PROMETHAZINE-PHENYLEPHRINE (PHENYLEPHRINE HCL/PROMETHAZINE HCL)
- Allergic rhinitis
- Cold symptoms
- Nasal congestion
- Allergic conjunctivitis
- Perennial allergic rhinitis
- Rhinorrhea
- Seasonal allergic rhinitis
- Sneezing
- Vasomotor rhinitis
6.25 mg-5 mg/5 mL oral syrup
- 5 milliliters by oral route every 6 hours as needed
6.25 mg-5 mg/5 mL oral syrup
- 5 milliliters by oral route every 6 hours as needed
Nasal congestion
- 5 milliliters by oral route every 4 hours as needed
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed
Sneezing
- 5 milliliters by oral route every 4 hours as needed
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Orap
- Parnate
- phenelzine
- pimozide
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- Compound 347
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- isoflurane
- linezolid
- methylergonovine
- Migergot
- Migranal
- Parlodel
- rasagiline
- selegiline HCl
- sevoflurane
- sodium oxybate
- Sojourn
- Terrell
- Ultane
- Xyrem
- Zelapar
- Zyvox
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- codeine-butalbital-ASA-caff
- Cogentin
- Cuvposa
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Enlon-plus
- Esgic
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- propantheline
- Prosed/ds (atropine Free)
- reserpine
- Respa-ar
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Acute myocardial infarction
- Arterial thrombosis
- Coma
- Congenital long QT syndrome
- Neuroleptic malignant syndrome
- Severe uncontrolled hypertension
- Torsades de pointes
- Ventricular tachycardia
Contraindicated
- Acute hepatitis
- Acute pancreatitis
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Bradycardia
- Chronic idiopathic constipation
- Chronic obstructive pulmonary disease
- Coronary artery disease
- Hypertension
- Hyperthyroidism
- Incomplete AV heart block
- Parkinsonism
- Prolonged QT interval
- Pyloroduodenal obstruction
- Respiratory depression
- Severe arteriosclerotic vascular disease
- Sleep apnea
- Stenosing peptic ulcer
Severe
Moderate
- Acidosis
- Bone marrow depression
- Chronic heart failure
- Disease of liver
- Gastrointestinal obstruction
- Hyperbilirubinemia
- Hypoxia
- Lower seizure threshold
- Seizure disorder
PROMETHAZINE-PHENYLEPHRINE (PHENYLEPHRINE HCL/PROMETHAZINE HCL)
- Allergic rhinitis
- Cold symptoms
- Nasal congestion
- Allergic conjunctivitis
- Perennial allergic rhinitis
- Rhinorrhea
- Seasonal allergic rhinitis
- Sneezing
- Vasomotor rhinitis
- Hypotension
- Tachycardia
- Acute confusion
- Blurred vision
- Dizziness
- Drowsy
- Excitement
- Irritability
- Nervousness
- Nightmares
- Skin photosensitivity
- Skin rash
- Thick bronchial secretions
- Tinnitus
- Visual changes
- Xerostomia
More Frequent
Severe
Less Severe
- Sedation
- Hyperhidrosis
- Nasal congestion
- Syncope
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Angioedema
- Apnea
- Asthma
- Bradycardia
- Cardiac arrhythmia
- Delirium
- Dissociative disorder
- Dizziness
- Extrapyramidal disease
- Hallucinations
- Headache disorder
- Hyperhidrosis
- Hypertension
- Insomnia
- Jaundice
- Leukopenia
- Lower seizure threshold
- Nervousness
- Neuroleptic malignant syndrome
- Obstructive hyperbilirubinemia
- Pallor
- Respiratory depression
- Seizure disorder
- Tachycardia
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Tremor
- Urticaria
Less Severe
- Anorexia
- Ataxia
- Diplopia
- Dysuria
- Euphoria
- Fatigue
- Insomnia
- Nausea
- Skin inflammation
- Tremor
- Vomiting
Contraindicated
Phenylephrine (Oral,Rectal)
Risk of CNS excitation. Do not use age <6 years without clinician consult.
Potential for fatal respiratory depression age < 2 years. Avoid use.
- 1 Day – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 2 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
Promethazine
Risk of CNS excitation. Do not use age <6 years without clinician consult.
Potential for fatal respiratory depression age < 2 years. Avoid use.
- 1 Day – 6 Years
- 1 Potential for fatal respiratory depression age < 2 years. Avoid use.
- 1 Day – 2 Years
- 1 Potential for fatal respiratory depression age < 2 years. Avoid use.
Severe Precaution
Promethazine
Caution:use the lowest effective dose due to risk of respiratory depression.
- 2 Years – 18 Years
- Caution:use the lowest effective dose due to risk of respiratory depression.
Management or Monitoring Precaution
None
Phenylephrine
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Promethazine Hydrochloride
- Severity Level:
C
- Additional Notes: Caution with use; risk of platelet aggregation in newborn
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Phenylephrine
Oral bioavailability low; infant exposure may be minimal
Limited amount may be excreted due to low mw; monitor infant for resp depress
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Oral bioavailability low; infant exposure may be minimal |
Promethazine
Oral bioavailability low; infant exposure may be minimal
Limited amount may be excreted due to low mw; monitor infant for resp depress
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Limited amount may be excreted due to low mw; monitor infant for resp depress |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (including some long-acting tablets/capsules) are not recommended for use in children younger than 12 years.<br /><br />Do not use this product to make a child sleepy. This product is not recommended for use in children younger than 2 years since it might cause serious (possibly fatal) slow/shallow breathing. In children 2 years and older, carefully follow the doctor's directions to use the lowest effective dose.<br /><br /> Do not give more often than prescribed. Talk to the doctor or pharmacist before giving other cough-and-cold medication that might contain the same or similar ingredients that might also affect breathing. Get immediate medical help if you notice unusual slow/shallow breathing.
Allergic conjunctivitis | |
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
Allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
Cold symptoms | |
J00 | Acute nasopharyngitis [common cold] |
Nasal congestion | |
R09.81 | Nasal congestion |
Perennial allergic rhinitis | |
J31.0 | Chronic rhinitis |
Rhinorrhea | |
R09.82 | Postnasal drip |
Seasonal allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
Sneezing | |
R06.7 | Sneezing |
Vasomotor rhinitis | |
J30.0 | Vasomotor rhinitis |
0-9 | A-Z |
---|---|
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
J00 | Acute nasopharyngitis [common cold] |
J30.0 | Vasomotor rhinitis |
J30.1 | Allergic rhinitis due to pollen |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
J31.0 | Chronic rhinitis |
R06.7 | Sneezing |
R09.81 | Nasal congestion |
R09.82 | Postnasal drip |