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AGGRASTAT (TIROFIBAN HCL MONOHYDRATE)
- Acute coronary syndrome
- PCI adjunct for thrombosis prevention
- Non q-wave myocardial infarction
- Unstable angina pectoris
12.5 mg/250 mL (50 mcg/mL) in iso-osmotic sodium chloride IV
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
5 mg/100 mL (50 mcg/mL) in 0.9 % sodium chloride IV
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
Concentrate 250 mcg/mL intravenous
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route once
Acute coronary syndrome
- Infuse 0.4 mcg/kg/minute by intravenous route for 30 minutes and thencontinue at 0.1 mcg/kg/min
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route once
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
- Infuse 0.15 mcg/kg/minute by intravenous route for up to 18 hours
Non q-wave myocardial infarction
- Infuse 0.4 mcg/kg/minute by intravenous route for 30 minutes and thencontinue at 0.1 mcg/kg/min
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route once
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
- Infuse 0.15 mcg/kg/minute by intravenous route for up to 18 hours
PCI adjunct for thrombosis prevention
- Infuse 0.4 mcg/kg/minute by intravenous route for 30 minutes and thencontinue at 0.1 mcg/kg/min
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route once
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
- Infuse 0.15 mcg/kg/minute by intravenous route for up to 18 hours
Unstable angina pectoris
- Infuse 0.4 mcg/kg/minute by intravenous route for 30 minutes and thencontinue at 0.1 mcg/kg/min
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route once
- Infuse 25 mcg/kg over 5 minutes or less by intravenous route and thencontinue at 0.15 mcg/kg/minute for up to 18 hours
- Infuse 0.15 mcg/kg/minute by intravenous route for up to 18 hours
- Mifeprex
- mifepristone
Contraindicated
- apixaban
- Aptivus
- Eliquis
- rivaroxaban
- tipranavir
- Xarelto
Severe
Moderate
- Activase
- alteplase
- Arixtra
- Brintellix
- Brisdelle
- Celexa
- citalopram
- Coumadin
- Cymbalta
- dalteparin (porcine)
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- duloxetine
- Effexor Xr
- Elmiron
- enoxaparin
- eptifibatide
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- fondaparinux
- Fragmin
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Integrilin
- Jantoven
- Khedezla
- lepirudin
- levomilnacipran
- Lexapro
- Lovenox
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- pentosan polysulfate sodium
- Pexeva
- Pristiq
- Prozac
- Prozac Weekly
- Refludan
- Retavase
- reteplase
- Sarafem
- Savella
- sertraline
- Symbyax
- tenecteplase
- Tnkase
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- warfarin
- Zoloft
- Acute pericarditis
- Aortic aneurysm with dissection
- Arterial aneurysm
- Arteriovenous malformation
- Cerebrovascular accident
- Hemorrhage
- Increased risk of bleeding due to coagulation disorder
- Intracranial bleeding
- Invasive surgical procedure
- Major traumatic injury
- Neoplasm of brain
- Severe uncontrolled hypertension
Contraindicated
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Hemodialysis with high-flux membrane
- Hemorrhagic diabetic retinopathy
- Lithotripsy
- Thrombocytopenic disorder
Severe
Moderate
- None
AGGRASTAT (TIROFIBAN HCL MONOHYDRATE)
- Acute coronary syndrome
- PCI adjunct for thrombosis prevention
- Non q-wave myocardial infarction
- Unstable angina pectoris
- Hemorrhage
- None
More Frequent
Severe
Less Severe
- Coronary artery dissection
- Vagal reflex bradycardia
- Bloody stools
- Bradycardia
- Dizziness
- Edema
- Fever
- Headache disorder
- Hematuria
- Hyperhidrosis
- Limb pain
- Nausea
- Pelvic pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Gastrointestinal hemorrhage
- Genitourinary tract hemorrhage
- Hypersensitivity drug reaction
- Intracranial bleeding
- Pulmonary hemorrhage
- Thrombocytopenic disorder
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tirofiban
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Tirofiban
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tirofiban
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tirofiban
General-Greater risk of bleeding in geriatric patients with or without heparin. Renal-Decreased plasma clearance of tirofiban in patients with moderate to severe renal insufficiency.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Acute coronary syndrome | |
| I20.0 | Unstable angina |
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
| I24 | Other acute ischemic heart diseases |
| I24.0 | Acute coronary thrombosis not resulting in myocardial infarction |
| I24.9 | Acute ischemic heart disease, unspecified |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| Non q-wave myocardial infarction | |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| Unstable angina pectoris | |
| I20.0 | Unstable angina |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| 0-9 | A-Z |
|---|---|
| I20.0 | Unstable angina |
| I20.0 | Unstable angina |
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.9 | Acute myocardial infarction, unspecified |
| I21.A | Other type of myocardial infarction |
| I21.A1 | Myocardial infarction type 2 |
| I21.A9 | Other myocardial infarction type |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
| I24 | Other acute ischemic heart diseases |
| I24.0 | Acute coronary thrombosis not resulting in myocardial infarction |
| I24.9 | Acute ischemic heart disease, unspecified |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
Formulary Reference Tool