PREZCOBIX (DARUNAVIR ETHANOLATE/COBICISTAT)

Contraindicated



• Advicor
• alfuzosin
• Altoprev
• apixaban
• avanafil
• B cplx-C-St.Johnwrt-K.&S.ginsg
• Belladonna-phenobarbital
• Brilinta
• bromocriptine
• cabergoline
• Cafergot
• calcium-mag-B complex-D3-hrb61
• Camptosar
• carbamazepine
• Carbatrol
• Cerebyx
• Cold & Flu Fighter
• conivaptan in 5 % dextrose
• Cycloset
• D.h.e.45
• Detrol La
• dextromethorphan-quinidine
• dihydroergotamine
• Dilantin
• Dilantin Extended
• Dilantin Infatabs
• Dilantin Kapseal
• Dilantin-125
• Donnatal
• dronedarone
• dutasteride-tamsulosin
• eletriptan HBr
• Eliquis
• elvitegr-cobicist-emtric-tenof
• enzalutamide
• Epitol
• eplerenone
• Equetro
• ergoloid
• Ergomar
• ergotamine tartrate
• ergotamine-caffeine
• ezetimibe-simvastatin
• Fatigue Relief Complex
• Flomax
• fosphenytoin
• Inspra
• irinotecan
• isoniazid-rifamp-pyrazinamide
• Jalyn
• Juxtapid
• Kombiglyze Xr
• Latuda
• Levitra
• lomitapide
• lovastatin
• Luminal
• lurasidone
• methylergonovine
• Mevacor
• midazolam
• Migergot
• Migranal
• Multaq
• Mysoline
• nevirapine
• niacin-lovastatin
• niacin-simvastatin
• Nuedexta
• Orap
• Parlodel
• phenobarb-hyoscy-atropine-scop
• phenobarbital
• phenobarbital sodium
• Phenytek
• phenytoin
• phenytoin sodium
• phenytoin sodium extended
• pimozide
• primidone
• quinidine gluconate
• quinidine sulfate
• Rapaflo
• Relpax
• Revatio
• Rifadin
• Rifamate
• rifampin
• rifampin-isoniazid
• Rifater
• rivaroxaban
• Samsca
• saxagliptin-metformin
• sildenafil
• silodosin
• Simcor
• simvastatin
• St. John's wort
• Stendra
• Stribild
• tamsulosin
• Tegretol
• Tegretol Xr
• ticagrelor
• tolterodine
• tolvaptan
• triazolam
• Uroxatral
• Vaprisol
• vardenafil
• Viramune
• Viramune Xr
• vit C-St. John wort-elder-hb30
• Vytorin 10-10
• Vytorin 10-20
• Vytorin 10-40
• Vytorin 10-80
• Women's Complex
• Xarelto
• Xtandi
• Zocor

Severe



• A-methapred
• Abstral
• Actiq
• Advair Diskus
• Advair Hfa
• Afinitor
• Afinitor Disperz
• Alfenta
• alfentanil
• Altavera (28)
• Alyacen 1/35 (28)
• Alyacen 7/7/7 (28)
• Amethia
• Amethia Lo
• Amethyst
• Apri
• Aranelle (28)
• Aristospan Intra-articular
• Aristospan Intralesional
• Astagraf Xl
• Aubra
• Aviane
• azelastine-fluticasone
• Azurette (28)
• B6-FA-B12-co Q10-herb no.225
• Balziva (28)
• Beauty & Skin Therapy
• Beyaz
• bosentan
• Breo Ellipta
• Brevicon (28)
• Briellyn
• budesonide
• budesonide-formoterol
• Camila
• Camrese
• Camrese Lo
• Caziant (28)
• Chateal
• colchicine
• colchicine-probenecid
• Colcrys
• Cryselle (28)
• Cyclafem 1/35 (28)
• Cyclafem 7/7/7 (28)
• Cyclessa (28)
• cyclosporine
• cyclosporine modified
• Dasetta 1/35 (28)
• Dasetta 7/7/7 (28)
• Daysee
• Depo-medrol
• Depo-provera
• Depo-subq Provera 104
• desog-e.estradiol/e.estradiol
• Desogen
• desogestrel-ethinyl estradiol
• dexamethasone
• Dexamethasone Intensol
• dexamethasone sodium phos (PF)
• dexamethasone sodium phosphate
• Dexpak 10 Day
• Dexpak 13 Day
• Dexpak 6 Day
• drospirenone-e.estradiol-lm.FA
• drospirenone-ethinyl estradiol
• Duragesic
• Dymista
• Elinest
• Emoquette
• Endocet
• Endodan
• Enpresse
• Enskyce
• Entocort Ec
• Errin
• Estarylla
• estradiol valerate-dienogest
• Estrostep Fe-28
• ethynodiol diac-eth estradiol
• etonogestrel
• etonogestrel-ethinyl estradiol
• everolimus
• Ez Use Joint-tunnel-trigger
• Falmina (28)
• Femcon Fe
• fentanyl
• fentanyl citrate
• fentanyl citrate (PF)
• Fentora
• Flo-pred
• Flonase
• Flovent Diskus
• Flovent Hfa
• fluticasone
• fluticasone furoate
• fluticasone-salmeterol
• fluticasone-vilanterol
• Fortavit
• Generess Fe
• Gengraf
• Gianvi (28)
• Gildagia
• Gildess
• Gildess Fe
• guanfacine
• Healthy Heart Complex
• Heather
• Hecoria
• Hycamtin
• ibuprofen-oxycodone
• Incivek
• Introvale
• Intuniv Er
• Invirase
• Jencycla
• Jolessa
• Jolivette
• Junel 1.5/30 (21)
• Junel 1/20 (21)
• Junel Fe 1.5/30 (28)
• Junel Fe 1/20 (28)
• Kaletra
• Kariva (28)
• Kelnor 1/35 (28)
• Kenalog
• Korlym
• Kurvelo
• L norgest&E estradiol-E estrad
• Larin 1/20 (21)
• Larin Fe
• Lazanda
• Leena 28
• Lessina
• Levonest (28)
• levonorg-eth estrad triphasic
• levonorgestrel
• levonorgestrel-ethinyl estrad
• Levora 0.15/30 (28)
• Levora-28
• Lo Loestrin Fe
• Loestrin 1.5/30 (21)
• Loestrin 1/20 (21)
• Loestrin Fe 1.5/30 (28)
• Loestrin Fe 1/20 (28)
• Lomedia 24 Fe
• lopinavir-ritonavir
• Loryna (28)
• Loseasonique
• Low-ogestrel (28)
• Lutera (28)
• Lyza
• macitentan
• Marlissa
• Maximum Daily Green
• Medrol
• Medrol (pak)
• medroxyprogesterone
• Megavite
• Megavite Golden Years 55+
• methylprednisolone
• methylprednisolone acetate
• methylprednisolone sod suc(PF)
• methylprednisolone sodium succ
• methylprednisolone-bupivacaine
• Microgestin 1.5/30 (21)
• Microgestin 1/20 (21)
• Microgestin Fe 1.5/30 (28)
• Microgestin Fe 1/20 (28)
• mifepristone
• Millipred
• Millipred Dp
• Minastrin 24 Fe
• Mircette (28)
• Mirena
• Modicon (28)
• Mono-linyah
• Mononessa (28)
• MSM-collag-co Q10-herb no.226
• multivit-Fe-min-DNA-RNA-dsup4
• mv-iron-FA-Ca-beepoln-hb 101
• mv-mn-FA-herbs190&215-digest#4
• mv-mn-FA-lycopene-lut-#178herb
• mv-mn-iron-FA-herbal cmplx#190
• My Way
• Mycobutin
• Myzilra
• Nasacort
• Nasacort Aq
• Natazia
• Necon 0.5/35 (28)
• Necon 1/35 (28)
• Necon 1/50 (28)
• Necon 10/11 (28)
• Necon 7/7/7 (28)
• Neoral
• Nexplanon
• Next Choice One Dose
• Nor-qd
• Nora-be
• norelgestrom-ethinyl estradiol
• noreth-ethinyl estradiol-iron
• norethin-e.estradiol triphasic
• norethin-eth estrad biphasic
• norethindrone (contraceptive)
• norethindrone ac-eth estradiol
• norethindrone-e.estradiol-iron
• norethindrone-ethin estradiol
• norethindrone-mestranol
• norgestimate-ethinyl estradiol
• norgestrel-ethinyl estradiol
• Norinyl 1+35 (28)
• Norinyl 1+50 (28)
• Nortrel 0.5/35 (28)
• Nortrel 1/35 (21)
• Nortrel 1/35 (28)
• Nortrel 7/7/7 (28)
• Nuvaring
• Ocella
• Ogestrel (28)
• Oleptro Er
• Olysio
• Opsumit
• Orapred
• Orapred Odt
• Orsythia
• Ortho Evra
• Ortho Micronor
• Ortho Tri-cyclen (28)
• Ortho Tri-cyclen Lo (28)
• Ortho-cept (28)
• Ortho-cyclen (28)
• Ortho-novum 1/35 (28)
• Ortho-novum 7/7/7 (28)
• Ovcon-35 (28)
• Oxecta
• oxycodone
• oxycodone-acetaminophen
• oxycodone-aspirin
• Oxycontin
• Pediapred
• Percocet
• Percodan
• Philith
• Physicians Ez Use M-pred
• Pimtrea (28)
• Pirmella
• Plan B One-step
• policosan-inositol niac-garlic
• Policosanol-garlic-niacin
• Portia
• prednisolone
• prednisolone acetate
• prednisolone sodium phosphate
• prednisone
• Prednisone Intensol
• Previfem
• Priftin
• Primlev
• Prograf
• Pulmicort
• Pulmicort Flexhaler
• Quartette
• Quasense
• Rapamune
• Rayos
• Reclipsen (28)
• Rhinocort Aqua
• rifabutin
• rifapentine
• Roxicet
• Safyral
• salmeterol
• Sandimmune
• saquinavir mesylate
• Seasonique
• Serevent Diskus
• simeprevir
• sirolimus
• Skyla
• Solu-medrol
• Solu-medrol (pf)
• Sprintec (28)
• Sronyx
• Sublimaze (pf)
• Subsys
• Syeda
• Symbicort
• tacrolimus
• telaprevir
• temsirolimus
• Tenex
• Tilia Fe
• topotecan
• Torisel
• Tracleer
• trazodone
• Tri-estarylla
• Tri-legest Fe
• Tri-linyah
• Tri-norinyl (28)
• Tri-previfem (28)
• Tri-sprintec (28)
• triamcinolone acetonide
• triamcinolone hexacetonide
• triamcinolone-lidocaine
• Trinessa (28)
• Trivora (28)
• Uceris
• Velivet Triphasic Regimen (28)
• Veramyst
• Veripred 20
• Vestura (28)
• Vfend
• Vfend Iv
• Viorele (28)
• voriconazole
• Vyfemla (28)
• Wera (28)
• Wymzya Fe
• Xartemis Xr
• Yasmin (28)
• Yaz 28
• Zarah
• Zenchent (28)
• Zenchent Fe
• Zeosa
• Zortress
• Zovia 1/35E (28)
• Zovia 1/50E (28)

Contraindicated



• Lactating mother
• Pregnancy

Severe



• Disease of liver

Contraindicated

None

Severe Precaution

Darunavir

Potential increased risk for toxicity based on observed juvenile animal toxicity and mortality. Not recommended per manufacturer.

• 1 Day – 3 Years
• Potential increased risk for toxicity based on observed juvenile animal toxicity and mortality. Not recommended per manufacturer.

Management or Monitoring Precaution

Darunavir, Cobicistat

No safety data available age < 18 years. Darunavir not recommended age < 3 years.

• 3 Years – 18 Years
• No safety data available age < 18 years. Darunavir not recommended age < 3 years.