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ZOMIG (ZOLMITRIPTAN)
- Migraine
2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
5 mg tablet
- 1 tablet (5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
5 mg tablet
- 1 tablet (5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
2.5 mg nasal spray
- Spray 1 spray (2.5 mg) by intranasal route once; if headache returns,the dose may be repeated after 2 hrs, not to exceed 10 mg in 24 hours
5 mg nasal spray
- Spray 1 spray (5 mg) by intranasal route once; if headache returns, the dose may be repeated after 2 hrs, not to exceed 10 mg in 24 hours
2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
5 mg tablet
- 1 tablet (5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
Migraine
- 2 tablets (5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
- 1 tablet (5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
- Spray 1 spray (5 mg) by intranasal route once; if headache returns, the dose may be repeated after 2 hrs, not to exceed 10 mg in 24 hours
- one-half tablet (1.25 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
- 1 tablet (2.5 mg) by oral route once; if headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within 24 hours
- Azilect
- bromocriptine
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- methylergonovine
- Migergot
- Migranal
- Nardil
- Parlodel
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Conzip
- Nucynta
- Nucynta Er
- Synapryn
- tapentadol
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Brintellix
- Brisdelle
- Celexa
- cimetidine
- citalopram
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- duloxetine
- Effexor Xr
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- Heartburn Relief
- Khedezla
- levomilnacipran
- Lexapro
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- Pristiq
- Prozac
- Prozac Weekly
- Sarafem
- Savella
- sertraline
- Symbyax
- Tagamet Hb
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- Zoloft
- Acute myocardial infarction
- Angina
- Cerebral ischemia
- Cerebrovascular accident
- Coronary artery disease
- Hemiplegic migraine
- Ischemic bowel disease
- Myocardial ischemia
- Peripheral vascular disease
- Prinzmetal angina
- Serotonin syndrome
- Severe uncontrolled hypertension
Contraindicated
- Cardiac arrhythmia
- Increased cardiovascular event risk
- Raynaud's phenomenon
- Severe hepatic disease
Severe
Moderate
- Hypertension
- Severe renal impairment
ZOMIG (ZOLMITRIPTAN)
- Migraine
- Chest pain
- Paresthesia
- Dizziness
- Drowsy
- Dysgeusia
- General weakness
- Hypesthesia
- Jaw pain
- Nausea
- Paresthesia
More Frequent
Severe
Less Severe
- Cardiac arrhythmia
- Gastroenteritis
- Hypertension
- Sore throat
- Agitation
- Arthralgias
- Chills
- Depersonalization
- Depression
- Drowsy
- Dysgeusia
- Dyspepsia
- Dysphagia
- Ecchymosis
- Edema
- Facial edema
- General weakness
- Hyperhidrosis
- Mouth irritation
- Myalgias
- Nasal passage irritation
- Nausea
- Palpitations
- Polyuria
- Pruritus of skin
- Sensation of warmth
- Skin rash
- Symptoms of anxiety
- Syncope
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Angina
- Angioedema
- Cerebrovascular accident
- Chest tightness
- Coronary artery spasm
- Hypersensitivity drug reaction
- Intracerebral hemorrhage
- Ischemic bowel disease
- Ischemic colitis
- Leukopenia
- Myocardial ischemia
- Peripheral vascular disease
- Serotonin syndrome
- Splenic infarction
- Subarachnoid intracranial hemorrhage
- Vasospastic diseases
- Ventricular fibrillation
- Ventricular tachycardia
Less Severe
- Abdominal pain with cramps
- Dysphagia
- Insomnia
- Jaw pain
- Medication overuse headache
- Neck stiffness
- Palpitations
- Raynaud's phenomenon
- Throat constriction
- Visual changes
- Vomiting
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Zolmitriptan (Nasal)
No safety and efficacy established age < 12 years.
No established efficacy in pediatric migraine study.
- 1 Day – 12 Years
- No safety and efficacy established age < 12 years.
- 1 Day – 18 Years
- No safety and efficacy established age < 12 years.
Zolmitriptan (Oral)
No safety and efficacy established age < 12 years.
No established efficacy in pediatric migraine study.
- 1 Day – 12 Years
- No established efficacy in pediatric migraine study.
- 1 Day – 18 Years
- No established efficacy in pediatric migraine study.
Zolmitriptan
- Severity Level:
2
- Additional Notes: Insuff human data; animal studies show developmental toxicity w/ 280-5000 x mrhd
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Zolmitriptan
Insufficient human data available; excreted in rat studies
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available; excreted in rat studies |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Zolmitriptan
Hepatic-Elderly patients are more likely to have decreased hepatic function thus potentially decreasing drug clearance. Cardiovascular-Assess patient for cardiovascular risk before initiating. Hypertensive effects may be more pronounced in the elderly and increase the risk for cardiovascular events in those with cardiovascular disease. Avoid use of the drug in any patient with a cerebrovascular syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Migraine | |
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
| 0-9 | A-Z |
|---|---|
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
Formulary Reference Tool