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Drug overview for CRYOSERV (dimethyl sulfoxide):
Generic name: dimethyl sulfoxide
Drug class:
Therapeutic class: Chemicals-Pharmaceutical Adjuvants
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: dimethyl sulfoxide
Drug class:
Therapeutic class: Chemicals-Pharmaceutical Adjuvants
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
CRYOSERV SOLUTION
The following indications for CRYOSERV (dimethyl sulfoxide) have been approved by the FDA:
Indications:
None.
Professional Synonyms:
None.
Indications:
None.
Professional Synonyms:
None.
The following dosing information is available for CRYOSERV (dimethyl sulfoxide):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for CRYOSERV (dimethyl sulfoxide):
There are 1 contraindications.
These drug combinations generally should not be dispensed or administered to the same patient. A manufacturer label warning that indicates the contraindication warrants inclusion of a drug combination in this category, regardless of clinical evidence or lack of clinical evidence to support the contraindication.
| Drug Interaction | Drug Names |
|---|---|
| Sulindac/Dimethyl Sulfoxide (DMSO) SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: Dimethyl sulfoxide (DMSO) inhibits the bioactivation of sulindac to its active metabolite.(1,2) CLINICAL EFFECTS: Concurrent use of DMSO may result in decreased effectiveness of sulindac(1,2) and peripheral neuropathy.(1,3,4) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The US manufacturer of sulindac states that DMSO should not be used with sulindac.(1) DISCUSSION: In a study in 8 healthy male subjects, pretreatment with an oral dose of DMSO (30 ml of a 70% solution) 60 minutes before a single dose of sulindac (400 mg) decreased concentrations of the active sulfide metabolite of sulindac at 1.5, 2, 3, 4, 8, and 12 hours post dose. The area-under-curve (AUC) of the active sulfide metabolite was 30% lower (range 7% to 56%).(2) There are case reports of peripheral neuropathy during the concurrent use of sulindac and DMSO,(1,3,4) including one report with topical use of DMSO.(3) |
SULINDAC |
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for CRYOSERV (dimethyl sulfoxide):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 0 contraindications.
There are 0 severe contraindications.
There are 0 moderate contraindications.
The following adverse reaction information is available for CRYOSERV (dimethyl sulfoxide):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 9 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Anaphylaxis Angioedema Bronchospastic pulmonary disease Dermatitis due to topical drug Dyspnea Nasal congestion Pruritus of skin Skin rash Urticaria |
| Rare/Very Rare |
|---|
| None. |
There are 4 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Body odor Dysgeusia Halitosis Injection site sequelae |
| Rare/Very Rare |
|---|
| None. |
The following precautions are available for CRYOSERV (dimethyl sulfoxide):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for CRYOSERV (dimethyl sulfoxide):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for CRYOSERV (dimethyl sulfoxide)'s list of indications:
No ICD codes found for this drug.
No ICD codes found for this drug.
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