.2 | Major depressive disorder, single episode, severe without psychotic features |
| F32.3 | Major depressive disorder, single episode, severe with psychotic features |
| F32.4 | Major depressive disorder, single episode, in partial remission |
| F32.5 | Major depressive disorder, single episode, in full remission |
| F32.9 | Major depressive disorder, single episode, unspecified |
| F33 | Major depressive disorder, recurrent |
| F33.0 | Major depressive disorder, recurrent, mild |
| F33.1 | Major depressive disorder, recurrent, moderate |
| F33.2 | Major depressive disorder, recurrent severe without psychotic features |
| F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
| F33.4 | Major depressive disorder, recurrent, in remission |
| F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
| F33.41 | Major depressive disorder, recurrent, in partial remission |
| F33.42 | Major depressive disorder, recurrent, in full remission |
| F33.9 | Major depressive disorder, recurrent, unspecified |
| 0-9 | A-Z |
|---|---|
| F32 | Major depressive disorder, single episode |
| F32.0 | Major depressive disorder, single episode, mild |
| F32.1 | Major depressive disorder, single episode, moderate |
| F32.2 | Major depressive disorder, single episode, severe without psychotic features |
| F32.3 | Major depressive disorder, single episode, severe with psychotic features |
| F32.4 | Major depressive disorder, single episode, in partial remission |
| F32.5 | Major depressive disorder, single episode, in full remission |
| F32.9 | Major depressive disorder, single episode, unspecified |
| F33 | Major depressive disorder, recurrent |
| F33.0 | Major depressive disorder, recurrent, mild |
| F33.1 | Major depressive disorder, recurrent, moderate |
| F33.2 | Major depressive disorder, recurrent severe without psychotic features |
| F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
| F33.4 | Major depressive disorder, recurrent, in remission |
| F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
| F33.41 | Major depressive disorder, recurrent, in partial remission |
| F33.42 | Major depressive disorder, recurrent, in full remission |
| F33.9 | Major depressive disorder, recurrent, unspecified |
Formulary Reference Tool