Ethyol

Drug overview for ETHYOL (amifostine crystalline):

Generic name: AMIFOSTINE CRYSTALLINE (A-mi-FOS-teen)
Drug class: Thiol-Type Renal/Tissue Protectants
Therapeutic class: Antineoplastics

No enhanced Introduction information available for this drug.

No enhanced Uses information available for this drug.

DRUG IMAGES

No Image Available

The following indications for ETHYOL (amifostine crystalline) have been approved by the FDA:

Indications:
Prevention of cancer chemotherapy-induced renal impairment
Prevention of xerostomia secondary to radiation therapy

Professional Synonyms:
Impaired renal function due to chemotherapy
Renal function impairment due to chemotherapy
Renal insufficiency due to chemotherapy

The following contraindication information is available for ETHYOL (amifostine crystalline):

Overview
Contraindicated
Severe
Moderate

Drug contraindication overview.

No enhanced Contraindications information available for this drug.

There are 4 contraindications. Absolute contraindication.

Contraindication List
Dehydration
Hypotension
Hypovolemia
Lactation

There are 2 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Hypocalcemia
Vomiting

There are 5 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Cardiac arrhythmia
Cerebrovascular accident
Chronic heart failure
Myocardial ischemia
Transient cerebral ischemia

The following adverse reaction information is available for ETHYOL (amifostine crystalline):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 26 severe adverse reactions.

More Frequent	Less Frequent
Hypotension	None.

Rare/Very Rare
Acute myocardial infarction Acute respiratory failure Anaphylaxis Apnea Atrial fibrillation Atrial flutter Bradycardia Cardiac arrest DRESS syndrome Dyspnea Erythema multiforme Exfoliative dermatitis Extrasystoles Hypertension Hypocalcemia Hypoxia Laryngeal edema Palmar rash Renal failure Seizure disorder Stevens-johnson syndrome Supraventricular tachycardia Tachycardia Toxic epidermal necrolysis Urticaria

Rare/Very Rare

Acute myocardial infarction
Acute respiratory failure
Anaphylaxis
Apnea
Atrial fibrillation
Atrial flutter
Bradycardia
Cardiac arrest
DRESS syndrome
Dyspnea
Erythema multiforme
Exfoliative dermatitis
Extrasystoles
Hypertension
Hypocalcemia
Hypoxia
Laryngeal edema
Palmar rash
Renal failure
Seizure disorder
Stevens-johnson syndrome
Supraventricular tachycardia
Tachycardia
Toxic epidermal necrolysis
Urticaria

There are 18 less severe adverse reactions.

More Frequent	Less Frequent
Nausea Vomiting	None.

Rare/Very Rare
Allergic dermatitis Blurred vision Chest pain Chills Diplopia Dizziness Drowsy Fever Flushing Hiccups Injection site sequelae Malaise Pruritus of skin Skin rash Sneezing Syncope

The following precautions are available for ETHYOL (amifostine crystalline):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

No enhanced Pregnancy information available for this drug.

No enhanced Lactation information available for this drug.

No enhanced Geriatric Use information available for this drug.