NEO-SYNALAR (neomycin sulfate/fluocinolone acetonide)

There are 0 contraindications.

There are 2 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Bacterial skin and skin structure infection
Severe burns

There are 2 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Hypothalamic-pituitary insufficiency
Large open wound

There are 20 severe adverse reactions.

More Frequent	Less Frequent
Dermatitis due to topical drug Skin rash	Folliculitis Purpura Skin and skin structure infection Skin atrophy

Rare/Very Rare
Adrenocortical insufficiency Bullous dermatitis Cataracts Central serous chorioretinopathy Glaucoma Growth failure Hypothalamic-pituitary insufficiency Intracranial hypertension Ocular hypertension Ototoxicity Skin hypopigmentation Skin striae Skin ulcer Urticaria

There are 24 less severe adverse reactions.

More Frequent	Less Frequent
Erythema Stinging of skin	Acute pain at drug application site Blurred vision Headache disorder Paresthesia Pruritus of skin Skin rash Telangiectasia Treatment site sequelae

Rare/Very Rare
Acneiform eruption Alopecia Blistering skin Contact dermatitis Dry skin Dyschromia Glycosuria Hirsutism Hypercortisolism Hyperesthesia Hyperglycemia Miliaria Perioral dermatitis Skin irritation

Aminoglycosides may cause fetal harm following systemic absorption in pregnant women. The drugs cross the placenta and total, irreversible, bilateral, congenital deafness has been reported in some children whose mothers received parenteral streptomycin during pregnancy. Fixed-combination topical preparations containing neomycin sulfate and a corticosteroid should be used during pregnancy only if potential benefits justify potential risks to the fetus.

Corticosteroids have been teratogenic in animals (mice, rabbits) when applied topically. If the irrigation solution containing neomycin sulfate and polymyxin B sulfate is used for bladder irrigation during pregnancy, the patient should be informed of the potential hazard to the fetus.

Clinically unimportant amounts of neomycin may distribute into breast milk following systemic absorption of the drug. Fixed-combination topical preparations containing neomycin sulfate and a corticosteroid should be used with caution in nursing women. Corticosteroids administered systemically (e.g., orally) are distributed into human milk, and systemic absorption may occur when the drugs are applied topically.

No enhanced Geriatric Use information available for this drug.