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RISPERDAL (RISPERIDONE)
- Schizophrenia
- Infantile autism
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Risperidone Tablet
- Risperidone Oral Solution
- Risperidone Oral Soln
- Risperdal Tablet
- Risperdal Oral Solution
- By Indication
0.25 mg tablet
- 2 tablets (0.5 mg) by oral route 2 times per day
0.5 mg tablet
- 2 tablets (1 mg) by oral route 2 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 2 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 2 times per day
3 mg tablet
- 1 tablet (3 mg) by oral route 2 times per day
4 mg tablet
- 1 tablet (4 mg) by oral route 2 times per day
1 mg/mL oral solution
- 2 milliliters (2 mg) by oral route 2 times per day
1 mg/mL oral solution
- 2 milliliters (2 mg) by oral route 2 times per day
0.5 mg tablet
- 2 tablets (1 mg) by oral route 2 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route 2 times per day
2 mg tablet
- 1 tablet (2 mg) by oral route 2 times per day
3 mg tablet
- 1 tablet (3 mg) by oral route 2 times per day
4 mg tablet
- 1 tablet (4 mg) by oral route 2 times per day
1 mg/mL oral solution
- 2 milliliters (2 mg) by oral route 2 times per day
Mania associated with bipolar disorder
- 1 tablet (1 mg) by oral route once daily
- 2 tablets (1 mg) by oral route once daily
- 1 milliliter (1 mg) by oral route once daily
- 2 milliliters (2 mg) by oral route once daily
- 2 tablets (2 mg) by oral route once daily
- 1 tablet (2 mg) by oral route once daily
- 1 tablet (3 mg) by oral route once daily
- 2 tablets (4 mg) by oral route once daily
- 1 tablet (4 mg) by oral route once daily
- 3 tablets (6 mg) by oral route once daily
- 2 tablets (6 mg) by oral route once daily
Schizophrenia
- 1 tablet (1 mg) by oral route 2 times per day
- 2 tablets (1 mg) by oral route 2 times per day
- 2 milliliters (2 mg) by oral route 2 times per day
- 2 tablets (2 mg) by oral route 2 times per day
- 1 tablet (2 mg) by oral route 2 times per day
- 3 milliliters (3 mg) by oral route 2 times per day
- 1 tablet (3 mg) by oral route 2 times per day
- 4 milliliters (4 mg) by oral route 2 times per day
- 4 milliliters (4 mg) by oral route once daily
- 1 tablet (4 mg) by oral route 2 times per day
- 2 tablets (4 mg) by oral route 2 times per day
- 5 milliliters (5 mg) by oral route 2 times per day
- 5 milliliters (5 mg) by oral route once daily
- 2 tablets (6 mg) by oral route 2 times per day
- 6 milliliters (6 mg) by oral route once daily
- 6 milliliters (6 mg) by oral route 2 times per day
- 7 milliliters (7 mg) by oral route 2 times per day
- 7 milliliters (7 mg) by oral route once daily
- 8 milliliters (8 mg) by oral route once daily
- 8 milliliters (8 mg) by oral route 2 times per day
- 2 tablets (8 mg) by oral route 2 times per day
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- cabergoline
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Aplenzin
- Apokyn
- apomorphine
- Ascomp With Codeine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Brisdelle
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cerebyx
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Comtan
- Cymbalta
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- duloxetine
- entacapone
- enzalutamide
- Epitol
- Equetro
- Esgic
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluoxetine
- Forfivo Xl
- fosphenytoin
- isoniazid-rifamp-pyrazinamide
- Luminal
- Lysodren
- Margesic
- Marten-tab
- Mirapex
- Mirapex Er
- mitotane
- Mycobutin
- Mysoline
- Nembutal Sodium
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- pentobarbital sodium
- Pexeva
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pramipexole
- primidone
- Prozac
- Prozac Weekly
- Requip
- Requip Xl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ropinirole
- Sarafem
- secobarbital sodium
- Seconal Sodium
- Sinemet
- Sinemet Cr
- St. John's wort
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Symbyax
- Tegretol
- Tegretol Xr
- Tencon
- vit C-St. John wort-elder-hb30
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Women's Complex
- Xtandi
- Zebutal
- Zyban
- Agranulocytosis
- Congenital long QT syndrome
- Neuroleptic malignant syndrome
Contraindicated
- Acute myocardial infarction
- Atherosclerotic cardiovascular disease
- Cardiac arrhythmia
- Cataract surgery
- Cerebrovascular accident
- Cerebrovascular disorder
- Chronic heart failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Dehydration
- Diffuse lewy body disease
- Disease of liver
- Hypotension
- Hypovolemia
- Leukopenia
- Myocardial ischemia
- Neutropenic disorder
- Orthostatic hypotension
- Parkinsonism
- Rhabdomyolysis
- Senile dementia
- Severe hepatic disease
- Tardive dyskinesia
Severe
Moderate
- Acute confusion
- Carcinoma of breast
- Diabetes mellitus
- Drug abuse
- Dysphagia
- Fever
- Hyperlipidemia
- Hyperprolactinemia
- Hypothermia
- Intraoperative floppy iris syndrome
- Metabolic syndrome X
- Obesity
- Predisposition to aspiration
- Priapism
- Seizure disorder
- Urinary retention
- Weight gain
RISPERDAL (RISPERIDONE)
- Schizophrenia
- Infantile autism
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Akathisia
- Dyskinesia
- Extrapyramidal disease
- Parkinsonism
- Visual changes
- Abnormal sexual function
- Acquired dystonia
- Agitation
- Altered mental status
- Appetite changes
- Blurred vision
- Constipation
- Cough
- Diarrhea
- Dizziness
- Drowsy
- Dyspepsia
- Fatigue
- Headache disorder
- Increased appetite
- Injection site sequelae
- Insomnia
- Libido changes
- Nasal congestion
- Nausea
- Nervousness
- Pharyngitis
- Pruritus of skin
- Rhinitis
- Rhinorrhea
- Sedation
- Sialorrhea
- Skin rash
- Sore throat
- Symptoms of anxiety
- Tremor
- Upper respiratory infection
- Urinary incontinence
- Vomiting
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypotension
- Orthostatic hypotension
- Abdominal pain with cramps
- Acute confusion
- Arthralgias
- Ataxia
- Back pain
- Concentration difficulty
- Dyspnea
- Epistaxis
- Galactorrhea not associated with childbirth
- General weakness
- Hypercholesterolemia
- Hyperprolactinemia
- Hypertriglyceridemia
- Menstrual disorder
- Muscle weakness
- Myalgias
- Palpitations
- Seborrhea
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Accidental fall
- Agranulocytosis
- Altered consciousness
- Anaphylaxis
- Anemia
- Angioedema
- Aspiration pneumonia
- Atrial fibrillation
- Atrioventricular block
- Bradycardia
- Cerebral ischemia
- Cerebrovascular accident
- Diabetes mellitus
- DRESS syndrome
- Esophageal dysmotility
- Fever
- Gastrointestinal obstruction
- Heart block
- Hypertension
- Hypothermia
- Ileus
- Influenza
- Intraoperative floppy iris syndrome
- Jaundice
- Leukopenia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Pancreatitis
- Pituitary neoplasm
- Pneumonia
- Priapism
- Pulmonary thromboembolism
- Rhabdomyolysis
- Seizure disorder
- SIADH syndrome
- Sinus tachycardia
- Sleep apnea
- Tardive dyskinesia
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Tongue swelling
- Transient cerebral ischemia
- Water intoxication
Less Severe
- Alopecia
- Amenorrhea
- Anorexia
- Blepharospasm
- Cheilitis
- Complex sleep behavior
- Conjunctival hyperemia
- Disorder of ejaculation
- Disturbance of attention
- Dysarthria
- Dysgeusia
- Dysphagia
- Earache
- Edema
- Eyelid edema
- Fecal incontinence
- Flatulence
- Gastritis
- Gynecomastia
- Hypesthesia
- Hypoglycemic disorder
- Infection of ear
- Joint stiffness
- Lip swelling
- Mastalgia
- Muscle spasm
- Musculoskeletal pain
- Non-cardiac chest pain
- Ocular crusting
- Peripheral edema
- Photophobia
- Reduced visual acuity
- Retrograde ejaculation
- Sleep disorder
- Sleep walking disorder
- Syncope
- Tinnitus
- Urinary retention
- Urinary tract infection
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Risperidone (oral)
Safety and efficacy not established age < 5 years. Unknown effects on growth, development. Risk of weight gain, cardiometabolic abnormalities.
Rare risk of tardive dyskinesia, risk of hyperglycemia, weight gain, hyperlipidemia, hyperprolactinemia, somnolence. Unknown long-term effects on growth and sexual maturation.
- 1 Day – 5 Years
- Safety and efficacy not established age < 5 years. Unknown effects on growth, development. Risk of weight gain, cardiometabolic abnormalities.
- Rare risk of tardive dyskinesia, risk of hyperglycemia, weight gain, hyperlipidemia, hyperprolactinemia, somnolence. Unknown long-term effects on growth and sexual maturation.
- 5 Years – 18 Years
- Safety and efficacy not established age < 5 years. Unknown effects on growth, development. Risk of weight gain, cardiometabolic abnormalities.
- Rare risk of tardive dyskinesia, risk of hyperglycemia, weight gain, hyperlipidemia, hyperprolactinemia, somnolence. Unknown long-term effects on growth and sexual maturation.
Risperidone
- Severity Level:
2
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Risperidone
Limited data suggest low levels excreted w/no know adverse effect in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest low levels excreted w/no know adverse effect in infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Risperidone (po)
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognitive impairment, and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognitive decline, and death when used with senile dementia. Max 2mg/day. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotension. Gastrointestinal-May cause or worsen constipation. Renal-Titrate carefully w/renal impairment.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor. If you are using risperidone in combination with other medication to treat depression, also carefully read the drug information for the other medication.
| Infantile autism | |
| F84.0 | Autistic disorder |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Mixed bipolar I disorder | |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| F84.0 | Autistic disorder |
Formulary Reference Tool