INVEGA HAFYERA (paliperidone palmitate)
- schizophrenia
- schizophrenia with mood changes
1,092 mg/3.5 mL intramuscular syringe
- Inject 1,092 mg by intramuscular route every 6 months
1,560 mg/5 mL intramuscular syringe
- Inject 1,560 mg by intramuscular route every 6 months
Default screening record
- Inject 1,560 mg by intramuscular route every 6 months
- Inject 1,092 mg by intramuscular route every 6 months
- Inject 3.5 milliliters (1,092 mg) by intramuscular route every 6 months
- Inject 5 milliliters (1,560 mg) by intramuscular route every 6 months
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- metoclopramide HCl
- Metozolv Odt
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Reglan
Contraindicated
- Apokyn
- apomorphine
- arsenic trioxide
- bedaquiline
- Betapace
- Betapace Af
- cabergoline
- Caprelsa
- Celexa
- chloroquine phosphate
- chlorpromazine
- citalopram
- Corvert
- dasatinib
- Diskets
- dofetilide
- Dolophine
- escitalopram oxalate
- Fareston
- Geodon
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- Invirase
- isradipine
- Kaletra
- Lexapro
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- pasireotide
- Pentam
- pentamidine
- procainamide
- propafenone
- Qualaquin
- quinine sulfate
- Rythmol
- saquinavir mesylate
- Signifor
- Sirturo
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- thioridazine
- Tikosyn
- toremifene
- Trisenox
- vandetanib
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Advair Diskus
- Advair Hfa
- Alagesic Lq
- alfuzosin
- Aloxi
- amantadine HCl
- amobarbital
- Amytal
- Anzemet
- Aplenzin
- arformoterol
- Ascomp With Codeine
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Brovana
- budesonide-formoterol
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cerebyx
- clozapine
- Clozaril
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Comtan
- crizotinib
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- dolasetron
- Donnatal
- Dulera
- Effexor Xr
- entacapone
- enzalutamide
- Eovist
- Epitol
- Equetro
- eribulin
- Esgic
- ezogabine
- Fatigue Relief Complex
- Fazaclo
- felbamate
- Felbatol
- fingolimod
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- Forfivo Xl
- formoterol fumarate
- foscarnet
- Foscavir
- fosphenytoin
- gadofosveset trisodium
- gadoxetate
- Gilenya
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Hecoria
- indapamide
- isoniazid-rifamp-pyrazinamide
- Istodax
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- Luminal
- Lysodren
- Margesic
- Marten-tab
- Mirapex
- Mirapex Er
- mitotane
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Mysoline
- Nembutal Sodium
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- palonosetron
- pazopanib
- pentobarbital sodium
- Perforomist
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Potiga
- pramipexole
- primidone
- Prograf
- quetiapine
- Requip
- Requip Xl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- ropinirole
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- secobarbital sodium
- Seconal Sodium
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Sinemet
- Sinemet Cr
- Soltamox
- sorafenib
- St. John's wort
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tegretol
- Tegretol Xr
- telavancin
- telithromycin
- Tencon
- tizanidine
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- vit C-St. John wort-elder-hb30
- voriconazole
- Votrient
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Women's Complex
- Xalkori
- Xtandi
- Zanaflex
- Zebutal
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Zyban
- Congenital long QT syndrome
- Neuroleptic malignant syndrome
Contraindicated
- Acute myocardial infarction
- Agranulocytosis
- Cataract surgery
- Chronic kidney disease stage 2 (mild) GFR 60-89 ml/min
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Dehydration
- Esophageal compression
- Esophageal dysmotility
- Hypokalemia
- Hypomagnesemia
- Hypovolemia
- Parkinsonism
- Pregnancy
- Priapism
- Senile dementia
- Tardive dyskinesia
- Torsades de pointes
Severe
Moderate
- Acquired dystonia
- Acute confusion
- Angina
- Carcinoma of breast
- Cerebrovascular disorder
- Chronic heart failure
- Diabetes mellitus
- Diffuse lewy body disease
- Hyperlipidemia
- Hyperprolactinemia
- Intraoperative floppy iris syndrome
- Leukopenia
- Lower seizure threshold
- Metabolic syndrome x
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Predisposition to aspiration
- Seizure disorder
- Suicidal ideation
- Weight gain
INVEGA HAFYERA (paliperidone palmitate)
- schizophrenia
- schizophrenia with mood changes
- Akathisia
- Dyskinesia
- Extrapyramidal disease
- Parkinsonism
- Tachycardia
- Acquired dystonia
- Constipation
- Dizziness
- Drowsy
- Dyspepsia
- Fatigue
- Headache disorder
- Injection site sequelae
- Pharyngitis
- Sialorrhea
- Tremor
- Vomiting
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Bundle branch block
- Hyperglycemia
- Hypotension
- Orthostatic hypotension
- Acute abdominal pain
- Anorexia
- Back pain
- Blurred vision
- Cough
- Dysarthria
- Galactorrhea not associated with childbirth
- General weakness
- Hypercholesterolemia
- Hyperkinesis
- Hyperprolactinemia
- Hypertriglyceridemia
- Increased appetite
- Insomnia
- Menstrual disorder
- Myalgia
- Nausea
- Palpitations
- Rhinitis
- Sore throat
- Symptoms of anxiety
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Accidental fall
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aspiration pneumonia
- Atrioventricular block
- Bradycardia
- Catatonia
- Cerebral ischemia
- Cerebrovascular accident
- Diabetes mellitus
- Esophageal dysmotility
- Fever
- Gastrointestinal obstruction
- Heart block
- Hypertension
- Ileus
- Increased alanine transaminase
- Increased aspartate transaminase
- Leukopenia
- Muscle rigidity
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Oculogyric crisis
- Opisthotonus
- Priapism
- Prolonged QT interval
- Rhabdomyolysis
- Seizure disorder
- Sinus node dysfunction
- Sinus tachycardia
- Tardive dyskinesia
- Tongue swelling
- Transient cerebral ischemia
Less Severe
- Acute confusion
- Agitation
- Altered mental status
- Amenorrhea
- Arthralgia
- Complex sleep behavior
- Dysphagia
- Dyspnea
- Edema
- Epistaxis
- Flatulence
- Gynecomastia
- Hypoesthesia
- Muscle spasm
- Musculoskeletal pain
- Nasal congestion
- Nervousness
- Pruritus of skin
- Retrograde ejaculation
- Skin rash
- Sleep disorder
- Sleep walking disorder
- Syncope
- Urinary incontinence
- Urinary retention
- Urinary tract infection
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Paliperidone (IM)
Acute risks: drowsiness, akathisia, extrapyramidal effects. Unknown long term effects on growth and sexual maturation. No safety and efficacy for IM dose form. Not recommended per manufacturer.
- 1 Day – 18 Years
- Acute risks: drowsiness, akathisia, extrapyramidal effects. Unknown long term effects on growth and sexual maturation. No safety and efficacy for IM dose form. Not recommended per manufacturer.
Paliperidone
- Severity Level:
D
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Paliperidone
Low levels excrt, monitor infant for abnormal movements
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Low levels excrt, monitor infant for abnormal movements |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Paliperidone
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognit impair and inc fall risk. Avoid for behav probs of dementia or delirium unless fail nonpharm options. Inc risk of stroke, cognit decline, death when used w/dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Renal-Adj dose. Long-acting not rec'd. Cardiovascular-Inc risk of ostat hypotens, QT prolong. Gastrointestinal-May cause or worsen constip. Genitourinary-Urinary retention risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
Schizoaffective disorder | |
F25 | Schizoaffective disorders |
F25.0 | Schizoaffective disorder, bipolar type |
F25.1 | Schizoaffective disorder, depressive type |
F25.8 | Other schizoaffective disorders |
F25.9 | Schizoaffective disorder, unspecified |
Schizophrenia | |
F20 | Schizophrenia |
F20.0 | Paranoid schizophrenia |
F20.1 | Disorganized schizophrenia |
F20.2 | Catatonic schizophrenia |
F20.3 | Undifferentiated schizophrenia |
F20.5 | Residual schizophrenia |
F20.8 | Other schizophrenia |
F20.81 | Schizophreniform disorder |
F20.89 | Other schizophrenia |
F20.9 | Schizophrenia, unspecified |
0-9 | A-Z |
---|---|
F20 | Schizophrenia |
F20.0 | Paranoid schizophrenia |
F20.1 | Disorganized schizophrenia |
F20.2 | Catatonic schizophrenia |
F20.3 | Undifferentiated schizophrenia |
F20.5 | Residual schizophrenia |
F20.8 | Other schizophrenia |
F20.81 | Schizophreniform disorder |
F20.89 | Other schizophrenia |
F20.9 | Schizophrenia, unspecified |
F25 | Schizoaffective disorders |
F25.0 | Schizoaffective disorder, bipolar type |
F25.1 | Schizoaffective disorder, depressive type |
F25.8 | Other schizoaffective disorders |
F25.9 | Schizoaffective disorder, unspecified |