TIVORBEX (indomethacin, submicronized)

Moderate

• A-hydrocort

• A-methapred

• abciximab

• Accupril

• Accuretic

• acebutolol

• Aceon

• adefovir

• Adult Low Dose Aspirin

• Aggrenox

• Alka-seltzer

• Alka-seltzer Extra Strength

• Alka-seltzer Original

• Alka-seltzer Pm

• Altace

• amiloride

• amiloride-hydrochlorothiazide

• amlodipine-benazepril

• amlodipine-olmesartan

• amlodipine-valsartan

• amlodipine-valsartan-hcthiazid

• Angeliq

• Antacid & Pain Relief

• Anucort-hc

• Anusol-hc

• Aristospan Intra-articular

• Aristospan Intralesional

• Arixtra

• ASA-acetaminophen-caff-buffers

• Aspir-81

• Aspir-low

• Aspir-trin

• aspirin

• Aspirin Childrens

• Aspirin Low Dose

• Aspirin Low-strength

• aspirin, buffered

• aspirin-calcium carbonate

• aspirin-diphenhydramine

• aspirin-sod bicarb-citric acid

• Astagraf Xl

• Atacand

• Atacand Hct

• atenolol

• atenolol-chlorthalidone

• Atripla

• Avalide

• Avapro

• azilsartan med-chlorthalidone

• azilsartan medoxomil

• Azor

• Bayer Advanced

• Bayer Aspirin

• Bayer Chewable Aspirin

• Bayer Childrens Aspirin

• Bayer Plus Extra Strength

• benazepril

• benazepril-hydrochlorothiazide

• Benicar

• Benicar Hct

• betamethasone acet & sod phos

• Betapace

• Betapace Af

• betaxolol

• Beyaz

• bisoprolol fumarate

• bisoprolol-hydrochlorothiazide

• Brevibloc

• Brevibloc In Nacl (iso-osm)

• Brilinta

• Brintellix

• Brisdelle

• budesonide

• Buffered Aspirin

• Bufferin

• bumetanide

• Bystolic

• candesartan

• candesartan-hydrochlorothiazid

• captopril

• captopril-hydrochlorothiazide

• Celestone Soluspan

• Celexa

• Child Aspirin

• Children's Aspirin

• cilostazol

• citalopram

• clopidogrel

• colchicine-probenecid

• Colocort

• Complera

• Corgard

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Corzide

• Cozaar

• cyclosporine

• cyclosporine modified

• Cymbalta

• dalteparin (porcine)

• Demadex

• Depo-medrol

• desvenlafaxine

• desvenlafaxine fumarate

• desvenlafaxine succinate

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• Digox

• digoxin

• Diovan Hct

• dipyridamole-aspirin

• drospirenone-e.estradiol-lm.FA

• drospirenone-estradiol

• drospirenone-ethinyl estradiol

• duloxetine

• Dutoprol

• Dyazide

• Dyrenium

• E.c. Prin

• Ecotrin

• Ecotrin Low Strength

• Edarbi

• Edarbyclor

• efavirenz-emtricitabin-tenofov

• Efferves Pain Relief Antacid

• Effervescent Antacid

• Effervescent Pain Relief

• Effervescent Pain Reliever

• Effexor Xr

• Elmiron

• elvitegr-cobicist-emtric-tenof

• emtricitab-rilpivirine-tenofov

• emtricitabine-tenofovir

• enalapril maleate

• enalapril-hydrochlorothiazide

• enalaprilat

• enoxaparin

• Enteric Coated Aspirin

• Entocort Ec

• Epaned

• eprosartan

• eprosartan-hydrochlorothiazide

• eptifibatide

• erlotinib

• escitalopram oxalate

• esmolol

• esmolol in NaCl (iso-osm)

• ethacrynate sodium

• Exforge

• Exforge Hct

• Extra Strength Bayer

• Ez Use Joint-tunnel-trigger

• Fetzima

• First-duke's

• First-mary's Mouthwash

• Flo-pred

• fludrocortisone

• fluoxetine

• fluvoxamine

• fondaparinux

• fosinopril

• fosinopril-hydrochlorothiazide

• Fragmin

• furosemide

• Gengraf

• Gianvi (28)

• Grx Hicort 25

• Hecoria

• Hemril-30

• heparin (porcine)

• heparin (porcine) in D5W

• heparin(porcine) in 0.45% NaCl

• heparin, porcine (PF)

• Hepsera

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• Hyzaar

• Inderal La

• Inderal Xl

• Innopran Xl

• Integrilin

• irbesartan

• irbesartan-hydrochlorothiazide

• Kenalog

• Khedezla

• Lanoxin

• Lanoxin Pediatric

• Lasix

• Levatol

• levomilnacipran

• Lexapro

• lisinopril

• lisinopril-hydrochlorothiazide

• Lite Coat Aspirin

• lithium carbonate

• lithium citrate

• Lithobid

• Lo-dose Aspirin

• Lopressor

• Lopressor Hct

• Loryna (28)

• losartan

• losartan-hydrochlorothiazide

• Lotensin

• Lotrel

• Lovenox

• Luvox Cr

• Mavik

• Maxzide

• Maxzide-25Mg

• Medi-seltzer

• Medrol

• Medrol (pak)

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• metoprolol su-hydrochlorothiaz

• metoprolol succinate

• metoprolol ta-hydrochlorothiaz

• metoprolol tartrate

• Micardis

• Micardis Hct

• Millipred

• Millipred Dp

• milnacipran

• moexipril

• moexipril-hydrochlorothiazide

• nadolol

• nadolol-bendroflumethiazide

• nebivolol

• Neoral

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• Ocella

• olanzapine-fluoxetine

• olmesartan

• olmesartan-amlodipin-hcthiazid

• olmesartan-hydrochlorothiazide

• Orapred

• Orapred Odt

• paroxetine HCl

• paroxetine mesylate

• Paxil

• Paxil Cr

• Pediapred

• penbutolol

• pentosan polysulfate sodium

• perindopril erbumine

• Pexeva

• Physicians Ez Use M-pred

• pindolol

• Plavix

• Pletal

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• Prinivil

• Pristiq

• probenecid

• Proctocort

• Prograf

• propranolol

• propranolol-hydrochlorothiazid

• Prozac

• Prozac Weekly

• quinapril

• quinapril-hydrochlorothiazide

• ramipril

• Rapamune

• Rayos

• Rectacort-hc

• Reopro

• Safyral

• Sandimmune

• Sarafem

• Savella

• Sectral

• sertraline

• sirolimus

• Sodium Edecrin

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Sorine

• sotalol

• Sotalol Af

• St Joseph Aspirin

• St. Joseph Aspirin

• Stribild

• Syeda

• Symbyax

• tacrolimus

• Tarceva

• Tarka

• telmisartan

• telmisartan-amlodipine

• telmisartan-hydrochlorothiazid

• tenofovir disoproxil fumarate

• Tenoretic 100

• Tenoretic 50

• Tenormin

• Teveten

• Teveten Hct

• ticagrelor

• timolol maleate

• Toprol Xl

• torsemide

• trandolapril

• trandolapril-verapamil

• Tri-buffered Aspirin

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• triamterene

• triamterene-hydrochlorothiazid

• Tribenzor

• Truvada

• Twynsta

• Uceris

• Uniretic

• Univasc

• valsartan-hydrochlorothiazide

• Vanquish

• Vaseretic

• Vasotec

• venlafaxine

• Veripred 20

• Vestura (28)

• Viibryd

• vilazodone

• Viread

• vortioxetine

• Women's Aspirin With Calcium

• Yasmin (28)

• Yaz 28

• Zarah

• Zebeta

• Zestoretic

• Zestril

• Ziac

• Zoloft

Moderate

• Chronic heart failure

• Disease of liver

• Hypertension

• Seizure disorder

• Ulcerative colitis

Indomethacin

• Severity Level:

  1

• Additional Notes: Fda c before 30wks;premature closure of ductus arteriosus;early miscarriage risk

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Indomethacin

Insufficient human data available; low levels found in breastmilk

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Insufficient human data available; low levels found in breastmilk

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

Indomethacin

Gastrointestinal-Risk for ulceration or serious GI bleed; highest with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension or CHF. Risk of MI and stroke. This risk may occur early in treatment and increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated with CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	Y	N	N

BEERS: Y     HEDIS: Y     STOPP: Y

Precaution Exists

None

No Known Risk

None

0-9	A-Z
G89.1	Acute pain, not elsewhere classified
G89.11	Acute pain due to trauma
G89.18	Other acute postprocedural pain