DIABETIC TUSSIN NIGHT TIME (dextromethorphan hbr/acetaminophen/diphenhydramine hcl)


Drug overview for DIABETIC TUSSIN NIGHT TIME (dextromethorphan hbr/acetaminophen/diphenhydramine hcl):

Generic name: dextromethorphan HBr/acetaminophen/diphenhydramine HCl
Drug class: Antitussives
Therapeutic class: Respiratory Therapy Agents

Acetaminophen is a synthetic nonopiate derivative of p-aminophenol that Dextromethorphan, a derivative of levorphanol, is an antitussive agent. Diphenhydramine is an ethanolamine-derivative, first generation antihistamine. produces analgesia and antipyresis.

Acetaminophen is used extensively in the treatment of mild to moderate pain Dextromethorphan is used for the temporary relief of coughs caused by minor Diphenhydramine shares the actions and uses of other antihistamines. and fever. throat and bronchial irritation such as may occur with common colds or with Diphenhydramine also is used as an antitussive for temporary relief of inhaled irritants.

Dextromethorphan is most effective in the treatment of chronic, nonproductive cough. The drug is a common ingredient in commercial cough caused by minor throat and bronchial irritation such as may occur cough mixtures available without prescription. with common colds or inhaled irritants.

Although cough and cold preparations that contain cough suppressants Diphenhydramine is effective for the prevention and treatment of nausea, (including dextromethorphan), nasal decongestants, antihistamines, and/or vomiting, and/or vertigo associated with motion sickness. expectorants commonly are used in pediatric patients younger than 2 years Diphenhydramine may be useful as an adjunctive antiemetic agent to prevent of age, systematic reviews of controlled trials have concluded that chemotherapy-induced nausea and vomiting+; however, the American Society of nonprescription (over-the-counter, OTC) cough and cold preparations are not Clinical Oncology (ASCO) currently does not recommend that antihistamines more effective than placebo in reducing acute cough and other symptoms of be used alone as antiemetic agents in patients receiving chemotherapy. upper respiratory tract infection in these patients.

Furthermore, adverse events, including deaths, have been (and continue to be) reported in Diphenhydramine also is used as a nighttime sleep aid for the short-term pediatric patients younger than 2 years of age receiving these management of insomnia. In individuals who experience occasional preparations. (See Cautions: Pediatric Precautions and see Acute Toxicity: Manifestations.) sleeplessness or those who have difficulty falling asleep, the drug is more effective than placebo in reducing sleep onset (i.e., time to fall asleep) and increasing the depth and quality of sleep.

For information on abuse of dextromethorphan, see Cautions. Diphenhydramine, alone or in conjunction with other antiparkinsonian For use of dextromethorphan hydrobromide in fixed combination with agents, may be useful as alternative therapy in the management of tremor quinidine sulfate in the treatment of pseudobulbar affect (PBA), see Dextromethorphan Hydrobromide and Quinidine Sulfate 28:92. early in the course of parkinsonian syndrome.

The drug also may be useful in the management of drug-induced extrapyramidal reactions. Diphenhydramine may be used topically for temporary relief of pruritus and pain associated with various skin conditions including minor burns, sunburn, minor cuts or scrapes, insect bites, minor skin irritations, or rashes associated with poison oak, poison ivy, or poison sumac. However, because systemic diphenhydramine toxicity (e.g., psychosis) has been reported in pediatric patients following topical application of the drug to large areas of the body (often areas with broken skin), many clinicians suggest that topical diphenhydramine be used only on limited areas of skin and not used more often than directed to avoid excessive percutaneous absorption of the drug.

(See Acute Toxicity: Manifestations, in the Antihistamines General Statement 4:00.) Topical diphenhydramine also should not be used for self-medication in the management of varicella (chickenpox) or measles without first consulting a clinician.
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The following indications for DIABETIC TUSSIN NIGHT TIME (dextromethorphan hbr/acetaminophen/diphenhydramine hcl) have been approved by the FDA:

Indications:
Allergic rhinitis
Cold symptoms
Cough
Fever
Flu-like symptoms
Headache disorder
Nasal congestion
Rhinorrhea
Sneezing
Sore throat


Professional Synonyms:
Burning sensation of throat
Cephalgia
Cephalodynia
Febrile reaction
Febrile
Nasal stuffiness
Pharyngeal pain
Pharyngeal soreness
Pyrexia
Sore throat symptom