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DURACLON (CLONIDINE HCL/PF)
- Severe pain
- Duraclon (pf) Epidural Solution
- Duraclon (pf) Epidural
- Clonidine (pf) Epidural Solution
- By Indication
(PF) 1,000 mcg/10 mL (100 mcg/mL) epidural solution
- Infuse 0.03 mg/hour by continuous epidural route
1,000 mcg/10 mL (100 mcg/mL) epidural solution
- Infuse 0.03 mg/hour by continuous epidural route
clonidine (PF) 1,000 mcg/10 mL (100 mcg/mL) epidural solution
- Infuse 0.03 mg/hour by continuous epidural route
clonidine (PF) 5,000 mcg/10 mL epidural solution
- Infuse 0.03 mg/hour by continuous epidural route
Severe pain
- Infuse 0.03 mg/hour by continuous epidural route
- Infuse 0.04 mg/hour by continuous epidural route
- None
Contraindicated
- acebutolol
- atenolol
- atenolol-chlorthalidone
- Betagan
- Betapace
- Betapace Af
- betaxolol
- Betimol
- Betoptic S
- bisoprolol fumarate
- bisoprolol-hydrochlorothiazide
- Brevibloc
- Brevibloc In Nacl (iso-osm)
- brimonidine-timolol
- Bystolic
- carteolol
- carvedilol
- carvedilol phosphate
- Combigan
- Coreg
- Coreg Cr
- Corgard
- Corzide
- Cosopt
- Cosopt Pf
- dorzolamide-timolol
- dorzolamide-timolol (PF)
- Dutoprol
- esmolol
- esmolol in NaCl (iso-osm)
- Inderal La
- Inderal Xl
- Innopran Xl
- Istalol
- labetalol
- Levatol
- levobunolol
- Lopressor
- Lopressor Hct
- metipranolol
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- nadolol
- nadolol-bendroflumethiazide
- nebivolol
- penbutolol
- pindolol
- propranolol
- propranolol-hydrochlorothiazid
- Sectral
- Sorine
- sotalol
- Sotalol Af
- Tenoretic 100
- Tenoretic 50
- Tenormin
- timolol
- timolol maleate
- timolol maleate (PF)
- Timoptic
- Timoptic Ocudose (pf)
- Timoptic-xe
- Toprol Xl
- Trandate
- Zebeta
- Ziac
Severe
Moderate
- amitriptyline
- amitriptyline-chlordiazepoxide
- amoxapine
- Amrix
- Anafranil
- clomipramine
- cyclobenzaprine
- cyclobenzaprine with msm
- desipramine
- doxepin
- imipramine HCl
- imipramine pamoate
- mirtazapine
- Norpramin
- nortriptyline
- Pamelor
- perphenazine-amitriptyline
- protriptyline
- Prudoxin
- Remeron
- Remeron Soltab
- Silenor
- Surmontil
- Tabradol
- Tofranil
- Tofranil-pm
- trimipramine
- Vivactil
- Zonalon
- Increased risk of bleeding due to coagulation disorder
Contraindicated
- Bradycardia
- Hypotension
- Perioperative care
- Respiratory depression
Severe
Moderate
- Depression
DURACLON (CLONIDINE HCL/PF)
- Severe pain
- Bradycardia
- Hypotension
- Acute confusion
- Dizziness
- Drowsy
- Nausea
- Orthostatic hypotension
- Symptoms of anxiety
- Xerostomia
More Frequent
Severe
Less Severe
- Chest pain
- Depression
- Fever
- Hallucinations
- Sedation
- Tachycardia
- Vomiting
- Anorexia
- Constipation
- Dyspnea
- Fatigue
- General weakness
- Headache disorder
- Hyperhidrosis
- Libido changes
- Skin rash
- Tinnitus
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Atrioventricular block
- Respiratory depression
Less Severe
- Dysuria
- Insomnia
- Palpitations
- Pruritus of skin
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Clonidine (Epidural)
Risk of respiratory depression. Restrict use to severe malignancy pain unresponsive to epidural or spinal opiates or other conventional analgesics.
- 1 Day – 18 Years
- Risk of respiratory depression. Restrict use to severe malignancy pain unresponsive to epidural or spinal opiates or other conventional analgesics.
Clonidine Hydrochloride
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Clonidine
Potential adverse effects to infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Potential adverse effects to infant. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Clonidine
Cardiovascular-Risk for orthostatic hypotension, falls. Caution with conduction abnormalities. Neuro/Psych-Risk of somnolence, fatigue.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Severe pain | |
| G89 | Pain, not elsewhere classified |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.12 | Acute post-thoracotomy pain |
| G89.18 | Other acute postprocedural pain |
| G89.2 | Chronic pain, not elsewhere classified |
| G89.21 | Chronic pain due to trauma |
| G89.22 | Chronic post-thoracotomy pain |
| G89.28 | Other chronic postprocedural pain |
| G89.29 | Other chronic pain |
| G89.3 | Neoplasm related pain (acute) (chronic) |
| M25.5 | Pain in joint |
| M25.50 | Pain in unspecified joint |
| M25.51 | Pain in shoulder |
| M25.511 | Pain in right shoulder |
| M25.512 | Pain in left shoulder |
| M25.519 | Pain in unspecified shoulder |
| M25.52 | Pain in elbow |
| M25.521 | Pain in right elbow |
| M25.522 | Pain in left elbow |
| M25.529 | Pain in unspecified elbow |
| M25.53 | Pain in wrist |
| M25.531 | Pain in right wrist |
| M25.532 | Pain in left wrist |
| M25.539 | Pain in unspecified wrist |
| M25.54 | Pain in joints of hand |
| M25.541 | Pain in joints of right hand |
| M25.542 | Pain in joints of left hand |
| M25.549 | Pain in joints of unspecified hand |
| M25.55 | Pain in hip |
| M25.551 | Pain in right hip |
| M25.552 | Pain in left hip |
| M25.559 | Pain in unspecified hip |
| M25.56 | Pain in knee |
| M25.561 | Pain in right knee |
| M25.562 | Pain in left knee |
| M25.569 | Pain in unspecified knee |
| M25.57 | Pain in ankle and joints of foot |
| M25.571 | Pain in right ankle and joints of right foot |
| M25.572 | Pain in left ankle and joints of left foot |
| M25.579 | Pain in unspecified ankle and joints of unspecified foot |
| M26.62 | Arthralgia of temporomandibular joint |
| M54.5 | Low back pain |
| M54.6 | Pain in thoracic spine |
| M79.6 | Pain in limb, hand, foot, fingers and toes |
| M79.60 | Pain in limb, unspecified |
| M79.601 | Pain in right arm |
| M79.602 | Pain in left arm |
| M79.603 | Pain in arm, unspecified |
| M79.604 | Pain in right leg |
| M79.605 | Pain in left leg |
| M79.606 | Pain in leg, unspecified |
| M79.609 | Pain in unspecified limb |
| M79.62 | Pain in upper arm |
| M79.621 | Pain in right upper arm |
| M79.622 | Pain in left upper arm |
| M79.629 | Pain in unspecified upper arm |
| M79.63 | Pain in forearm |
| M79.631 | Pain in right forearm |
| M79.632 | Pain in left forearm |
| M79.639 | Pain in unspecified forearm |
| M79.64 | Pain in hand and fingers |
| M79.641 | Pain in right hand |
| M79.642 | Pain in left hand |
| M79.643 | Pain in unspecified hand |
| M79.644 | Pain in right finger(s) |
| M79.645 | Pain in left finger(s) |
| M79.646 | Pain in unspecified finger(s) |
| M79.65 | Pain in thigh |
| M79.651 | Pain in right thigh |
| M79.652 | Pain in left thigh |
| M79.659 | Pain in unspecified thigh |
| M79.66 | Pain in lower leg |
| M79.661 | Pain in right lower leg |
| M79.662 | Pain in left lower leg |
| M79.669 | Pain in unspecified lower leg |
| M79.67 | Pain in foot and toes |
| M79.671 | Pain in right foot |
| M79.672 | Pain in left foot |
| M79.673 | Pain in unspecified foot |
| M79.674 | Pain in right toe(s) |
| M79.675 | Pain in left toe(s) |
| M79.676 | Pain in unspecified toe(s) |
| R07.82 | Intercostal pain |
| R10.0 | Acute abdomen |
| R10.1 | Pain localized to upper abdomen |
| R10.10 | Upper abdominal pain, unspecified |
| R10.11 | Right upper quadrant pain |
| R10.12 | Left upper quadrant pain |
| R10.2 | Pelvic and perineal pain |
| R10.3 | Pain localized to other parts of lower abdomen |
| R10.30 | Lower abdominal pain, unspecified |
| R10.31 | Right lower quadrant pain |
| R10.32 | Left lower quadrant pain |
| R10.33 | Periumbilical pain |
| R10.8 | Other abdominal pain |
| R10.84 | Generalized abdominal pain |
| R10.9 | Unspecified abdominal pain |
| R52 | Pain, unspecified |
| R68.84 | Jaw pain |
| 0-9 | A-Z |
|---|---|
| G89 | Pain, not elsewhere classified |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.12 | Acute post-thoracotomy pain |
| G89.18 | Other acute postprocedural pain |
| G89.2 | Chronic pain, not elsewhere classified |
| G89.21 | Chronic pain due to trauma |
| G89.22 | Chronic post-thoracotomy pain |
| G89.28 | Other chronic postprocedural pain |
| G89.29 | Other chronic pain |
| G89.3 | Neoplasm related pain (acute) (chronic) |
| M25.5 | Pain in joint |
| M25.50 | Pain in unspecified joint |
| M25.51 | Pain in shoulder |
| M25.511 | Pain in right shoulder |
| M25.512 | Pain in left shoulder |
| M25.519 | Pain in unspecified shoulder |
| M25.52 | Pain in elbow |
| M25.521 | Pain in right elbow |
| M25.522 | Pain in left elbow |
| M25.529 | Pain in unspecified elbow |
| M25.53 | Pain in wrist |
| M25.531 | Pain in right wrist |
| M25.532 | Pain in left wrist |
| M25.539 | Pain in unspecified wrist |
| M25.54 | Pain in joints of hand |
| M25.541 | Pain in joints of right hand |
| M25.542 | Pain in joints of left hand |
| M25.549 | Pain in joints of unspecified hand |
| M25.55 | Pain in hip |
| M25.551 | Pain in right hip |
| M25.552 | Pain in left hip |
| M25.559 | Pain in unspecified hip |
| M25.56 | Pain in knee |
| M25.561 | Pain in right knee |
| M25.562 | Pain in left knee |
| M25.569 | Pain in unspecified knee |
| M25.57 | Pain in ankle and joints of foot |
| M25.571 | Pain in right ankle and joints of right foot |
| M25.572 | Pain in left ankle and joints of left foot |
| M25.579 | Pain in unspecified ankle and joints of unspecified foot |
| M26.62 | Arthralgia of temporomandibular joint |
| M54.5 | Low back pain |
| M54.6 | Pain in thoracic spine |
| M79.6 | Pain in limb, hand, foot, fingers and toes |
| M79.60 | Pain in limb, unspecified |
| M79.601 | Pain in right arm |
| M79.602 | Pain in left arm |
| M79.603 | Pain in arm, unspecified |
| M79.604 | Pain in right leg |
| M79.605 | Pain in left leg |
| M79.606 | Pain in leg, unspecified |
| M79.609 | Pain in unspecified limb |
| M79.62 | Pain in upper arm |
| M79.621 | Pain in right upper arm |
| M79.622 | Pain in left upper arm |
| M79.629 | Pain in unspecified upper arm |
| M79.63 | Pain in forearm |
| M79.631 | Pain in right forearm |
| M79.632 | Pain in left forearm |
| M79.639 | Pain in unspecified forearm |
| M79.64 | Pain in hand and fingers |
| M79.641 | Pain in right hand |
| M79.642 | Pain in left hand |
| M79.643 | Pain in unspecified hand |
| M79.644 | Pain in right finger(s) |
| M79.645 | Pain in left finger(s) |
| M79.646 | Pain in unspecified finger(s) |
| M79.65 | Pain in thigh |
| M79.651 | Pain in right thigh |
| M79.652 | Pain in left thigh |
| M79.659 | Pain in unspecified thigh |
| M79.66 | Pain in lower leg |
| M79.661 | Pain in right lower leg |
| M79.662 | Pain in left lower leg |
| M79.669 | Pain in unspecified lower leg |
| M79.67 | Pain in foot and toes |
| M79.671 | Pain in right foot |
| M79.672 | Pain in left foot |
| M79.673 | Pain in unspecified foot |
| M79.674 | Pain in right toe(s) |
| M79.675 | Pain in left toe(s) |
| M79.676 | Pain in unspecified toe(s) |
| R07.82 | Intercostal pain |
| R10.0 | Acute abdomen |
| R10.1 | Pain localized to upper abdomen |
| R10.10 | Upper abdominal pain, unspecified |
| R10.11 | Right upper quadrant pain |
| R10.12 | Left upper quadrant pain |
| R10.2 | Pelvic and perineal pain |
| R10.3 | Pain localized to other parts of lower abdomen |
| R10.30 | Lower abdominal pain, unspecified |
| R10.31 | Right lower quadrant pain |
| R10.32 | Left lower quadrant pain |
| R10.33 | Periumbilical pain |
| R10.8 | Other abdominal pain |
| R10.84 | Generalized abdominal pain |
| R10.9 | Unspecified abdominal pain |
| R52 | Pain, unspecified |
| R68.84 | Jaw pain |
Formulary Reference Tool