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YONDELIS (TRABECTEDIN)
- Leiomyosarcoma
- Liposarcoma
1 mg intravenous solution
- Infuse 1.5 mg/m2 over 24 hour(s) by continuous infusion route every 3Weeks
Leiomyosarcoma
- Infuse 1.5 mg/m2 over 24 hour(s) by continuous infusion route every 3Weeks
- Infuse 1.2 mg/m2 over 24 hour(s) by continuous infusion route every 3Weeks
- Infuse 1 mg/m2 over 24 hour(s) by continuous infusion route every 3 weeks
- Infuse 1 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
- Infuse 1.2 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
- Infuse 1.5 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
Liposarcoma
- Infuse 1.5 mg/m2 over 24 hour(s) by continuous infusion route every 3Weeks
- Infuse 1.2 mg/m2 over 24 hour(s) by continuous infusion route every 3Weeks
- Infuse 1 mg/m2 over 24 hour(s) by continuous infusion route every 3 weeks
- Infuse 1 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
- Infuse 1.2 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
- Infuse 1.5 mg/m2 over 24 hour(s) by intravenous route every 3 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
- Rhabdomyolysis
Contraindicated
- Abnormal hepatic function tests
- Capillary leak syndrome
- Chronic heart failure
- Hyperbilirubinemia
- Myopathy with CK elevation
- Neutropenic disorder
- Pregnancy
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- None
YONDELIS (TRABECTEDIN)
- Leiomyosarcoma
- Liposarcoma
- Abnormal hepatic function tests
- Anemia
- Neutropenic disorder
- Thrombocytopenic disorder
- Anorexia
- Fatigue
- Headache disorder
- Hyperbilirubinemia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Hypokalemia
- Leukopenia
- Pulmonary thromboembolism
- Acute abdominal pain
- Alopecia
- Arthralgias
- Chest pain
- Constipation
- Dehydration
- Diarrhea
- Dizziness
- Dysgeusia
- Dyspepsia
- Dyspnea
- Edema
- Fever
- General weakness
- Injection site sequelae
- Myalgias
- Peripheral edema
- Skin pigmentation enhancement
- Stomatitis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute renal failure
- Bacterial sepsis
- Capillary leak syndrome
- Cardiomyopathy
- Chronic heart failure
- Extravasation injury
- Hepatic failure
- Hepatitis
- Hypersensitivity drug reaction
- Hypotension
- Multiple organ failure
- Pancytopenia
- Rhabdomyolysis
Less Severe
- Flushing
- Hypesthesia
- Insomnia
- Paresthesia
- Peripheral neuropathy
- Tachycardia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Trabectedin
Limited study data for pediatric patients. No safety and efficacy established.
- 1 Day – 18 Years
- Limited study data for pediatric patients. No safety and efficacy established.
Trabectedin
- Severity Level:
D
- Additional Notes: Based on pharmacology, serious adv effects may occur, consider maternal benefit
Contraindicated
Trabedectin
Based on drug pharmacology potential for serious adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Based on drug pharmacology potential for serious adverse effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Formulary Reference Tool