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EVZIO (naloxone HCl)
- Opioid overdose
- Opiate-induced respiratory depression
2 mg/0.4 mL injection,auto-injector
- Inject 2 mg by intramuscular route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
Opiate-induced respiratory depression
- Inject 2 mg by subcutaneous route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 2 mg by intramuscular route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 0.4 milliliter (2 mg) by subcutaneous route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 0.4 milliliter (2 mg) by intramuscular route in the outer areaof thigh once, may repeat at 2 to 3 minute intervals as needed
Opioid overdose
- Inject 2 mg by subcutaneous route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 2 mg by intramuscular route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 0.4 milliliter (2 mg) by subcutaneous route in the outer area of thigh once, may repeat at 2 to 3 minute intervals as needed
- Inject 0.4 milliliter (2 mg) by intramuscular route in the outer areaof thigh once, may repeat at 2 to 3 minute intervals as needed
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Opioid dependence
- Opioid withdrawal symptoms
Severe
Moderate
- Cardiac arrhythmia
- Disease of liver
EVZIO (naloxone HCl)
- Opioid overdose
- Opiate-induced respiratory depression
- None
- Dizziness
- Injection site sequelae
More Frequent
Severe
Less Severe
- Hypertension
- Hypotension
- Tachycardia
- Excitement
- Hyperhidrosis
- Irritability
- Nausea
- Nervousness
- Tremor
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cardiac arrest
- Dyspnea
- Hypoxia
- Pulmonary edema
- Seizure disorder
- Ventricular fibrillation
- Ventricular tachycardia
Less Severe
- Agitation
- Flushing
- Hallucinations
- Opioid withdrawal symptoms
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Naloxone
- Severity Level:
B
- Additional Notes: Monitor for fetal withdrawal/distress with parenteral admin in opioid dependence
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Naloxone
Insufficient data available; poor oral absorption
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; poor oral absorption |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Opiate-induced respiratory depression | |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.0x5A | Adverse effect of opium, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.2x5A | Adverse effect of other opioids, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.3x5A | Adverse effect of methadone, initial encounter |
| T40.4x1A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.4x2A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.4x3A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.4x4A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.4x5A | Adverse effect of other synthetic narcotics, initial encounter |
| Opioid overdose | |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.4x1A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.4x2A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.4x3A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.4x4A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
| 0-9 | A-Z |
|---|---|
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x1A | Poisoning by opium, accidental (unintentional), initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x2A | Poisoning by opium, intentional self-harm, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x3A | Poisoning by opium, assault, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.0x4A | Poisoning by opium, undetermined, initial encounter |
| T40.0x5A | Adverse effect of opium, initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x1A | Poisoning by heroin, accidental (unintentional), initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x2A | Poisoning by heroin, intentional self-harm, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x3A | Poisoning by heroin, assault, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.1x4A | Poisoning by heroin, undetermined, initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x1A | Poisoning by other opioids, accidental (unintentional), initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x2A | Poisoning by other opioids, intentional self-harm, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x3A | Poisoning by other opioids, assault, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.2x4A | Poisoning by other opioids, undetermined, initial encounter |
| T40.2x5A | Adverse effect of other opioids, initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x1A | Poisoning by methadone, accidental (unintentional), initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x2A | Poisoning by methadone, intentional self-harm, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x3A | Poisoning by methadone, assault, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.3x4A | Poisoning by methadone, undetermined, initial encounter |
| T40.3x5A | Adverse effect of methadone, initial encounter |
| T40.4x1A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.4x1A | Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter |
| T40.4x2A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.4x2A | Poisoning by other synthetic narcotics, intentional self-harm, initial encounter |
| T40.4x3A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.4x3A | Poisoning by other synthetic narcotics, assault, initial encounter |
| T40.4x4A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.4x4A | Poisoning by other synthetic narcotics, undetermined, initial encounter |
| T40.4x5A | Adverse effect of other synthetic narcotics, initial encounter |
| T40.601A | Poisoning by unspecified narcotics, accidental (unintentional), initial encounter |
| T40.602A | Poisoning by unspecified narcotics, intentional self-harm, initial encounter |
| T40.603A | Poisoning by unspecified narcotics, assault, initial encounter |
| T40.604A | Poisoning by unspecified narcotics, undetermined, initial encounter |
| T40.691A | Poisoning by other narcotics, accidental (unintentional), initial encounter |
| T40.692A | Poisoning by other narcotics, intentional self-harm, initial encounter |
| T40.693A | Poisoning by other narcotics, assault, initial encounter |
| T40.694A | Poisoning by other narcotics, undetermined, initial encounter |
Formulary Reference Tool