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ZYNYZ (retifanlimab-dlwr)
- Merkel cell carcinoma
500 mg/20 mL intravenous solution
- Infuse 500 mg over 30 minute(s) by intravenous route every 4 weeks
Default screening record
- Infuse 500 mg over 30 minute(s) by intravenous route every 4 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactation
Contraindicated
- Pregnancy
Severe
Moderate
- Abnormal hepatic function tests
- Diabetes mellitus
- Hyperthyroidism
- Hypothyroidism
- Kidney disease with reduction in GFR
ZYNYZ (retifanlimab-dlwr)
- Merkel cell carcinoma
- None
- Diarrhea
- Elevated serum lipase
- Fatigue
- Fever
- Musculoskeletal pain
- Nausea
- Pruritus of skin
- Skin rash
More Frequent
Severe
Less Severe
- Autoimmune hepatitis
- Colitis
- Hyperthyroidism
- Interstitial nephritis
- Interstitial pneumonitis
- Hypothyroidism
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Adrenocortical insufficiency
- Aplastic anemia
- Atrial fibrillation
- Diabetes mellitus
- DRESS syndrome
- Duodenitis
- Eaton-lambert syndrome
- Encephalitis
- Gastritis
- Guillain-barre syndrome
- Hemolytic anemia
- Hemophagocytic lymphohistiocytosis
- Histiocytic necrotizing lymphadenitis
- Hypoparathyroidism
- Hypophysitis
- Idiopathic thrombocytopenic purpura
- Iritis
- Meningitis
- Myelitis
- Myocarditis
- Myositis
- Organ transplant rejection
- Pancreatitis
- Pericarditis
- Polymyalgia rheumatica
- Polyneuropathy
- Rhabdomyolysis
- Sarcoidosis
- Stevens-johnson syndrome
- Thyroiditis
- Toxic epidermal necrolysis
- Uveitis
- Vasculitis
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
retifanlimab-dlwr
No established safety and efficacy in pediatric patients age < 18 years.
- 1 Day – 18 Years
- No established safety and efficacy in pediatric patients age < 18 years.
Retifanlimab-dlwr
- Severity Level:
D
- Additional Notes: Based on drug pharmacology fetal loss and/or dev tox may occur
Contraindicated
Retifanlimab-dlwr
Mfr recommends avoiding breastfeeding during tx and 4 months after last dose
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfr recommends avoiding breastfeeding during tx and 4 months after last dose |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Merkel cell carcinoma | |
C4A | Merkel cell carcinoma |
C4A.0 | Merkel cell carcinoma of lip |
C4A.1 | Merkel cell carcinoma of eyelid, including canthus |
C4A.10 | Merkel cell carcinoma of unspecified eyelid, including canthus |
C4A.11 | Merkel cell carcinoma of right eyelid, including canthus |
C4A.111 | Merkel cell carcinoma of right upper eyelid, including canthus |
C4A.112 | Merkel cell carcinoma of right lower eyelid, including canthus |
C4A.12 | Merkel cell carcinoma of left eyelid, including canthus |
C4A.121 | Merkel cell carcinoma of left upper eyelid, including canthus |
C4A.122 | Merkel cell carcinoma of left lower eyelid, including canthus |
C4A.2 | Merkel cell carcinoma of ear and external auricular canal |
C4A.20 | Merkel cell carcinoma of unspecified ear and external auricular canal |
C4A.21 | Merkel cell carcinoma of right ear and external auricular canal |
C4A.22 | Merkel cell carcinoma of left ear and external auricular canal |
C4A.3 | Merkel cell carcinoma of other and unspecified parts of face |
C4A.30 | Merkel cell carcinoma of unspecified part of face |
C4A.31 | Merkel cell carcinoma of nose |
C4A.39 | Merkel cell carcinoma of other parts of face |
C4A.4 | Merkel cell carcinoma of scalp and neck |
C4A.5 | Merkel cell carcinoma of trunk |
C4A.51 | Merkel cell carcinoma of anal skin |
C4A.52 | Merkel cell carcinoma of skin of breast |
C4A.59 | Merkel cell carcinoma of other part of trunk |
C4A.6 | Merkel cell carcinoma of upper limb, including shoulder |
C4A.60 | Merkel cell carcinoma of unspecified upper limb, including shoulder |
C4A.61 | Merkel cell carcinoma of right upper limb, including shoulder |
C4A.62 | Merkel cell carcinoma of left upper limb, including shoulder |
C4A.7 | Merkel cell carcinoma of lower limb, including hip |
C4A.70 | Merkel cell carcinoma of unspecified lower limb, including hip |
C4A.71 | Merkel cell carcinoma of right lower limb, including hip |
C4A.72 | Merkel cell carcinoma of left lower limb, including hip |
C4A.8 | Merkel cell carcinoma of overlapping sites |
C4A.9 | Merkel cell carcinoma, unspecified |
C7B.1 | Secondary merkel cell carcinoma |
0-9 | A-Z |
---|---|
C4A | Merkel cell carcinoma |
C4A.0 | Merkel cell carcinoma of lip |
C4A.1 | Merkel cell carcinoma of eyelid, including canthus |
C4A.10 | Merkel cell carcinoma of unspecified eyelid, including canthus |
C4A.11 | Merkel cell carcinoma of right eyelid, including canthus |
C4A.111 | Merkel cell carcinoma of right upper eyelid, including canthus |
C4A.112 | Merkel cell carcinoma of right lower eyelid, including canthus |
C4A.12 | Merkel cell carcinoma of left eyelid, including canthus |
C4A.121 | Merkel cell carcinoma of left upper eyelid, including canthus |
C4A.122 | Merkel cell carcinoma of left lower eyelid, including canthus |
C4A.2 | Merkel cell carcinoma of ear and external auricular canal |
C4A.20 | Merkel cell carcinoma of unspecified ear and external auricular canal |
C4A.21 | Merkel cell carcinoma of right ear and external auricular canal |
C4A.22 | Merkel cell carcinoma of left ear and external auricular canal |
C4A.3 | Merkel cell carcinoma of other and unspecified parts of face |
C4A.30 | Merkel cell carcinoma of unspecified part of face |
C4A.31 | Merkel cell carcinoma of nose |
C4A.39 | Merkel cell carcinoma of other parts of face |
C4A.4 | Merkel cell carcinoma of scalp and neck |
C4A.5 | Merkel cell carcinoma of trunk |
C4A.51 | Merkel cell carcinoma of anal skin |
C4A.52 | Merkel cell carcinoma of skin of breast |
C4A.59 | Merkel cell carcinoma of other part of trunk |
C4A.6 | Merkel cell carcinoma of upper limb, including shoulder |
C4A.60 | Merkel cell carcinoma of unspecified upper limb, including shoulder |
C4A.61 | Merkel cell carcinoma of right upper limb, including shoulder |
C4A.62 | Merkel cell carcinoma of left upper limb, including shoulder |
C4A.7 | Merkel cell carcinoma of lower limb, including hip |
C4A.70 | Merkel cell carcinoma of unspecified lower limb, including hip |
C4A.71 | Merkel cell carcinoma of right lower limb, including hip |
C4A.72 | Merkel cell carcinoma of left lower limb, including hip |
C4A.8 | Merkel cell carcinoma of overlapping sites |
C4A.9 | Merkel cell carcinoma, unspecified |
C7B.1 | Secondary merkel cell carcinoma |
Formulary Reference Tool