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INVEGA (PALIPERIDONE)
- Schizoaffective disorder
- Schizophrenia
1.5 mg tablet,extended release 24 hr
- 2 tablets (3 mg) by oral route once daily in the morning
3 mg tablet,extended release 24 hr
- 1 tablet (3 mg) by oral route once daily in the morning
6 mg tablet,extended release 24 hr
- 1 tablet (6 mg) by oral route once daily in the morning
9 mg tablet,extended release 24 hr
- 1 tablet (9 mg) by oral route once daily in the morning
ER 1.5 mg tablet,extended release 24 hr
- 2 tablets (3 mg) by oral route once daily in the morning
ER 3 mg tablet,extended release 24 hr
- 1 tablet (3 mg) by oral route once daily in the morning
ER 6 mg tablet,extended release 24 hr
- 1 tablet (6 mg) by oral route once daily in the morning
ER 9 mg tablet,extended release 24 hr
- 1 tablet (9 mg) by oral route once daily in the morning
1.5 mg tablet,extended release
- 2 tablets (3 mg) by oral route once daily in the morning
3 mg tablet,extended release
- 1 tablet (3 mg) by oral route once daily in the morning
6 mg tablet,extended release
- 1 tablet (6 mg) by oral route once daily in the morning
9 mg tablet,extended release
- 1 tablet (9 mg) by oral route once daily in the morning
Schizoaffective disorder
- 2 tablets (3 mg) by oral route once daily in the morning
Schizophrenia
- 2 tablets (3 mg) by oral route once daily in the morning
- 1 tablet (3 mg) by oral route once daily in the morning
- 2 tablets (6 mg) by oral route once daily in the morning
- 1 tablet (6 mg) by oral route once daily in the morning
- 1 tablet (9 mg) by oral route once daily in the morning
- 2 tablets (12 mg) by oral route once daily in the morning
- dronedarone
- droperidol
- disopyramide
- Cordarone
- Coartem
- artemether-lumefantrine
- amiodarone in dextrose,iso-osm
- amiodarone
- metoclopramide HCl
- Metozolv Odt
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Reglan
Contraindicated
- Dolophine
- escitalopram oxalate
- Fareston
- dofetilide
- Diskets
- dasatinib
- Corvert
- citalopram
- chlorpromazine
- chloroquine phosphate
- Celexa
- Caprelsa
- cabergoline
- Betapace Af
- Betapace
- bedaquiline
- arsenic trioxide
- apomorphine
- Apokyn
- Geodon
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- Invirase
- isradipine
- Kaletra
- Lexapro
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- pasireotide
- Pentam
- pentamidine
- procainamide
- propafenone
- Qualaquin
- quinine sulfate
- Rythmol
- saquinavir mesylate
- Signifor
- Sirturo
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- tetrabenazine
- thioridazine
- Tikosyn
- toremifene
- Trisenox
- vandetanib
- Xenazine
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- dolasetron
- Donnatal
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- entacapone
- enzalutamide
- Eovist
- Epitol
- Equetro
- eribulin
- Esgic
- ezogabine
- Fatigue Relief Complex
- Fazaclo
- felbamate
- Felbatol
- fingolimod
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- Forfivo Xl
- Dilantin-125
- Dilantin Kapseal
- Dilantin Infatabs
- Dilantin Extended
- Dilantin
- crizotinib
- Comtan
- Complera
- Cold & Flu Fighter
- codeine-butalbital-ASA-caff
- Clozaril
- clozapine
- Cerebyx
- Cardene Sr
- Cardene Iv In Sodium Chloride
- Cardene Iv In Dextrose
- Cardene Iv
- carbidopa-levodopa-entacapone
- carbidopa-levodopa
- Carbatrol
- carbamazepine
- Capacet
- calcium-mag-B complex-D3-hrb61
- Butisol
- butalbital-aspirin-caffeine
- butalbital-acetaminophen-caff
- butalbital-acetaminophen
- butalbital-acetaminop-caf-cod
- Butalbital Compound-codeine
- Butalbital Compound W/codeine
- butabarbital
- bupropion HCl
- bupropion HBr
- Buproban
- Bupap
- budesonide-formoterol
- Brovana
- Belladonna-phenobarbital
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Avelox In Nacl (iso-osmotic)
- Avelox Abc Pack
- Avelox
- Astagraf Xl
- Ascomp With Codeine
- arformoterol
- Aplenzin
- Anzemet
- Amytal
- amobarbital
- amantadine HCl
- Aloxi
- alfuzosin
- Alagesic Lq
- Advair Hfa
- Advair Diskus
- Ablavar
- formoterol fumarate
- foscarnet
- Foscavir
- fosphenytoin
- gadofosveset trisodium
- gadoxetate
- Gilenya
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Hecoria
- indapamide
- isoniazid-rifamp-pyrazinamide
- Istodax
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- Luminal
- Lysodren
- Margesic
- Marten-tab
- Mirapex
- Mirapex Er
- mitotane
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Mysoline
- Nembutal Sodium
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- palonosetron
- pazopanib
- pentobarbital sodium
- Perforomist
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Potiga
- pramipexole
- primidone
- Prograf
- quetiapine
- Requip
- Requip Xl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- ropinirole
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- secobarbital sodium
- Seconal Sodium
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Sinemet
- Sinemet Cr
- Soltamox
- sorafenib
- St. John's wort
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tegretol
- Tegretol Xr
- telavancin
- telithromycin
- Tencon
- tizanidine
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- vit C-St. John wort-elder-hb30
- voriconazole
- Votrient
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Women's Complex
- Xalkori
- Xtandi
- Zanaflex
- Zebutal
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Zyban
- Neuroleptic malignant syndrome
Contraindicated
- Acute myocardial infarction
- Agranulocytosis
- Cataract surgery
- Chronic kidney disease stage 2 (mild) GFR 60-89 ml/min
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Congenital long QT syndrome
- Dehydration
- Esophageal compression
- Esophageal dysmotility
- Hypokalemia
- Hypomagnesemia
- Hypovolemia
- Parkinsonism
- Pregnancy
- Priapism
- Senile dementia
- Tardive dyskinesia
- Torsades de pointes
Severe
Moderate
- Acquired dystonia
- Acute confusion
- Angina
- Carcinoma of breast
- Cerebrovascular disorder
- Chronic heart failure
- Diabetes mellitus
- Diffuse lewy body disease
- Hyperlipidemia
- Hyperprolactinemia
- Intraoperative floppy iris syndrome
- Leukopenia
- Lower seizure threshold
- Metabolic syndrome X
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Predisposition to aspiration
- Seizure disorder
- Suicidal ideation
- Weight gain
INVEGA (PALIPERIDONE)
- Schizoaffective disorder
- Schizophrenia
- Akathisia
- Dyskinesia
- Extrapyramidal disease
- Parkinsonism
- Visual changes
- Abnormal sexual function
- Acquired dystonia
- Agitation
- Altered mental status
- Appetite changes
- Blurred vision
- Constipation
- Cough
- Diarrhea
- Dizziness
- Drowsy
- Dyspepsia
- Fatigue
- Headache disorder
- Increased appetite
- Injection site sequelae
- Insomnia
- Libido changes
- Nasal congestion
- Nausea
- Nervousness
- Pharyngitis
- Pruritus of skin
- Rhinitis
- Rhinorrhea
- Sedation
- Sialorrhea
- Skin rash
- Sore throat
- Symptoms of anxiety
- Tremor
- Upper respiratory infection
- Urinary incontinence
- Vomiting
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypotension
- Orthostatic hypotension
- Abdominal pain with cramps
- Acute confusion
- Arthralgias
- Ataxia
- Back pain
- Concentration difficulty
- Dyspnea
- Epistaxis
- Galactorrhea not associated with childbirth
- General weakness
- Hypercholesterolemia
- Hyperprolactinemia
- Hypertriglyceridemia
- Menstrual disorder
- Muscle weakness
- Myalgias
- Palpitations
- Seborrhea
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Accidental fall
- Agranulocytosis
- Altered consciousness
- Anaphylaxis
- Anemia
- Angioedema
- Aspiration pneumonia
- Atrial fibrillation
- Atrioventricular block
- Bradycardia
- Cerebral ischemia
- Cerebrovascular accident
- Diabetes mellitus
- DRESS syndrome
- Esophageal dysmotility
- Fever
- Gastrointestinal obstruction
- Heart block
- Hypertension
- Hypothermia
- Ileus
- Influenza
- Intraoperative floppy iris syndrome
- Jaundice
- Leukopenia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Pancreatitis
- Pituitary neoplasm
- Pneumonia
- Priapism
- Pulmonary thromboembolism
- Rhabdomyolysis
- Seizure disorder
- SIADH syndrome
- Sinus tachycardia
- Sleep apnea
- Tardive dyskinesia
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Tongue swelling
- Transient cerebral ischemia
- Water intoxication
Less Severe
- Alopecia
- Amenorrhea
- Anorexia
- Blepharospasm
- Cheilitis
- Complex sleep behavior
- Conjunctival hyperemia
- Disorder of ejaculation
- Disturbance of attention
- Dysarthria
- Dysgeusia
- Dysphagia
- Earache
- Edema
- Eyelid edema
- Fecal incontinence
- Flatulence
- Gastritis
- Gynecomastia
- Hypesthesia
- Hypoglycemic disorder
- Infection of ear
- Joint stiffness
- Lip swelling
- Mastalgia
- Muscle spasm
- Musculoskeletal pain
- Non-cardiac chest pain
- Ocular crusting
- Peripheral edema
- Photophobia
- Reduced visual acuity
- Retrograde ejaculation
- Sleep disorder
- Sleep walking disorder
- Syncope
- Tinnitus
- Urinary retention
- Urinary tract infection
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Paliperidone (Oral)
Risks of somnolence, weight gain, glucose, lipid abnormalities. Unknown long term effects on growth and development. Safety and efficacy not established in children age < 12 years.
Monitor weight and for glucose, lipid abnormalities. Risks include somnolence, akathisia, tremor, dystonia, anxiety, and tachycardia. Unknown long-term effects on growth and development.
- 1 Day – 12 Years
- Risks of somnolence, weight gain, glucose, lipid abnormalities. Unknown long term effects on growth and development. Safety and efficacy not established in children age < 12 years.
- Monitor weight and for glucose, lipid abnormalities. Risks include somnolence, akathisia, tremor, dystonia, anxiety, and tachycardia. Unknown long-term effects on growth and development.
- 12 Years – 18 Years
- Risks of somnolence, weight gain, glucose, lipid abnormalities. Unknown long term effects on growth and development. Safety and efficacy not established in children age < 12 years.
- Monitor weight and for glucose, lipid abnormalities. Risks include somnolence, akathisia, tremor, dystonia, anxiety, and tachycardia. Unknown long-term effects on growth and development.
Paliperidone
- Severity Level:
D
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Paliperidone
Based on risperidone data,low levels excreted w/no known adv effect on infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Based on risperidone data,low levels excreted w/no known adv effect on infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Paliperidone
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognit impair and inc fall risk. Avoid for behav probs of dementia or delirium unless fail nonpharm options. Inc risk of stroke, cognit decline, death when used w/dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Renal-Adj dose. Long-acting not rec'd. Cardiovascular-Inc risk of ostat hypotens, QT prolong. Gastrointestinal-May cause or worsen constip. Genitourinary-Urinary retention risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor. If you are using paliperidone in combination with other medication to treat depression, also carefully read the drug information for the other medication.
| Schizoaffective disorder | |
| F25 | Schizoaffective disorders |
| F25.0 | Schizoaffective disorder, bipolar type |
| F25.1 | Schizoaffective disorder, depressive type |
| F25.8 | Other schizoaffective disorders |
| F25.9 | Schizoaffective disorder, unspecified |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F25 | Schizoaffective disorders |
| F25.0 | Schizoaffective disorder, bipolar type |
| F25.1 | Schizoaffective disorder, depressive type |
| F25.8 | Other schizoaffective disorders |
| F25.9 | Schizoaffective disorder, unspecified |
Formulary Reference Tool