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RYBREVANT (amivantamab-vmjw)
- Non-small cell lung cancer with EGFR exon 20 insertion
50 mg/mL intravenous solution
- Infuse 1,050 mg by intravenous route every 2 weeks
Default screening record
- Infuse 350 mg by intravenous route once weekly for 1 week
- Infuse 1,050 mg by intravenous route every 2 weeks
- Infuse 1,400 mg by intravenous route every 2 weeks
- Infuse 700 mg by intravenous route every 2 weeks
- Infuse 350 mg by intravenous route every 2 weeks
- Infuse 700 mg by intravenous route once weekly for 2 weeks
- Infuse 700 mg by intravenous route once weekly for 1 week
- Infuse 350 mg by intravenous route once on day 1 (week 1)
- Infuse 700 mg by intravenous route once on day 2 (week 1)
- Infuse 1,050 mg by intravenous route once on day 2 (week 1)
- Infuse 1,050 mg by intravenous route once weekly (weeks 2 to 4)
- Infuse 1,400 mg by intravenous route once weekly (weeks 2 to 4)
- Infuse 700 mg by intravenous route once weekly (weeks 2 to 4)
- Infuse 350 mg by intravenous route once weekly (weeks 3 to 4)
- None
Contraindicated
- None
Severe
Moderate
- None
- Lactation
Contraindicated
- Interstitial lung disease
- Interstitial pneumonitis
- Pregnancy
Severe
Moderate
- None
RYBREVANT (amivantamab-vmjw)
- Non-small cell lung cancer with EGFR exon 20 insertion
- Hypokalemia
- Hyponatremia
- Hypophosphatemia
- Hypotension
- Increased alanine transaminase
- Increased alkaline phosphatase
- Increased aspartate transaminase
- Lymphopenia
- Chest discomfort
- Chills
- Constipation
- Cough
- Dyspnea
- Edema
- Fatigue
- Flushing
- Hypoalbuminemia
- Musculoskeletal pain
- Nausea
- Paronychia
- Skin rash
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Hemorrhage
- Pneumonia
- Pulmonary thromboembolism
- Acute abdominal pain
- Anorexia
- Diarrhea
- Dizziness
- Dry skin
- Fever
- Headache disorder
- Peripheral sensory neuropathy
- Pruritus of skin
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Bullous dermatitis
- Interstitial lung disease
- Interstitial pneumonitis
- Keratitis
- Pleural effusions
- Toxic epidermal necrolysis
- Uveitis
Less Severe
- Acneiform eruption
- Blurred vision
- Conjunctival hyperemia
- Dry eye
- Muscle weakness
- Ocular itching
- Visual changes
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Amivantamab-vmjw
Safety and effectiveness not established in pediatric patients.
- 1 Day – 18 Years
- Safety and effectiveness not established in pediatric patients.
Amivantamab-vmjw
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Amivantamab-vmjw
Mfg rec avoiding during tx and for 3 mon after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfg rec avoiding during tx and for 3 mon after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Non-small cell lung cancer with EGFR exon 20 insertion | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool