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LIORESAL INTRATHECAL (BACLOFEN)
- Muscle spasticity of cerebral origin
- Muscle spasticity of spinal origin
Lioresal 2,000 mcg/mL intrathecal solution
- Infuse 3.75 mcg/hour (90 mcg/day) by cont intrathecal inf route
Lioresal 50 mcg/mL intrathecal solution
- Infuse 3.75 mcg/hour (90 mcg/day) by cont intrathecal inf route
Lioresal 500 mcg/mL intrathecal solution
- Dosage information is not available
Muscle spasticity of cerebral origin
- Infuse 3.75 mcg/hour (90 mcg/day) by cont intrathecal inf route
- Infuse 29.3 mcg/hour (703 mcg/day) by cont intrathecal inf route
- None
Contraindicated
- None
Severe
Moderate
- None
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Kidney disease with likely reduction in GFR
Severe
Moderate
- Acute confusion
- Autonomic dysreflexia
- Autonomic neuropathy
- Psychotic disorder
- Schizophrenia
LIORESAL INTRATHECAL (BACLOFEN)
- Muscle spasticity of cerebral origin
- Muscle spasticity of spinal origin
- Seizure disorder
- Constipation
- Dizziness
- Drowsy
- Headache disorder
- Hypotonia
- Nausea
- Paresthesia
- Vomiting
More Frequent
Severe
Less Severe
- Pneumonia
- Acute confusion
- Administration site infection
- Agitation
- Ataxia
- Chills
- Diarrhea
- Dysphasia
- Dyspnea
- Edema
- Erectile dysfunction
- Hypotension
- Increased urinary frequency
- Insomnia
- Leukocytosis
- Nystagmus
- Pain
- Peripheral edema
- Pruritus of skin
- Tremor
- Urinary incontinence
- Urinary retention
- Urticaria
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abrupt drug withdrawal causing life-threatening sequelae
- Anemia
- Apnea
- Coma
- Depression
- General weakness
- Hallucinations
- Hypertension
- Hyperventilation
- Syncope
- Tinnitus
- Visual changes
Less Severe
- Acute abdominal pain
- Alopecia
- Anorexia
- Diplopia
- Dysarthria
- Fever
- Flatulence
- Gait abnormality
- Hyperhidrosis
- Symptoms of anxiety
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Baclofen
Safety and efficacy not established age <4 years.
- 1 Day – 4 Years
- Safety and efficacy not established age <4 years.
Baclofen
- Severity Level:
C
- Additional Notes: Insuff. human data; increased incidence of omphalocele in rats at 3 times mrhd
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Baclofen
Limited data suggest amount excreted is minimal, may cause sedation in infant
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest amount excreted is minimal, may cause sedation in infant |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Do not stop using this medication without consulting your doctor. Serious (rarely fatal) withdrawal problems may occur if this medication is suddenly stopped. Get medical help right away if you have any signs of a withdrawal reaction, including: itching, numb/tingling skin, high fever, mental/mood changes (such as confusion), seizures, worsening muscle tightness/stiffness, signs of kidney problems (such as change in the amount of urine).<br /><br />Tell your doctor if you ever had a withdrawal reaction from baclofen. Keep all appointments for refilling the pump to avoid any serious withdrawal problems. Your doctor or another health care professional will check that the pump is programmed and working properly during these appointments.<br /><br />If you must miss a refill appointment, contact your doctor right away to reschedule the appointment before you run out of medication. Also, learn what your pump alarm sounds like. If you hear the alarm, contact your doctor right away.
Muscle spasticity of cerebral origin | |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
Muscle spasticity of spinal origin | |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
0-9 | A-Z |
---|---|
M62.83 | Muscle spasm |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
R25.2 | Cramp and spasm |
Formulary Reference Tool