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TEPEZZA (teprotumumab-trbw)
- Graves' eye disease
500 mg intravenous solution
- Infuse 20 mg/kg over 60-90 minute(s) by intravenous route every 3 weeks
Thyroid eye disease
- Infuse 20 mg/kg over 60-90 minute(s) by intravenous route every 3 weeks
- Infuse 10 mg/kg over 90 minute(s) by intravenous route once
- Infuse 20 mg/kg over 60-90 minute(s) by intravenous route every 3 weeks for 7 doses
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Inflammatory bowel disease
- Pregnancy
Severe
Moderate
- Diabetes mellitus
TEPEZZA (teprotumumab-trbw)
- Graves' eye disease
- None
- Alopecia
- Diarrhea
- Dry skin
- Dysgeusia
- Fatigue
- Headache disorder
- Hearing loss
- Hyperglycemia
- Muscle spasm
- Nausea
More Frequent
Severe
Less Severe
- Hypertension
- Abnormal vaginal bleeding
- Amenorrhea
- Dysmenorrhea
- Dyspnea
- Myalgia
- Sensation of warmth
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Diabetic ketoacidosis
- Hyperosmolar hyperglycemic state
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Teprotumumab-trbw
Safety and effectiveness not established in pediatric patients.
- 1 Day – 18 Years
- Safety and effectiveness not established in pediatric patients.
Teprotumumab-trbw
- Severity Level:
D
- Additional Notes: Based on drug pharmacology, dev tox possible; mfr does not recommend during preg
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Teprotumumab-trbw
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Thyroid eye disease | |
| E05.00 | Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm |
| 0-9 | A-Z |
|---|---|
| E05.00 | Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm |
Formulary Reference Tool