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ZOLINZA (VORINOSTAT)
- Cutaneous t-cell lymphoma
100 mg capsule
- 4 capsules (400 mg) by oral route once daily
Cutaneous t-cell lymphoma
- 3 capsules (300 mg) by oral route once daily
- 3 capsules (300 mg) by oral route once daily for 5 consecutive days each week
- 4 capsules (400 mg) by oral route once daily
- natalizumab
- Tysabri
Contraindicated
- Buphenyl
- Coumadin
- Depacon
- Depakene
- Depakote
- Depakote Er
- Depakote Sprinkles
- divalproex
- Istodax
- Jantoven
- romidepsin
- sodium phenylbutyrate
- Stavzor
- valproate sodium
- valproic acid
- valproic acid (as sodium salt)
- warfarin
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Congenital long QT syndrome
- Deep venous thrombosis
- Dehydration
- Disease of liver
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Pregnancy
- Prolonged QT interval
- Pulmonary thromboembolism
- Vomiting
Severe
Moderate
- Anemia
- Diabetes mellitus
- Diarrhea
- Hypertension
- Thrombocytopenic disorder
ZOLINZA (VORINOSTAT)
- Cutaneous t-cell lymphoma
- Anemia
- Chills
- Kidney disease with reduction in GFR
- Peripheral edema
- Thrombocytopenic disorder
- Alopecia
- Anorexia
- Constipation
- Diarrhea
- Dizziness
- Dysgeusia
- Fatigue
- Muscle spasm
- Nausea
- Vomiting
- Weight loss
- Xerostomia
More Frequent
Severe
Less Severe
- Dehydration
- Pulmonary thromboembolism
- Squamous cell carcinoma
- Cough
- Fever
- Headache disorder
- Pruritus of skin
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cerebrovascular accident
- Chest pain
- Deep venous thrombosis
- Exfoliative dermatitis
- Gastrointestinal hemorrhage
- Hyperglycemia
- Hypokalemia
- Leukopenia
- Neutropenic disorder
- Prolonged QT interval
- Proteinuria
Less Severe
- General weakness
- Lethargy
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Vorinostat
Safety and efficacy not established age <18 years.
- 1 Day – 18 Years
- Safety and efficacy not established age <18 years.
Vorinostat
- Severity Level:
D
- Additional Notes: Theoretical risk based on drug mechanism of action.
Contraindicated
Vorinostat
Insuff human data; excretion possible mw low; risk of serious adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data; excretion possible mw low; risk of serious adverse effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Cutaneous t-cell lymphoma | |
| C84.0 | Mycosis fungoides |
| C84.00 | Mycosis fungoides, unspecified site |
| C84.01 | Mycosis fungoides, lymph nodes of head, face, and neck |
| C84.02 | Mycosis fungoides, intrathoracic lymph nodes |
| C84.03 | Mycosis fungoides, intra-abdominal lymph nodes |
| C84.04 | Mycosis fungoides, lymph nodes of axilla and upper limb |
| C84.05 | Mycosis fungoides, lymph nodes of inguinal region and lower limb |
| C84.06 | Mycosis fungoides, intrapelvic lymph nodes |
| C84.07 | Mycosis fungoides, spleen |
| C84.08 | Mycosis fungoides, lymph nodes of multiple sites |
| C84.09 | Mycosis fungoides, extranodal and solid organ sites |
| C84.1 | Sezary disease |
| C84.10 | Sezary disease, unspecified site |
| C84.11 | Sezary disease, lymph nodes of head, face, and neck |
| C84.12 | Sezary disease, intrathoracic lymph nodes |
| C84.13 | Sezary disease, intra-abdominal lymph nodes |
| C84.14 | Sezary disease, lymph nodes of axilla and upper limb |
| C84.15 | Sezary disease, lymph nodes of inguinal region and lower limb |
| C84.16 | Sezary disease, intrapelvic lymph nodes |
| C84.17 | Sezary disease, spleen |
| C84.18 | Sezary disease, lymph nodes of multiple sites |
| C84.19 | Sezary disease, extranodal and solid organ sites |
| C84.A | Cutaneous t-cell lymphoma, unspecified |
| C84.A0 | Cutaneous t-cell lymphoma, unspecified, unspecified site |
| C84.A1 | Cutaneous t-cell lymphoma, unspecified lymph nodes of head, face, and neck |
| C84.A2 | Cutaneous t-cell lymphoma, unspecified, intrathoracic lymph nodes |
| C84.A3 | Cutaneous t-cell lymphoma, unspecified, intra-abdominal lymph nodes |
| C84.A4 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of axilla and upper limb |
| C84.A5 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
| C84.A6 | Cutaneous t-cell lymphoma, unspecified, intrapelvic lymph nodes |
| C84.A7 | Cutaneous t-cell lymphoma, unspecified, spleen |
| C84.A8 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of multiple sites |
| C84.A9 | Cutaneous t-cell lymphoma, unspecified, extranodal and solid organ sites |
| C86.6 | Primary cutaneous Cd30-positive t-cell proliferations |
| 0-9 | A-Z |
|---|---|
| C84.0 | Mycosis fungoides |
| C84.00 | Mycosis fungoides, unspecified site |
| C84.01 | Mycosis fungoides, lymph nodes of head, face, and neck |
| C84.02 | Mycosis fungoides, intrathoracic lymph nodes |
| C84.03 | Mycosis fungoides, intra-abdominal lymph nodes |
| C84.04 | Mycosis fungoides, lymph nodes of axilla and upper limb |
| C84.05 | Mycosis fungoides, lymph nodes of inguinal region and lower limb |
| C84.06 | Mycosis fungoides, intrapelvic lymph nodes |
| C84.07 | Mycosis fungoides, spleen |
| C84.08 | Mycosis fungoides, lymph nodes of multiple sites |
| C84.09 | Mycosis fungoides, extranodal and solid organ sites |
| C84.1 | Sezary disease |
| C84.10 | Sezary disease, unspecified site |
| C84.11 | Sezary disease, lymph nodes of head, face, and neck |
| C84.12 | Sezary disease, intrathoracic lymph nodes |
| C84.13 | Sezary disease, intra-abdominal lymph nodes |
| C84.14 | Sezary disease, lymph nodes of axilla and upper limb |
| C84.15 | Sezary disease, lymph nodes of inguinal region and lower limb |
| C84.16 | Sezary disease, intrapelvic lymph nodes |
| C84.17 | Sezary disease, spleen |
| C84.18 | Sezary disease, lymph nodes of multiple sites |
| C84.19 | Sezary disease, extranodal and solid organ sites |
| C84.A | Cutaneous t-cell lymphoma, unspecified |
| C84.A0 | Cutaneous t-cell lymphoma, unspecified, unspecified site |
| C84.A1 | Cutaneous t-cell lymphoma, unspecified lymph nodes of head, face, and neck |
| C84.A2 | Cutaneous t-cell lymphoma, unspecified, intrathoracic lymph nodes |
| C84.A3 | Cutaneous t-cell lymphoma, unspecified, intra-abdominal lymph nodes |
| C84.A4 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of axilla and upper limb |
| C84.A5 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
| C84.A6 | Cutaneous t-cell lymphoma, unspecified, intrapelvic lymph nodes |
| C84.A7 | Cutaneous t-cell lymphoma, unspecified, spleen |
| C84.A8 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of multiple sites |
| C84.A9 | Cutaneous t-cell lymphoma, unspecified, extranodal and solid organ sites |
| C86.6 | Primary cutaneous Cd30-positive t-cell proliferations |
Formulary Reference Tool