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EXKIVITY (mobocertinib succinate)
- non-small cell lung cancer with EGFR exon 20 insertion
40 mg capsule
- 4 capsules (160 mg) by oral route once daily
Default screening record
- 2 capsules (80 mg) by oral route once daily
- 3 capsules (120 mg) by oral route once daily
- 4 capsules (160 mg) by oral route once daily
- artemether-lumefantrine
- Coartem
- disopyramide
- droperidol
- Geodon
- Norpace
- Norpace Cr
- Orap
- pimozide
- ziprasidone HCl
- ziprasidone mesylate
Contraindicated
- Fareston
- Invega
- Invega Sustenna
- paliperidone
- paliperidone palmitate
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- Rythmol
- Seroquel
- Seroquel Xr
- toremifene
Severe
Moderate
- fingolimod
- Gilenya
- Lactation
Contraindicated
- Chronic heart failure
- Congenital long QT syndrome
- Interstitial lung disease
- Pregnancy
- Prolonged QT interval
- Torsades de pointes
Severe
Moderate
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
EXKIVITY (mobocertinib succinate)
- non-small cell lung cancer with EGFR exon 20 insertion
- Anemia
- Elevated serum amylase
- Elevated serum lipase
- Hypokalemia
- Hypomagnesemia
- Lymphopenia
- Anorexia
- Diarrhea
- Dry skin
- Fatigue
- Musculoskeletal pain
- Nausea
- Paronychia
- Skin rash
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Atrial fibrillation
- Hypertension
- Kidney disease with reduction in GFR
- Pleural effusions
- Prolonged QT interval
- Acute abdominal pain
- Blurred vision
- Dry eye
- Dyspepsia
- Dyspnea
- Edema
- Fever
- Gastroesophageal reflux disease
- Headache disorder
- Palmar-plantar erythrodysesthesia
- Peripheral neuropathy
- Rhinorrhea
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Atrioventricular block
- Heart failure
- Interstitial lung disease
- Interstitial pneumonitis
- Left bundle branch block
- Supraventricular premature beats
- Torsades de pointes
- Ventricular premature beats
- Ventricular tachycardia
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Mobocertinib
Safety and effectiveness not established for pediatric patients.
- 1 Day – 18 Years
- Safety and effectiveness not established for pediatric patients.
Mobocertinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible
Contraindicated
Mobocertinib
Not rec during treatment and 1 week after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not rec during treatment and 1 week after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Mobocertinib
General-Exploratory analysis suggests a higher incidence of Grade 3 and 4 adverse reactions (69% vs 47%) and serious adverse reactions (64% vs 35%) in patients 65 years and older as compared to those younger than 65 years.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Mobocertinib may cause a condition that affects the heart rhythm (QT prolongation), which can lead to a serious (rarely fatal) fast/irregular heartbeat. Your doctor will monitor you closely before and during treatment with this medication. Keep all medical and lab appointments.<br /><br /> Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) since some drugs may also affect the heart rhythm (QT prolongation) or may increase the levels of this medication, which can increase the risk of side effects. See also Drug Interactions section.
| Non-small cell lung cancer with EGFR exon 20 insertion | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool