Orafate

Drug overview for ORAFATE (sucralfate malate, polymerized):

Generic name: SUCRALFATE MALATE, POLYMERIZED (soo-KRAL-fate)
Drug class: Mucous Membrane Protectants
Therapeutic class: Mouth-Throat-Dental - Preparations

Sucralfate, an anionic sulfated disaccharide, is an inhibitor of pepsin and an antiulcer agent that binds to the surface of ulcers, forming a protective barrier.

No enhanced Uses information available for this drug.

DRUG IMAGES

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The following indications for ORAFATE (sucralfate malate, polymerized) have been approved by the FDA:

Indications:
None.

Professional Synonyms:
None.

Drug Interaction	Drug Names
Lansoprazole/Sucralfate SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Sucralfate may decrease the absorption of lansoprazole.(3) CLINICAL EFFECTS: The simultaneous administration of sucralfate and lansoprazole may decrease the absorption of lansoprazole, which may result in therapeutic failures. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Lansoprazole should be taken at least 30 minutes prior to sucralfate.(1) DISCUSSION: In a single-dose crossover study, concurrent administration of lansoprazole (30 mg) with sucralfate (1 gram) resulted in delayed absorption of lansoprazole and a 17% reduction in lansoprazole's bioavailability.(1)	LANSOPRAZOL-AMOXICIL-CLARITHRO, LANSOPRAZOLE, PREVACID

The following precautions are available for ORAFATE (sucralfate malate, polymerized):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

Reproduction studies in mice, rats, and rabbits using sucralfate dosages up to 50 times the usual human dosage have not revealed evidence of harm to the fetus. There are no adequate and controlled studies to date using sucralfate in pregnant women, and the drug should be used during pregnancy only when clearly needed.

Since it is not known if sucralfate is distributed into milk, the drug should be used with caution in nursing women.

No enhanced Geriatric Use information available for this drug.