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KRAZATI (adagrasib)
- non-small cell lung cancer with KRAS G12C mutation
200 mg tablet
- 3 tablets (600 mg) by oral route 2 times per day
Default screening record
- 2 tablets (400 mg) by oral route 2 times per day
- 3 tablets (600 mg) by oral route 2 times per day
- 3 tablets (600 mg) by oral route once daily
- Advicor
- Altoprev
- avanafil
- Brilinta
- conivaptan in 5 % dextrose
- Detrol La
- disopyramide
- dronedarone
- droperidol
- eplerenone
- ezetimibe-simvastatin
- Inspra
- Latuda
- Levitra
- lovastatin
- lurasidone
- Mevacor
- midazolam
- Multaq
- niacin-lovastatin
- niacin-simvastatin
- Norpace
- Norpace Cr
- Orap
- pimozide
- Samsca
- Simcor
- simvastatin
- Stendra
- ticagrelor
- tolterodine
- tolvaptan
- triazolam
- Vaprisol
- vardenafil
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Zocor
Contraindicated
- A-methapred
- Abstral
- Actiq
- Advair Diskus
- Advair Hfa
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- Aristospan Intra-articular
- Aristospan Intralesional
- azelastine-fluticasone
- Breo Ellipta
- budesonide
- budesonide-formoterol
- deferiprone
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Duragesic
- Dymista
- Endocet
- Endodan
- Entocort Ec
- everolimus
- Ez Use Joint-tunnel-trigger
- Fareston
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Ferriprox
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fluticasone
- fluticasone furoate
- fluticasone-salmeterol
- fluticasone-vilanterol
- Geodon
- Hycamtin
- ibuprofen-oxycodone
- Invega
- Invega Sustenna
- Kenalog
- Lazanda
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- Nasacort
- Nasacort Aq
- nilotinib
- Olysio
- Orapred
- Orapred Odt
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- paliperidone
- paliperidone palmitate
- Pediapred
- Percocet
- Percodan
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Primlev
- propafenone
- Pulmicort
- Pulmicort Flexhaler
- Qualaquin
- quinine sulfate
- Rayos
- Rhinocort Aqua
- Roxicet
- Rythmol
- simeprevir
- Solu-medrol
- Solu-medrol (pf)
- Sublimaze (pf)
- Subsys
- Symbicort
- Tasigna
- topotecan
- toremifene
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Uceris
- Veramyst
- Veripred 20
- Xartemis Xr
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- Adcirca
- buspirone
- Cialis
- darifenacin
- Detrol
- Enablex
- fesoterodine
- ivacaftor
- Kalydeco
- Revatio
- sildenafil
- solifenacin
- tadalafil
- Toviaz
- Vesicare
- Viagra
- Congenital long QT syndrome
- Lactation
- Torsades de pointes
Contraindicated
- Abnormal hepatic function tests
- Interstitial lung disease
- Pregnancy
- Prolonged QT interval
Severe
Moderate
- Bradycardia
- Chronic heart failure
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
KRAZATI (adagrasib)
- non-small cell lung cancer with KRAS G12C mutation
- Anemia
- Drug-induced hepatitis
- Elevated serum lipase
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Increased alanine transaminase
- Increased alkaline phosphatase
- Kidney disease with reduction in GFR
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Anorexia
- Diarrhea
- Dyspnea
- Edema
- Fatigue
- Musculoskeletal pain
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Acute respiratory failure
- Gastrointestinal hemorrhage
- Gastrointestinal obstruction
- Heart failure
- Hypoxia
- Interstitial lung disease
- Interstitial pneumonitis
- Pleural effusions
- Pneumonia
- Prolonged QT interval
- Sepsis
- Altered mental status
- Cough
- Dehydration
- Dizziness
- Fever
- Hypotension
- Muscle weakness
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cerebrovascular accident
- Colitis
- Ileus
- Intestinal stenosis
- Pulmonary hemorrhage
- Pulmonary thromboembolism
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Adagrasib
Safety and effectiveness not established in pediatric patients.
- 1 Day – 18 Years
- Safety and effectiveness not established in pediatric patients.
Adagrasib
- Severity Level:
D
- Additional Notes: Insuff human data avail on dev tox risk; animal data sugg dev tox
Contraindicated
Adagrasib
Manuf does not rec breastfeeding during treatment and 1 wk after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Manuf does not rec breastfeeding during treatment and 1 wk after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Non-small cell lung cancer with KRAS g12C mutation | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool