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CYTARABINE (CYTARABINE/PF)
- Acute lymphoid leukemia
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Blastic phase chronic myeloid leukemia
- Meningeal leukemia
20 mg/mL injection solution
- Dosage information is not available
(PF) 100 mg/5 mL (20 mg/mL) injection solution
- Dosage information is not available
(PF) 2 gram/20 mL (100 mg/mL) injection solution
- Dosage information is not available
(PF) 20 mg/mL injection solution
- Dosage information is not available
100 mg/5 mL (20 mg/mL) injection solution
- Dosage information is not available
2 gram/20 mL (100 mg/mL) injection solution
- Dosage information is not available
20 mg/mL injection solution
- Dosage information is not available
Diffuse large b-cell lymphoma
- Infuse 300 mg/m2 by intravenous route once
- Infuse 30 mg/m2 by intrathecal route once
- Infuse 100 mg/m2 by intravenous route every 12 hours
- Infuse 100 mg/m2 by intravenous route every 12 hours for 4 days
- Infuse 2,000 mg/m2 by intravenous route every 12 hours
- Infuse 2,000 mg/m2 by intravenous route once
Progressive diffuse large b-cell lymphoma
- Infuse 300 mg/m2 by intravenous route once
- Infuse 30 mg/m2 by intrathecal route once
- Infuse 100 mg/m2 by intravenous route every 12 hours
- Infuse 100 mg/m2 by intravenous route every 12 hours for 4 days
- Infuse 2,000 mg/m2 by intravenous route every 12 hours
- Infuse 2,000 mg/m2 by intravenous route once
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- Digox
- digoxin
- Lanoxin
- Lactating mother
Contraindicated
- Acute pancreatitis
- Acute respiratory distress syndrome
- Anemia
- Bacterial infection
- Bone marrow depression
- Cardiomyopathy
- Coma
- Disease of liver
- Gastrointestinal ulcer
- Hyperuricemia
- Intestinal ischemic necrosis
- Leukopenia
- Necrotizing enterocolitis
- Opportunistic fungal infection
- Opportunistic viral infection
- Peripheral neuropathy
- Pregnancy
- Protozoal infection
- Pulmonary edema
- Thrombocytopenic disorder
Severe
Moderate
- Diarrhea
- Granulocytopenic disorder
- Kidney disease with likely reduction in GFR
- Stomatitis
- Vomiting
CYTARABINE (CYTARABINE/PF)
- Acute lymphoid leukemia
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Blastic phase chronic myeloid leukemia
- Meningeal leukemia
- Infection
- Leukopenia
- Stomatitis
- Thrombocytopenic disorder
- Anorexia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- CNS toxicity
- Hyperuricemia
- Paresthesia
- Uric acid nephropathy
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Bone pain
- Chest pain
- Drug-induced hepatitis
- Esophagitis
- Fever
- Gastrointestinal hemorrhage
- Injection site sequelae
- Interstitial pneumonitis
- Jaundice
- Malaise
- Megaloblastic anemia
- Myalgias
- Pancreatitis
- Pulmonary edema
- Skin rash
- Thrombophlebitis
- Urinary retention
Less Severe
- Alopecia
- Diarrhea
- Dizziness
- Dyschromia
- Headache disorder
- Pruritus of skin
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Cytarabine
- Severity Level:
D
- Additional Notes:
Contraindicated
Cytarabine
Potential severe adverse effects including bone marrow depression.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential severe adverse effects including bone marrow depression. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Cytarabine
General-May need to reduce dose.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- This medication may cause serious (rarely fatal) blood disorders (bone marrow suppression leading to anemia, low number of white blood cells and platelets). Liver problems may also occur. Your doctor will monitor you closely for these side effects.<br /><br /> Tell your doctor right away if you develop any signs of infection (e.g., fever, chills, persistent sore throat), unusual fatigue, easy bruising or bleeding, nausea, vomiting, diarrhea, stomach/abdominal pain, dark urine, yellowing eyes/skin, or mouth sores.
| Acute lymphoid leukemia | |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| Acute myeloid leukemia | |
| C92.0 | Acute myeloblastic leukemia |
| C92.00 | Acute myeloblastic leukemia, not having achieved remission |
| C92.02 | Acute myeloblastic leukemia, in relapse |
| C92.4 | Acute promyelocytic leukemia |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| C92.5 | Acute myelomonocytic leukemia |
| C92.50 | Acute myelomonocytic leukemia, not having achieved remission |
| C92.52 | Acute myelomonocytic leukemia, in relapse |
| C92.6 | Acute myeloid leukemia with 11q23-abnormality |
| C92.60 | Acute myeloid leukemia with 11q23-abnormality not having achieved remission |
| C92.62 | Acute myeloid leukemia with 11q23-abnormality in relapse |
| C93.0 | Acute monoblastic/monocytic leukemia |
| C93.00 | Acute monoblastic/monocytic leukemia, not having achieved remission |
| C93.02 | Acute monoblastic/monocytic leukemia, in relapse |
| C94.4 | Acute panmyelosis with myelofibrosis |
| C94.40 | Acute panmyelosis with myelofibrosis not having achieved remission |
| C94.42 | Acute panmyelosis with myelofibrosis, in relapse |
| Acute promyelocytic leukemia | |
| C92.4 | Acute promyelocytic leukemia |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| Blastic phase chronic myeloid leukemia | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.2 | Atypical chronic myeloid leukemia, BCr/ABl-negative |
| C92.20 | Atypical chronic myeloid leukemia, BCr/ABl-negative, not having achieved remission |
| C92.22 | Atypical chronic myeloid leukemia, BCr/ABl-negative, in relapse |
| Meningeal leukemia | |
| C90.1 | Plasma cell leukemia |
| C90.10 | Plasma cell leukemia not having achieved remission |
| C90.12 | Plasma cell leukemia in relapse |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| C91.1 | Chronic lymphocytic leukemia of b-cell type |
| C91.10 | Chronic lymphocytic leukemia of b-cell type not having achieved remission |
| C91.12 | Chronic lymphocytic leukemia of b-cell type in relapse |
| C91.3 | Prolymphocytic leukemia of b-cell type |
| C91.30 | Prolymphocytic leukemia of b-cell type not having achieved remission |
| C91.32 | Prolymphocytic leukemia of b-cell type, in relapse |
| C91.4 | Hairy cell leukemia |
| C91.40 | Hairy cell leukemia not having achieved remission |
| C91.42 | Hairy cell leukemia, in relapse |
| C91.5 | Adult t-cell lymphoma/leukemia (HTLv-1-associated) |
| C91.50 | Adult t-cell lymphoma/leukemia (HTLv-1-associated) not having achieved remission |
| C91.52 | Adult t-cell lymphoma/leukemia (HTLv-1-associated), in relapse |
| C91.6 | Prolymphocytic leukemia of t-cell type |
| C91.60 | Prolymphocytic leukemia of t-cell type not having achieved remission |
| C91.62 | Prolymphocytic leukemia of t-cell type, in relapse |
| C91.9 | Lymphoid leukemia, unspecified |
| C91.90 | Lymphoid leukemia, unspecified not having achieved remission |
| C91.92 | Lymphoid leukemia, unspecified, in relapse |
| C91.A | Mature b-cell leukemia burkitt-type |
| C91.A0 | Mature b-cell leukemia burkitt-type not having achieved remission |
| C91.A2 | Mature b-cell leukemia burkitt-type, in relapse |
| C91.Z | Other lymphoid leukemia |
| C91.Z0 | Other lymphoid leukemia not having achieved remission |
| C91.Z2 | Other lymphoid leukemia, in relapse |
| C92.0 | Acute myeloblastic leukemia |
| C92.00 | Acute myeloblastic leukemia, not having achieved remission |
| C92.02 | Acute myeloblastic leukemia, in relapse |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.2 | Atypical chronic myeloid leukemia, BCr/ABl-negative |
| C92.20 | Atypical chronic myeloid leukemia, BCr/ABl-negative, not having achieved remission |
| C92.22 | Atypical chronic myeloid leukemia, BCr/ABl-negative, in relapse |
| C92.4 | Acute promyelocytic leukemia |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| C92.5 | Acute myelomonocytic leukemia |
| C92.50 | Acute myelomonocytic leukemia, not having achieved remission |
| C92.52 | Acute myelomonocytic leukemia, in relapse |
| C92.6 | Acute myeloid leukemia with 11q23-abnormality |
| C92.60 | Acute myeloid leukemia with 11q23-abnormality not having achieved remission |
| C92.62 | Acute myeloid leukemia with 11q23-abnormality in relapse |
| C92.9 | Myeloid leukemia, unspecified |
| C92.90 | Myeloid leukemia, unspecified, not having achieved remission |
| C92.92 | Myeloid leukemia, unspecified in relapse |
| C92.A | Acute myeloid leukemia with multilineage dysplasia |
| C92.A0 | Acute myeloid leukemia with multilineage dysplasia, not having achieved remission |
| C92.A2 | Acute myeloid leukemia with multilineage dysplasia, in relapse |
| C92.Z | Other myeloid leukemia |
| C92.Z0 | Other myeloid leukemia not having achieved remission |
| C92.Z2 | Other myeloid leukemia, in relapse |
| C93.0 | Acute monoblastic/monocytic leukemia |
| C93.00 | Acute monoblastic/monocytic leukemia, not having achieved remission |
| C93.02 | Acute monoblastic/monocytic leukemia, in relapse |
| C93.1 | Chronic myelomonocytic leukemia |
| C93.10 | Chronic myelomonocytic leukemia not having achieved remission |
| C93.12 | Chronic myelomonocytic leukemia, in relapse |
| C93.3 | Juvenile myelomonocytic leukemia |
| C93.30 | Juvenile myelomonocytic leukemia, not having achieved remission |
| C93.32 | Juvenile myelomonocytic leukemia, in relapse |
| C93.9 | Monocytic leukemia, unspecified |
| C93.90 | Monocytic leukemia, unspecified, not having achieved remission |
| C93.92 | Monocytic leukemia, unspecified in relapse |
| C93.Z | Other monocytic leukemia |
| C93.Z0 | Other monocytic leukemia, not having achieved remission |
| C93.Z2 | Other monocytic leukemia, in relapse |
| C94.0 | Acute erythroid leukemia |
| C94.00 | Acute erythroid leukemia, not having achieved remission |
| C94.02 | Acute erythroid leukemia, in relapse |
| C94.2 | Acute megakaryoblastic leukemia |
| C94.20 | Acute megakaryoblastic leukemia not having achieved remission |
| C94.22 | Acute megakaryoblastic leukemia, in relapse |
| C94.3 | Mast cell leukemia |
| C94.30 | Mast cell leukemia not having achieved remission |
| C94.32 | Mast cell leukemia, in relapse |
| C94.8 | Other specified leukemias |
| C94.80 | Other specified leukemias not having achieved remission |
| C94.82 | Other specified leukemias, in relapse |
| C95.0 | Acute leukemia of unspecified cell type |
| C95.00 | Acute leukemia of unspecified cell type not having achieved remission |
| C95.02 | Acute leukemia of unspecified cell type, in relapse |
| C95.1 | Chronic leukemia of unspecified cell type |
| C95.10 | Chronic leukemia of unspecified cell type not having achieved remission |
| C95.12 | Chronic leukemia of unspecified cell type, in relapse |
| C95.9 | Leukemia, unspecified |
| C95.90 | Leukemia, unspecified not having achieved remission |
| C95.92 | Leukemia, unspecified, in relapse |
| 0-9 | A-Z |
|---|---|
| C90.1 | Plasma cell leukemia |
| C90.10 | Plasma cell leukemia not having achieved remission |
| C90.12 | Plasma cell leukemia in relapse |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| C91.1 | Chronic lymphocytic leukemia of b-cell type |
| C91.10 | Chronic lymphocytic leukemia of b-cell type not having achieved remission |
| C91.12 | Chronic lymphocytic leukemia of b-cell type in relapse |
| C91.3 | Prolymphocytic leukemia of b-cell type |
| C91.30 | Prolymphocytic leukemia of b-cell type not having achieved remission |
| C91.32 | Prolymphocytic leukemia of b-cell type, in relapse |
| C91.4 | Hairy cell leukemia |
| C91.40 | Hairy cell leukemia not having achieved remission |
| C91.42 | Hairy cell leukemia, in relapse |
| C91.5 | Adult t-cell lymphoma/leukemia (HTLv-1-associated) |
| C91.50 | Adult t-cell lymphoma/leukemia (HTLv-1-associated) not having achieved remission |
| C91.52 | Adult t-cell lymphoma/leukemia (HTLv-1-associated), in relapse |
| C91.6 | Prolymphocytic leukemia of t-cell type |
| C91.60 | Prolymphocytic leukemia of t-cell type not having achieved remission |
| C91.62 | Prolymphocytic leukemia of t-cell type, in relapse |
| C91.9 | Lymphoid leukemia, unspecified |
| C91.90 | Lymphoid leukemia, unspecified not having achieved remission |
| C91.92 | Lymphoid leukemia, unspecified, in relapse |
| C91.A | Mature b-cell leukemia burkitt-type |
| C91.A0 | Mature b-cell leukemia burkitt-type not having achieved remission |
| C91.A2 | Mature b-cell leukemia burkitt-type, in relapse |
| C91.Z | Other lymphoid leukemia |
| C91.Z0 | Other lymphoid leukemia not having achieved remission |
| C91.Z2 | Other lymphoid leukemia, in relapse |
| C92.0 | Acute myeloblastic leukemia |
| C92.0 | Acute myeloblastic leukemia |
| C92.00 | Acute myeloblastic leukemia, not having achieved remission |
| C92.00 | Acute myeloblastic leukemia, not having achieved remission |
| C92.02 | Acute myeloblastic leukemia, in relapse |
| C92.02 | Acute myeloblastic leukemia, in relapse |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.2 | Atypical chronic myeloid leukemia, BCr/ABl-negative |
| C92.2 | Atypical chronic myeloid leukemia, BCr/ABl-negative |
| C92.20 | Atypical chronic myeloid leukemia, BCr/ABl-negative, not having achieved remission |
| C92.20 | Atypical chronic myeloid leukemia, BCr/ABl-negative, not having achieved remission |
| C92.22 | Atypical chronic myeloid leukemia, BCr/ABl-negative, in relapse |
| C92.22 | Atypical chronic myeloid leukemia, BCr/ABl-negative, in relapse |
| C92.4 | Acute promyelocytic leukemia |
| C92.4 | Acute promyelocytic leukemia |
| C92.4 | Acute promyelocytic leukemia |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.40 | Acute promyelocytic leukemia, not having achieved remission |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| C92.42 | Acute promyelocytic leukemia, in relapse |
| C92.5 | Acute myelomonocytic leukemia |
| C92.5 | Acute myelomonocytic leukemia |
| C92.50 | Acute myelomonocytic leukemia, not having achieved remission |
| C92.50 | Acute myelomonocytic leukemia, not having achieved remission |
| C92.52 | Acute myelomonocytic leukemia, in relapse |
| C92.52 | Acute myelomonocytic leukemia, in relapse |
| C92.6 | Acute myeloid leukemia with 11q23-abnormality |
| C92.6 | Acute myeloid leukemia with 11q23-abnormality |
| C92.60 | Acute myeloid leukemia with 11q23-abnormality not having achieved remission |
| C92.60 | Acute myeloid leukemia with 11q23-abnormality not having achieved remission |
| C92.62 | Acute myeloid leukemia with 11q23-abnormality in relapse |
| C92.62 | Acute myeloid leukemia with 11q23-abnormality in relapse |
| C92.9 | Myeloid leukemia, unspecified |
| C92.90 | Myeloid leukemia, unspecified, not having achieved remission |
| C92.92 | Myeloid leukemia, unspecified in relapse |
| C92.A | Acute myeloid leukemia with multilineage dysplasia |
| C92.A0 | Acute myeloid leukemia with multilineage dysplasia, not having achieved remission |
| C92.A2 | Acute myeloid leukemia with multilineage dysplasia, in relapse |
| C92.Z | Other myeloid leukemia |
| C92.Z0 | Other myeloid leukemia not having achieved remission |
| C92.Z2 | Other myeloid leukemia, in relapse |
| C93.0 | Acute monoblastic/monocytic leukemia |
| C93.0 | Acute monoblastic/monocytic leukemia |
| C93.00 | Acute monoblastic/monocytic leukemia, not having achieved remission |
| C93.00 | Acute monoblastic/monocytic leukemia, not having achieved remission |
| C93.02 | Acute monoblastic/monocytic leukemia, in relapse |
| C93.02 | Acute monoblastic/monocytic leukemia, in relapse |
| C93.1 | Chronic myelomonocytic leukemia |
| C93.10 | Chronic myelomonocytic leukemia not having achieved remission |
| C93.12 | Chronic myelomonocytic leukemia, in relapse |
| C93.3 | Juvenile myelomonocytic leukemia |
| C93.30 | Juvenile myelomonocytic leukemia, not having achieved remission |
| C93.32 | Juvenile myelomonocytic leukemia, in relapse |
| C93.9 | Monocytic leukemia, unspecified |
| C93.90 | Monocytic leukemia, unspecified, not having achieved remission |
| C93.92 | Monocytic leukemia, unspecified in relapse |
| C93.Z | Other monocytic leukemia |
| C93.Z0 | Other monocytic leukemia, not having achieved remission |
| C93.Z2 | Other monocytic leukemia, in relapse |
| C94.0 | Acute erythroid leukemia |
| C94.00 | Acute erythroid leukemia, not having achieved remission |
| C94.02 | Acute erythroid leukemia, in relapse |
| C94.2 | Acute megakaryoblastic leukemia |
| C94.20 | Acute megakaryoblastic leukemia not having achieved remission |
| C94.22 | Acute megakaryoblastic leukemia, in relapse |
| C94.3 | Mast cell leukemia |
| C94.30 | Mast cell leukemia not having achieved remission |
| C94.32 | Mast cell leukemia, in relapse |
| C94.4 | Acute panmyelosis with myelofibrosis |
| C94.40 | Acute panmyelosis with myelofibrosis not having achieved remission |
| C94.42 | Acute panmyelosis with myelofibrosis, in relapse |
| C94.8 | Other specified leukemias |
| C94.80 | Other specified leukemias not having achieved remission |
| C94.82 | Other specified leukemias, in relapse |
| C95.0 | Acute leukemia of unspecified cell type |
| C95.00 | Acute leukemia of unspecified cell type not having achieved remission |
| C95.02 | Acute leukemia of unspecified cell type, in relapse |
| C95.1 | Chronic leukemia of unspecified cell type |
| C95.10 | Chronic leukemia of unspecified cell type not having achieved remission |
| C95.12 | Chronic leukemia of unspecified cell type, in relapse |
| C95.9 | Leukemia, unspecified |
| C95.90 | Leukemia, unspecified not having achieved remission |
| C95.92 | Leukemia, unspecified, in relapse |
Formulary Reference Tool