EFFIENT (PRASUGREL HCL)
- Myocardial reinfarction prevention
- Thrombosis prevention after PCI
prasugrel 10 mg tablet
- 1 tablet (10 mg) by oral route once daily
prasugrel 5 mg tablet
- 1 tablet (5 mg) by oral route once daily
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
5 mg tablet
- 1 tablet (5 mg) by oral route once daily
Myocardial reinfarction prevention
- 1 tablet (5 mg) by oral route once daily
- 2 tablets (10 mg) by oral route once daily
- 1 tablet (10 mg) by oral route once daily
Thrombosis prevention after PCI
- 1 tablet (5 mg) by oral route once daily
- 2 tablets (10 mg) by oral route once daily
- 1 tablet (10 mg) by oral route once daily
- Mifeprex
- mifepristone
Contraindicated
- apixaban
- Aptivus
- Eliquis
- rivaroxaban
- tipranavir
- Xarelto
Severe
Moderate
- abciximab
- Activase
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- alteplase
- Anaprox
- Anaprox Ds
- Ansaid
- Arixtra
- Arthrotec 50
- Brintellix
- Brisdelle
- Caldolor
- Cambia
- Cataflam
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- citalopram
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Coumadin
- Cymbalta
- dalteparin (porcine)
- Daypro
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Duexis
- duloxetine
- Ec-naprosyn
- Effexor Xr
- Elmiron
- enoxaparin
- eptifibatide
- escitalopram oxalate
- etodolac
- Feldene
- fenoprofen
- Fetzima
- Flanax
- Flector
- fluoxetine
- flurbiprofen
- fluvoxamine
- fondaparinux
- Fragmin
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- Jantoven
- ketoprofen
- ketorolac
- Khedezla
- lepirudin
- levomilnacipran
- Lexapro
- Lovenox
- Luvox Cr
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- milnacipran
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- olanzapine-fluoxetine
- oxaprozin
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pennsaid
- pentosan polysulfate sodium
- Pexeva
- piroxicam
- Ponstel
- Pristiq
- Provil
- Prozac
- Prozac Weekly
- pseudoephedrine-ibuprofen
- Refludan
- Reopro
- Reprexain
- Retavase
- reteplase
- Sarafem
- Savella
- sertraline
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- Symbyax
- tenecteplase
- Tnkase
- tolmetin
- venlafaxine
- Vicoprofen
- Viibryd
- vilazodone
- Vimovo
- Voltaren-xr
- vortioxetine
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- warfarin
- Zipsor
- Zoloft
- Zorvolex
- Cerebrovascular accident
- Deep peripheral nerve block
- Deep plexus block
- Intracranial bleeding
- Invasive procedure on spine
- Neuraxial anesthesia
- Placement of indwelling epidural catheter
- Transient cerebral ischemia
Contraindicated
- Coronary artery bypass graft procedure
- Hemorrhage
- Increased risk of bleeding
- Invasive surgical procedure
- Major traumatic injury
- Peptic ulcer
Severe
Moderate
- Severe hepatic disease
- Thrombotic thrombocytopenic purpura
EFFIENT (PRASUGREL HCL)
- Myocardial reinfarction prevention
- Thrombosis prevention after PCI
- Epistaxis
- Hypertension
- Bruising
- Headache disorder
- Hyperlipidemia
More Frequent
Severe
Less Severe
- Anemia
- Atrial fibrillation
- Dyspnea
- Gastrointestinal hemorrhage
- Hemorrhage
- Back pain
- Bradycardia
- Cough
- Diarrhea
- Dizziness
- Fatigue
- Hypotension
- Nausea
- Non-cardiac chest pain
- Pain
- Peripheral edema
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Hypersensitivity drug reaction
- Intracranial bleeding
- Leukopenia
- Pericardial effusion
- Retinal hemorrhage
- Retroperitoneal hemorrhage
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
Less Severe
- Fever
- Hematoma
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Prasugrel
No reduction of vaso-occlusive crisis observed in study of pediatric sickle cell patients. Safety and efficacy not established in pediatrics.
- 1 Day – 18 Years
- No reduction of vaso-occlusive crisis observed in study of pediatric sickle cell patients. Safety and efficacy not established in pediatrics.
Prasugrel
- Severity Level:
2
- Additional Notes: Insufficient human data available; consider maternal tx benefit vs. risks
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Prasugrel
Insufficient human data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Prasugrel
General-Increased risk of serious and fatal bleeding in persons older than 74 years of age or weight less than 60 kilograms. Consider lower dose of 5 mg/day for those >74 years old. Weigh risk- benefit for use in acute coronary syndrome intervention.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Prasugrel can rarely cause very serious (possibly fatal) bleeding. Tell your doctor right away if you notice any signs of serious bleeding. See also Side Effects and Precautions sections.
Myocardial reinfarction prevention | |
I21 | Acute myocardial infarction |
I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
I21.9 | Acute myocardial infarction, unspecified |
I21.A | Other type of myocardial infarction |
I21.A1 | Myocardial infarction type 2 |
I21.A9 | Other myocardial infarction type |
I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
I25.2 | Old myocardial infarction |
Thrombosis prevention after PCI | |
Z98.61 | Coronary angioplasty status |
0-9 | A-Z |
---|---|
I21 | Acute myocardial infarction |
I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
I21.9 | Acute myocardial infarction, unspecified |
I21.A | Other type of myocardial infarction |
I21.A1 | Myocardial infarction type 2 |
I21.A9 | Other myocardial infarction type |
I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
I25.2 | Old myocardial infarction |
Z98.61 | Coronary angioplasty status |