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Drug overview for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
Generic name: VIT C/CHERRY EXT/CELERY SEED EXT/CELERY SEED/GRAPE SEED EXT
Drug class:
Therapeutic class: Electrolyte Balance-Nutritional Products
Ascorbic acid is the functional and principal in vivo form of vitamin C, an essential water-soluble vitamin.
No enhanced Uses information available for this drug.
Generic name: VIT C/CHERRY EXT/CELERY SEED EXT/CELERY SEED/GRAPE SEED EXT
Drug class:
Therapeutic class: Electrolyte Balance-Nutritional Products
Ascorbic acid is the functional and principal in vivo form of vitamin C, an essential water-soluble vitamin.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext) have been approved by the FDA:
Indications:
None.
Professional Synonyms:
None.
Indications:
None.
Professional Synonyms:
None.
The following dosing information is available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
No enhanced Dosing information available for this drug.
Ascorbic acid is usually administered orally. When oral administration is not feasible or when malabsorption is suspected, the drug may be administered IM, IV, or subcutaneously. When given parenterally, utilization of the vitamin reportedly is best after IM administration and that is the preferred parenteral route.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
There are 0 contraindications.
There are 1 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Bortezomib/Ascorbic Acid (Vitamin C) SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Vitamin C can form a complex with the boronic acid moiety of the bortezomib molecule, preventing its absorption into cells.(1-4) This may protect normal tissue in the body, which may have higher levels of Vitamin C.(5) CLINICAL EFFECTS: Concurrent administration of Vitamin C may result in decreased bortezomib activity.(1-4) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Instruct patients receiving bortezomib therapy not to begin taking vitamin C supplements without consulting their oncologist first. Patients who are instructed to take vitamin C should follow their oncologist's instructions on how to separate dosages and should be carefully monitored for bortezomib efficacy. DISCUSSION: An in vitro study with human plasma and multiple myeloma cells found that high levels of vitamin C (following 1 gram/day of ascorbic acid for 4 days) decreased bortezomib effectiveness by 26%. An in vivo study in mice found that vitamin C administration with bortezomib completely blocked the response of bortezomib.(6) An in vitro study in rat Schwann cells and myeloma cells(4) and an in vivo study in mice(7) found that delayed administration of vitamin C had no effect on bortezomib effects. In an in vivo study in multiple myeloma patients, concurrent ascorbic acid, arsenic trioxide, bortezomib, and high-dose melphalan in which ascorbic acid was administered close to bortezomib, the combination was safe and well tolerated, but produced no changes in response rates.(8) In another in vivo study in multiple myeloma patients, a regimen of ascorbic acid, bortezomib, and melphalan in which bortezomib was administered in the morning and ascorbic acid in the evening was found to be safe and efficacious, with 74% of patients responding to therapy.(9) |
BORTEZOMIB, BORUZU, VELCADE |
There are 0 moderate interactions.
The following contraindication information is available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 0 contraindications.
There are 0 severe contraindications.
There are 0 moderate contraindications.
The following adverse reaction information is available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 1 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Hypersensitivity drug reaction |
There are 6 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Acute abdominal pain Alopecia Headache disorder Pain in oropharynx Pharyngitis Skin rash |
The following precautions are available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for TART CHERRY (vit c/cherry ext/celery seed ext/celery seed/grape seed ext)'s list of indications:
No ICD codes found for this drug.
No ICD codes found for this drug.
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