Provocholine

Drug overview for PROVOCHOLINE (methacholine chloride):

Generic name: METHACHOLINE CHLORIDE
Drug class:
Therapeutic class: Diagnostic Agents

No enhanced Introduction information available for this drug.

No enhanced Uses information available for this drug.

DRUG IMAGES

PROVOCHOLINE 100 MG VIAL
PROVOCHOLINE INHAL SOLN PACK
PROVOCHOLINE BASE 0 MG/3 ML VL
PROVOCHOLINE 0.1875 MG/3 ML VL
PROVOCHOLINE 0.75 MG/3 ML VIAL
PROVOCHOLINE 3 MG/3 ML VIAL
PROVOCHOLINE 12 MG/3 ML VIAL
PROVOCHOLINE 48 MG/3 ML VIAL

The following indications for PROVOCHOLINE (methacholine chloride) have been approved by the FDA:

Indications:
Diagnostic test for asthma

Professional Synonyms:
Diagnostic procedure for asthma

The following drug interaction information is available for PROVOCHOLINE (methacholine chloride):

Contraindicated
Severe
Moderate

There are 0 contraindications.

There are 0 severe interactions.

There are 1 moderate interactions. The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.

Drug Interaction	Drug Names
Methacholine/Beta-Agonists; Anticholinergics; Theophylline SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway.(1) CLINICAL EFFECTS: The result of the methacholine challenge test may not be accurate.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The following drugs should be held before a methacholine challenge for the the duration indicated:(1) - short-acting beta-agonists: 6 hours - long-acting beta-agonists: 36 hours - short-acting anti-cholinergics: 12 hours - long-acting anti-cholinergics: at least 168 hours (7 days) - oral theophylline: 12-48 hours DISCUSSION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway and cause inaccurate test results.	ADVAIR DISKUS, ADVAIR HFA, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, ALBUTEROL SULFATE, ALBUTEROL SULFATE HFA, AMINOPHYLLINE, ANORO ELLIPTA, ARFORMOTEROL TARTRATE, ATROVENT HFA, BEVESPI AEROSPHERE, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BROVANA, BUDESONIDE-FORMOTEROL FUMARATE, COMBIVENT RESPIMAT, CUVPOSA, DARTISLA, DUAKLIR PRESSAIR, DULERA, ELIXOPHYLLIN, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, FORMOTEROL FUMARATE, GLYCATE, GLYCOPYRROLATE, GLYCOPYRROLATE-STERILE WATER, GLYCOPYRROLATE-WATER, GLYRX-PF, INCRUSE ELLIPTA, IPRATROPIUM BROMIDE, IPRATROPIUM-ALBUTEROL, ISOPROTERENOL HCL, ISOPROTERENOL HCL-0.9% NACL, ISUPREL, LEVALBUTEROL CONCENTRATE, LEVALBUTEROL HCL, LEVALBUTEROL TARTRATE HFA, PERFOROMIST, PREVDUO, PROAIR DIGIHALER, PROAIR RESPICLICK, ROBINUL, ROBINUL FORTE, SEREVENT DISKUS, SPIRIVA HANDIHALER, SPIRIVA RESPIMAT, STIOLTO RESPIMAT, STRIVERDI RESPIMAT, SYMBICORT, TERBUTALINE SULFATE, THEO-24, THEOPHYLLINE, THEOPHYLLINE ANHYDROUS, THEOPHYLLINE ER, THEOPHYLLINE ETHYLENEDIAMINE, TIOTROPIUM BROMIDE, TRELEGY ELLIPTA, TUDORZA PRESSAIR, UMECLIDINIUM-VILANTEROL, VENTOLIN HFA, WIXELA INHUB, XOPENEX HFA, YUPELRI

Drug Interaction

Drug Names

Methacholine/Beta-Agonists; Anticholinergics; Theophylline

SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.

MECHANISM OF ACTION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway.(1)

CLINICAL EFFECTS: The result of the methacholine challenge test may not be accurate.(1)

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: The following drugs should be held before a methacholine challenge for the the duration indicated:(1) - short-acting beta-agonists: 6 hours - long-acting beta-agonists: 36 hours - short-acting anti-cholinergics: 12 hours - long-acting anti-cholinergics: at least 168 hours (7 days) - oral theophylline: 12-48 hours

DISCUSSION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway and cause inaccurate test results.

ADVAIR DISKUS, ADVAIR HFA, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, ALBUTEROL SULFATE, ALBUTEROL SULFATE HFA, AMINOPHYLLINE, ANORO ELLIPTA, ARFORMOTEROL TARTRATE, ATROVENT HFA, BEVESPI AEROSPHERE, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BROVANA, BUDESONIDE-FORMOTEROL FUMARATE, COMBIVENT RESPIMAT, CUVPOSA, DARTISLA, DUAKLIR PRESSAIR, DULERA, ELIXOPHYLLIN, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, FORMOTEROL FUMARATE, GLYCATE, GLYCOPYRROLATE, GLYCOPYRROLATE-STERILE WATER, GLYCOPYRROLATE-WATER, GLYRX-PF, INCRUSE ELLIPTA, IPRATROPIUM BROMIDE, IPRATROPIUM-ALBUTEROL, ISOPROTERENOL HCL, ISOPROTERENOL HCL-0.9% NACL, ISUPREL, LEVALBUTEROL CONCENTRATE, LEVALBUTEROL HCL, LEVALBUTEROL TARTRATE HFA, PERFOROMIST, PREVDUO, PROAIR DIGIHALER, PROAIR RESPICLICK, ROBINUL, ROBINUL FORTE, SEREVENT DISKUS, SPIRIVA HANDIHALER, SPIRIVA RESPIMAT, STIOLTO RESPIMAT, STRIVERDI RESPIMAT, SYMBICORT, TERBUTALINE SULFATE, THEO-24, THEOPHYLLINE, THEOPHYLLINE ANHYDROUS, THEOPHYLLINE ER, THEOPHYLLINE ETHYLENEDIAMINE, TIOTROPIUM BROMIDE, TRELEGY ELLIPTA, TUDORZA PRESSAIR, UMECLIDINIUM-VILANTEROL, VENTOLIN HFA, WIXELA INHUB, XOPENEX HFA, YUPELRI

The following contraindication information is available for PROVOCHOLINE (methacholine chloride):

Overview
Contraindicated
Severe
Moderate

Drug contraindication overview.

No enhanced Contraindications information available for this drug.

There are 4 contraindications. Absolute contraindication.

Contraindication List
30 day risk period post-myocardial infarction
Aortic aneurysm
Cerebrovascular accident
Pregnancy

There are 5 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Bradycardia
Increased gastric tonus
Peptic ulcer
Seizure disorder
Urinary tract obstructive uropathy

There are 0 moderate contraindications.

The following adverse reaction information is available for PROVOCHOLINE (methacholine chloride):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 3 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Bronchospastic pulmonary disease Dyspnea Wheezing

There are 6 less severe adverse reactions.

More Frequent	Less Frequent
None.	Dizziness Headache disorder Pharyngitis

Rare/Very Rare
Chest tightness Cough Pruritus of skin

The following precautions are available for PROVOCHOLINE (methacholine chloride):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

No enhanced Pregnancy information available for this drug.

No enhanced Lactation information available for this drug.

No enhanced Geriatric Use information available for this drug.