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SPORANOX (ITRACONAZOLE)
- Aspergillosis
- Blastomycosis
- Esophageal candidiasis
- Fingernail onychomycosis
- Histoplasmosis
- Oropharyngeal candidiasis
- Toenail onychomycosis
- Sporanox Pulsepak Capsule
- Sporanox Oral Solution
- Sporanox Oral Soln
- Sporanox Capsule
- Itraconazole Oral Solution
- Itraconazole Capsule
- By Indication
Pulsepak 100 mg capsule
- 2 capsules (200 mg) by oral route once daily with food
10 mg/mL oral solution
- 10 milliliters (100 mg) and swish and swallow by oral route oncedaily
10 mg/mL oral solution
- 10 milliliters (100 mg) and swish and swallow by oral route oncedaily
100 mg capsule
- 2 capsules (200 mg) by oral route once daily with food
10 mg/mL oral solution
- 10 milliliters (100 mg) and swish and swallow by oral route oncedaily
100 mg capsule
- 2 capsules (200 mg) by oral route once daily with food
Aspergillosis
- 2 capsules (200 mg) by oral route once daily with food for 90 days
- 2 capsules (200 mg) by oral route 2 times per day with food for 90 days
- 2 capsules (200 mg) by oral route once daily with food
- 2 capsules (200 mg) by oral route 2 times per day with food
Blastomycosis
- 2 capsules (200 mg) by oral route once daily with food
- 2 capsules (200 mg) by oral route 2 times per day with food
Coccidioidomycosis
- 2 capsules (200 mg) by oral route 2 times per day with food for 42 days
- 2 capsules (200 mg) by oral route 2 times per day with food
Esophageal candidiasis
- 1 capsule (100 mg) by oral route once daily with food
- 10 milliliters (100 mg) and swish and swallow by oral route oncedaily for 21 days
- 10 milliliters (100 mg) and swish and swallow by oral route oncedaily
- 1 capsule (100 mg) by oral route once daily with food for 14 days
- 2 capsules (200 mg) by oral route once daily with food for 14 days
- 2 capsules (200 mg) by oral route once daily with food
Febrile neutropenic patient presumed infection treatment
- 20 milliliters (200 mg) by oral route 2 times per day for 28 days
- 20 milliliters (200 mg) by oral route 2 times per day
Fingernail onychomycosis
- 2 capsules (200 mg) by oral route 2 times per day with food for 1 week ; no medicine during weeks 2-4; repeat treatment on week 5
Histoplasmosis
- 2 capsules (200 mg) by oral route once daily with food
- 2 capsules (200 mg) by oral route 2 times per day with food
Oropharyngeal candidiasis
- 20 milliliters (200 mg) and swish and swallow by oral route oncedaily for 7 days
- 20 milliliters (200 mg) and swish and swallow by oral route oncedaily for 14 days
- 20 milliliters (200 mg) and swish and swallow by oral route oncedaily
Toenail onychomycosis
- 2 capsules (200 mg) by oral route once daily with food for 12 weeks
- 2 capsules (200 mg) by oral route once daily with food
- Advicor
- alfuzosin
- alprazolam
- Alprazolam Intensol
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- apixaban
- avanafil
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- Camptosar
- conivaptan in 5 % dextrose
- Cordarone
- Cycloset
- D.h.e.45
- Detrol La
- dextromethorphan-quinidine
- dihydroergotamine
- Diskets
- dofetilide
- Dolophine
- dronedarone
- dutasteride-tamsulosin
- eletriptan HBr
- Eliquis
- eplerenone
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- estazolam
- ezetimibe-simvastatin
- felodipine
- Flomax
- Inspra
- irinotecan
- isoniazid
- isoniazid-rifamp-pyrazinamide
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- lomitapide
- lovastatin
- lurasidone
- methadone
- Methadone Intensol
- Methadose
- methylergonovine
- Mevacor
- midazolam
- Migergot
- Migranal
- Multaq
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Niravam
- nisoldipine
- Nuedexta
- Orap
- Pacerone
- Parlodel
- pimozide
- quinidine gluconate
- quinidine sulfate
- Rapaflo
- Relpax
- Rifamate
- rifampin-isoniazid
- Rifater
- rivaroxaban
- Samsca
- saxagliptin-metformin
- silodosin
- Simcor
- simvastatin
- Stendra
- Sular
- tamsulosin
- ticagrelor
- Tikosyn
- tolterodine
- tolvaptan
- triazolam
- Uroxatral
- Vaprisol
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Xanax
- Xanax Xr
- Xarelto
- Zocor
Contraindicated
- Abstral
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- Actiq
- Adempas
- Advair Diskus
- Advair Hfa
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- amoxicil-clarithromy-lansopraz
- Amturnide
- Astagraf Xl
- Atripla
- carbamazepine
- Carbatrol
- Cerebyx
- cimetidine
- colchicine
- colchicine-probenecid
- Colcrys
- Complete
- Coumadin
- cyclosporine
- cyclosporine modified
- Deprizine
- Dexilant
- dexlansoprazole
- Digox
- digoxin
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Dual Action Complete
- Duexis
- Duragesic
- efavirenz
- efavirenz-emtricitabin-tenofov
- Endocet
- Endodan
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- ethotoin
- everolimus
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- First-lansoprazole
- First-omeprazole
- fluticasone-salmeterol
- fosphenytoin
- Gengraf
- guanfacine
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- Hecoria
- Hycamtin
- ibuprofen-famotidine
- ibuprofen-oxycodone
- Intuniv Er
- Jantoven
- Korlym
- Lanoxin
- Lanoxin Pediatric
- lansoprazole
- Lazanda
- macitentan
- Marqibo
- mifepristone
- naproxen-esomeprazole
- Navelbine
- Neoral
- nevirapine
- Nexium
- Nexium Iv
- Nexium Packet
- nizatidine
- Oleptro Er
- Olysio
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- Opsumit
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- pantoprazole
- Peganone
- Pepcid
- Pepcid Ac
- Pepcid Complete
- Percocet
- Percodan
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prilosec
- Prilosec Otc
- Primlev
- Prograf
- Protonix
- quetiapine
- rabeprazole
- ranitidine HCl
- Rapamune
- riociguat
- Roxicet
- salmeterol
- Sandimmune
- Serevent Diskus
- Seroquel
- Seroquel Xr
- simeprevir
- sirolimus
- Sublimaze (pf)
- Subsys
- Sustiva
- tacrolimus
- Tagamet Hb
- Tegretol
- Tegretol Xr
- Tekamlo
- Tekturna
- Tekturna Hct
- temsirolimus
- Tenex
- topotecan
- Torisel
- trazodone
- Tums Dual Action
- Vimovo
- vinblastine
- Vincasar Pfs
- vincristine
- vincristine sulfate liposomal
- vinorelbine
- Viramune
- Viramune Xr
- Wal-zan 150
- warfarin
- Xartemis Xr
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
- Zortress
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adalat Cc
- Adcirca
- afatinib
- Afeditab Cr
- almotriptan malate
- Alvesco
- Amaryl
- Ambien
- Ambien Cr
- amlodipine
- amlodipine-atorvastatin
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Anaspaz
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anucort-hc
- Anusol-hc
- Aptivus
- aripiprazole
- artemether-lumefantrine
- Asmanex Twisthaler
- atorvastatin
- Axert
- azelastine-fluticasone
- Azor
- Belladonna-phenobarbital
- boceprevir
- bosentan
- Breo Ellipta
- budesonide
- budesonide-formoterol
- busulfan
- Caduet
- Calan
- Calan Sr
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cialis
- ciclesonide
- cilostazol
- Coartem
- Colocort
- Cortef
- Cortenema
- Cortifoam
- Crixivan
- darifenacin
- darunavir
- Depo-medrol
- Detrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diabeta
- Diamode
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Donnatal
- Duetact
- Dulera
- Dymista
- Ed-spaz
- Edluar
- elvitegr-cobicist-emtric-tenof
- Enablex
- Entocort Ec
- erlotinib
- eszopiclone
- Etopophos
- etoposide
- etoposide phosphate
- Exforge
- Exforge Hct
- ezetimibe-atorvastatin
- fesoterodine
- Fetzima
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fludrocortisone
- fluticasone
- fluticasone furoate
- fluticasone-vilanterol
- fosamprenavir
- Gilotrif
- Gleevec
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Grx Hicort 25
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- imatinib
- Imodium Multi-symptom Relief
- Incivek
- indinavir
- Intermezzo
- Istodax
- ivacaftor
- Kaletra
- Kalydeco
- Ketek
- Levbid
- Levitra
- levomilnacipran
- Levsin
- Levsin/sl
- Lexiva
- Lipitor
- Liptruzet
- Lo-peramide
- loperamide
- loperamide-simethicone
- lopinavir-ritonavir
- Lotrel
- Lunesta
- Matzim La
- Medrol
- Medrol (pak)
- mefloquine
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- midazolam (PF)
- Millipred
- Millipred Dp
- mometasone
- mometasone-formoterol
- mth-me blue-sod phos-phsal-hyo
- Mycobutin
- Myleran
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- Norvasc
- Norvir
- Norvir Soft Gelatin
- Nulev
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- olmesartan-amlodipin-hcthiazid
- Omnaris
- Onglyza
- Orapred
- Orapred Odt
- Oscimin
- Oscimin Sl
- Oscimin Sr
- Pediapred
- phenobarb-hyoscy-atropine-scop
- Phosphasal
- Physicians Ez Use M-pred
- pioglitazone-glimepiride
- Pletal
- pomalidomide
- Pomalyst
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prezista
- Priftin
- Procardia
- Procardia Xl
- Proctocort
- Prosed/ds (atropine Free)
- Pulmicort
- Pulmicort Flexhaler
- Rayos
- Rectacort-hc
- regorafenib
- Revatio
- Rhinocort Aqua
- rifabutin
- Rifadin
- rifampin
- rifapentine
- ritonavir
- romidepsin
- saxagliptin
- sildenafil
- solifenacin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Stivarga
- Stribild
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Symbicort
- tadalafil
- Tarceva
- Tarka
- Taztia Xt
- telaprevir
- telithromycin
- telmisartan-amlodipine
- Tiazac
- tipranavir
- tolazamide
- tolbutamide
- Toposar
- Toviaz
- Tracleer
- trandolapril-verapamil
- Tribenzor
- Twynsta
- Uceris
- Ultra A-d
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Valium
- vardenafil
- Veramyst
- verapamil
- Verelan
- Verelan Pm
- Veripred 20
- Vesicare
- Viagra
- Victrelis
- Zetonna
- zolpidem
- Zolpimist
- None
Contraindicated
- Abnormal hepatic function tests
- Chronic heart failure
Severe
Moderate
- Achlorhydria
- Chronic obstructive pulmonary disease
- Edema
- Hearing loss
- Hypochlorhydria
- Kidney disease with reduction in GFR
- Myocardial ischemia
- Peripheral neuropathy
- Valvular heart disease
SPORANOX (ITRACONAZOLE)
- Aspergillosis
- Blastomycosis
- Esophageal candidiasis
- Fingernail onychomycosis
- Histoplasmosis
- Oropharyngeal candidiasis
- Toenail onychomycosis
- Upper respiratory infection
- Headache disorder
- Nausea
- Rhinitis
- Sinusitis
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Aphthous stomatitis
- Disease of liver
- Drug fever
- Edema
- Herpes zoster
- Hypertension
- Hypokalemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Proteinuria
- Acute abdominal pain
- Allergic dermatitis
- Anorexia
- Constipation
- Cystitis
- Depression
- Diarrhea
- Disorder of the digestive system
- Dizziness
- Drowsy
- Dyspepsia
- Erectile dysfunction
- Fatigue
- Flatulence
- Gastritis
- Gastroenteritis
- General weakness
- Gynecomastia
- Hypertriglyceridemia
- Insomnia
- Libido changes
- Malaise
- Mastalgia
- Menstrual disorder
- Myalgias
- Orthostatic hypotension
- Pain
- Pharyngitis
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Tinnitus
- Tremor
- Urinary tract infection
- Vasculitis
- Vertigo
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Anaphylaxis
- Angioedema
- Cardiac arrhythmia
- Chronic heart failure
- Erythema multiforme
- Exfoliative dermatitis
- Hearing loss
- Hepatic failure
- Hepatitis
- Hyperbilirubinemia
- Hyperkalemia
- Hypersensitivity angiitis
- Hypomagnesemia
- Jaundice
- Kidney disease with reduction in GFR
- Left ventricular failure
- Leukopenia
- Neutropenic disorder
- Pancreatitis
- Peripheral edema
- Pulmonary edema
- Serum sickness
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
Less Severe
- Acute confusion
- Alopecia
- Arthralgias
- Bursitis
- Chest pain
- Chills
- Cough
- Dream disorder
- Dysgeusia
- Dyspnea
- Erythema
- Facial edema
- Gingivitis
- Hyperglycemia
- Hyperhidrosis
- Hypesthesia
- Hypotension
- Paresthesia
- Peripheral neuropathy
- Skin photosensitivity
- Tachycardia
- Urinary incontinence
- Urticaria
- Visual changes
- Voice change
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Itraconazole
Unknown long term effects on bone growth and tooth development. No safety and efficacy.
- 1 Day – 18 Years
- Unknown long term effects on bone growth and tooth development. No safety and efficacy.
Itraconazole
- Severity Level:
2
- Additional Notes: Not rec for onychomycosis tx; risk of spontaneous abortion
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Itraconazole
Potential for accumulation in infant; effects unknown.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Potential for accumulation in infant; effects unknown. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Itraconazole
Neuro/Psych-Transient or permanent hearing loss has been reported in elderly patients. Monitor for hearing changes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Itraconazole should not be used to treat fungal nail infections if you have a history of heart failure. Itraconazole may rarely cause or worsen heart failure. Tell your doctor right away if you develop symptoms of heart failure, such as shortness of breath, swelling ankles/feet, unusual tiredness, or unusual/sudden unexplained weight gain.<br /><br />Consult your doctor for more details. This medication can slow down the removal of other medications from your body, which may cause very serious (possibly fatal) side effects to occur. Examples of affected drugs include certain "blood thinners" (such as ticagrelor), colchicine, certain drugs to treat irregular heartbeat (such disopyramide, dofetilide, dronedarone, quinidine), eplerenone, ergot alkaloids (such as dihydroergotamine, ergotamine, methylergonovine), felodipine, fesoterodine, irinotecan, ivabradine, lurasidone, methadone, midazolam, nisoldipine, pimozide, ranolazine, certain "statin" cholesterol drugs (such as lovastatin, simvastatin), solifenacin, telithromycin, triazolam, among others. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
| Aspergillosis | |
| B44 | Aspergillosis |
| B44.0 | Invasive pulmonary aspergillosis |
| B44.1 | Other pulmonary aspergillosis |
| B44.2 | Tonsillar aspergillosis |
| B44.7 | Disseminated aspergillosis |
| B44.8 | Other forms of aspergillosis |
| B44.81 | Allergic bronchopulmonary aspergillosis |
| B44.89 | Other forms of aspergillosis |
| B44.9 | Aspergillosis, unspecified |
| Blastomycosis | |
| B40 | Blastomycosis |
| B40.0 | Acute pulmonary blastomycosis |
| B40.1 | Chronic pulmonary blastomycosis |
| B40.2 | Pulmonary blastomycosis, unspecified |
| B40.3 | Cutaneous blastomycosis |
| B40.7 | Disseminated blastomycosis |
| B40.8 | Other forms of blastomycosis |
| B40.81 | Blastomycotic meningoencephalitis |
| B40.89 | Other forms of blastomycosis |
| B40.9 | Blastomycosis, unspecified |
| Esophageal candidiasis | |
| B37.81 | Candidal esophagitis |
| Fingernail onychomycosis | |
| B35.1 | Tinea unguium |
| Histoplasmosis | |
| B39 | Histoplasmosis |
| B39.0 | Acute pulmonary histoplasmosis capsulati |
| B39.1 | Chronic pulmonary histoplasmosis capsulati |
| B39.2 | Pulmonary histoplasmosis capsulati, unspecified |
| B39.3 | Disseminated histoplasmosis capsulati |
| B39.4 | Histoplasmosis capsulati, unspecified |
| B39.5 | Histoplasmosis duboisii |
| B39.9 | Histoplasmosis, unspecified |
| Oropharyngeal candidiasis | |
| B37.0 | Candidal stomatitis |
| Toenail onychomycosis | |
| B35.1 | Tinea unguium |
| 0-9 | A-Z |
|---|---|
| B35.1 | Tinea unguium |
| B35.1 | Tinea unguium |
| B37.0 | Candidal stomatitis |
| B37.81 | Candidal esophagitis |
| B39 | Histoplasmosis |
| B39.0 | Acute pulmonary histoplasmosis capsulati |
| B39.1 | Chronic pulmonary histoplasmosis capsulati |
| B39.2 | Pulmonary histoplasmosis capsulati, unspecified |
| B39.3 | Disseminated histoplasmosis capsulati |
| B39.4 | Histoplasmosis capsulati, unspecified |
| B39.5 | Histoplasmosis duboisii |
| B39.9 | Histoplasmosis, unspecified |
| B40 | Blastomycosis |
| B40.0 | Acute pulmonary blastomycosis |
| B40.1 | Chronic pulmonary blastomycosis |
| B40.2 | Pulmonary blastomycosis, unspecified |
| B40.3 | Cutaneous blastomycosis |
| B40.7 | Disseminated blastomycosis |
| B40.8 | Other forms of blastomycosis |
| B40.81 | Blastomycotic meningoencephalitis |
| B40.89 | Other forms of blastomycosis |
| B40.9 | Blastomycosis, unspecified |
| B44 | Aspergillosis |
| B44.0 | Invasive pulmonary aspergillosis |
| B44.1 | Other pulmonary aspergillosis |
| B44.2 | Tonsillar aspergillosis |
| B44.7 | Disseminated aspergillosis |
| B44.8 | Other forms of aspergillosis |
| B44.81 | Allergic bronchopulmonary aspergillosis |
| B44.89 | Other forms of aspergillosis |
| B44.9 | Aspergillosis, unspecified |
Formulary Reference Tool