ERLEADA (apalutamide)
- Metastatic castration-sensitive prostate cancer
- Non-metastatic castration-resistant prostate cancer
60 mg tablet
- 4 tablets (240 mg) by oral route once daily at the same time each day
Metastatic castration-sensitive prostate cancer
- 2 tablets (120 mg) by oral route once daily at the same time each day
- 3 tablets (180 mg) by oral route once daily at the same time each day
- 4 tablets (240 mg) by oral route once daily at the same time each day
Non-metastatic castration-resistant prostate cancer
- 2 tablets (120 mg) by oral route once daily at the same time each day
- 3 tablets (180 mg) by oral route once daily at the same time each day
- 4 tablets (240 mg) by oral route once daily at the same time each day
- Adalat Cc
- Afeditab Cr
- artemether-lumefantrine
- boceprevir
- Coartem
- Complera
- Edurant
- emtricitab-rilpivirine-tenofov
- Incivek
- Latuda
- lurasidone
- natalizumab
- Nifedical Xl
- nifedipine
- Procardia
- Procardia Xl
- rilpivirine
- sofosbuvir
- Sovaldi
- telaprevir
- Tysabri
- Vfend
- Vfend Iv
- Victrelis
- voriconazole
Contraindicated
- Afinitor
- Afinitor Disperz
- amiodarone
- amiodarone in dextrose,iso-osm
- apixaban
- aprepitant
- Astagraf Xl
- axitinib
- bedaquiline
- bortezomib
- Bosulif
- bosutinib
- Brilinta
- cabozantinib
- Caprelsa
- Cometriq
- Cordarone
- crizotinib
- cyclosporine
- cyclosporine modified
- dabrafenib
- dasatinib
- dextromethorphan-quinidine
- disopyramide
- dolutegravir
- dronedarone
- droperidol
- Eliquis
- elvitegr-cobicist-emtric-tenof
- Emend
- enzalutamide
- erlotinib
- everolimus
- Fareston
- fosaprepitant
- Gengraf
- Geodon
- Gleevec
- guanfacine
- Hecoria
- ibrutinib
- imatinib
- Imbruvica
- Inlyta
- Intuniv Er
- Istodax
- ivacaftor
- Jentadueto
- Kalydeco
- lapatinib
- linagliptin
- linagliptin-metformin
- mefloquine
- Multaq
- Neoral
- Nexavar
- Nexterone
- nilotinib
- Norpace
- Norpace Cr
- Nuedexta
- Olysio
- Orap
- Pacerone
- pazopanib
- pimozide
- pomalidomide
- Pomalyst
- Prograf
- Qualaquin
- quetiapine
- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- Rapamune
- rivaroxaban
- romidepsin
- Samsca
- Sandimmune
- Seroquel Xr
- simeprevir
- sirolimus
- Sirturo
- Soltamox
- sorafenib
- Sprycel
- Stribild
- sunitinib
- Sutent
- tacrolimus
- Tafinlar
- tamoxifen
- Tarceva
- Tasigna
- temsirolimus
- Tenex
- thioridazine
- ticagrelor
- Tivicay
- tolvaptan
- toremifene
- Torisel
- Tradjenta
- Tykerb
- vandetanib
- Velcade
- Votrient
- Xalkori
- Xarelto
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Ablavar
- Adoxa
- afatinib
- alfuzosin
- alprazolam
- Alprazolam Intensol
- amoxicil-clarithromy-lansopraz
- Anucort-hc
- Anusol-hc
- Anzemet
- Apokyn
- apomorphine
- aripiprazole
- Aristospan Intra-articular
- Aristospan Intralesional
- Aromasin
- arsenic trioxide
- Astramorph-pf
- Ativan
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Avidoxy
- Avinza
- betamethasone acet & sod phos
- Betapace
- Betapace Af
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- bosentan
- budesonide
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- Butrans
- Celestone Soluspan
- Celexa
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- clarithromycin
- clozapine
- Clozaril
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Daliresp
- Depo-medrol
- Depodur (pf)
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- Duramorph (pf)
- Entocort Ec
- eribulin
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- escitalopram oxalate
- exemestane
- Ez Use Joint-tunnel-trigger
- ezogabine
- Fazaclo
- fingolimod
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- gadofosveset trisodium
- Gilenya
- Gilotrif
- Grx Hicort 25
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Iclusig
- Invirase
- Kadian
- Kaletra
- Kenalog
- Ketek
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lopinavir-ritonavir
- lorazepam
- Lorazepam Intensol
- macitentan
- Medrol
- Medrol (pak)
- methadone
- Methadone Intensol
- Methadose
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- midazolam
- midazolam (PF)
- Millipred
- Millipred Dp
- Monodox
- Morgidox
- morphine
- morphine (PF)
- morphine concentrate
- morphine liposomal (PF)
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Ms Contin
- Niravam
- norfloxacin
- Noroxin
- Noxafil
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Opsumit
- Oracea
- Orapred
- Orapred Odt
- ospemifene
- Osphena
- pasireotide
- Pediapred
- Physicians Ez Use M-pred
- ponatinib
- posaconazole
- Potiga
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prevpac
- Proctocort
- propafenone
- Rayos
- Rectacort-hc
- regorafenib
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- roflumilast
- Rythmol
- saquinavir mesylate
- Seroquel
- Signifor
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sorine
- sotalol
- Sotalol Af
- Stivarga
- Suboxone
- telavancin
- telithromycin
- tetrabenazine
- Tikosyn
- Tracleer
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triazolam
- Trisenox
- Uceris
- Uroxatral
- Valium
- Veripred 20
- Versacloz
- Vibativ
- Vibramycin
- Xanax
- Xanax Xr
- Xenazine
- Zofran
- Zofran Odt
- Zubsolv
- Zuplenz
- Congenital long QT syndrome
- Pregnancy
Contraindicated
- None
Severe
Moderate
- None
ERLEADA (apalutamide)
- Metastatic castration-sensitive prostate cancer
- Non-metastatic castration-resistant prostate cancer
- Accidental fall
- Anemia
- Fracture
- Hypertension
- Leukopenia
- Lymphopenia
- Anorexia
- Arthralgias
- Diarrhea
- Fatigue
- Flushing
- Hypercholesterolemia
- Hyperglycemia
- Hypertriglyceridemia
- Nausea
- Peripheral edema
- Skin rash
- Weight loss
More Frequent
Severe
Less Severe
- Heart failure
- Hyperkalemia
- Myocardial ischemia
- Hypothyroidism
- Pruritus of skin
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Infection
- Prolonged QT interval
- Seizure disorder
Less Severe
- Hematuria
Contraindicated
None
Severe Precaution
Apalutamide
Androgen receptor inhibitor, potential developmental toxicity. No safety and efficacy.
- 1 Day – 18 Years
- Androgen receptor inhibitor, potential developmental toxicity. No safety and efficacy.
Management or Monitoring Precaution
None
Apalutamide
- Severity Level:
1
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Apalutamide
Not indicated in females, insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Not indicated in females, insufficient data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Apalutamide
General-Greater risk of grade 3-4 reactions in patients >75 years or older Endocrine-Risk of bone fractures. Falls occurred with increased frequency in elderly (8-19%). Evaluate for fall risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | Y |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Metastatic castration-sensitive prostate cancer | |
C61 | Malignant neoplasm of prostate |
Z19.1 | Hormone sensitive malignancy status |
Non-metastatic castration-resistant prostate cancer | |
C61 | Malignant neoplasm of prostate |
0-9 | A-Z |
---|---|
C61 | Malignant neoplasm of prostate |
C61 | Malignant neoplasm of prostate |
Z19.1 | Hormone sensitive malignancy status |