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AKYNZEO (NETUPITANT/PALONOSETRON HCL)
- Prevention of chemotherapy-induced nausea and vomiting
- Akynzeo Capsule
- Akynzeo (netupitant) Capsule
- Akynzeo (fosnetupitant) Intravenous Solution
- By Indication
(netupitant) 300 mg-0.5 mg capsule
- 1 capsule by oral route 1 hour prior to chemotherapy
(netupitant) 300 mg-0.5 mg capsule
- 1 capsule by oral route 1 hour prior to chemotherapy
(fosnetupitant) 235 mg-0.25 mg intravenous solution
- Dosage information is not available
Prevention of chemotherapy-induced nausea and vomiting
- 1 capsule by oral route 1 hour prior to chemotherapy
- Juxtapid
- lomitapide
Contraindicated
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Bosulif
- bosutinib
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- colchicine
- colchicine-probenecid
- Colcrys
- Cold & Flu Fighter
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- fosphenytoin
- guanfacine
- ibrutinib
- Imbruvica
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Olysio
- Orap
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Samsca
- simeprevir
- St. John's wort
- Tegretol
- Tegretol Xr
- Tenex
- tolvaptan
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
Severe
Moderate
- Abstral
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- alprazolam
- Alprazolam Intensol
- avanafil
- bosentan
- cilostazol
- Conzip
- Duragesic
- Endocet
- Endodan
- eplerenone
- everolimus
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- ibuprofen-oxycodone
- Inspra
- ivacaftor
- Kalydeco
- Latuda
- Lazanda
- Levitra
- lurasidone
- midazolam
- Niravam
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Pletal
- Primlev
- Roxicet
- Stendra
- Sublimaze (pf)
- Subsys
- Synapryn
- Tracleer
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- triazolam
- Ultracet
- Ultram
- Ultram Er
- vardenafil
- Xanax
- Xanax Xr
- Xartemis Xr
- Zortress
- None
Contraindicated
- Serotonin syndrome
Severe
Moderate
- None
AKYNZEO (NETUPITANT/PALONOSETRON HCL)
- Prevention of chemotherapy-induced nausea and vomiting
- None
- Constipation
- Dyspepsia
- Erythema
- Fatigue
- General weakness
- Headache disorder
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Hypersensitivity drug reaction
- Serotonin syndrome
Less Severe
- Abnormal hepatic function tests
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Palonosetron, (fos)netupitant
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Palonosetron- (fos)netupitant
- Severity Level:
2
- Additional Notes: Insufficient human data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Palonosetron-(fos)netupitant
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
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