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SEREVENT DISKUS (SALMETEROL XINAFOATE)
- Adjunct maintenance tx for asthma
- Bronchospasm prevention with COPD
- Prevention of bronchospasm with chronic bronchitis
- Exercise-induced bronchospasm prevention
- Prevention of bronchospasms with emphysema
50 mcg/dose powder for inhalation
- Inhale 1 puff by inhalation route 2 times per day in the morning and evening approximately 12 hours apart
Adjunct maintenance tx for asthma
- Inhale 1 puff by inhalation route 2 times per day in the morning and evening approximately 12 hours apart
- Inhale 1 puff by inhalation route every 12 hours
Bronchospasm prevention with COPD
- Inhale 1 puff by inhalation route 2 times per day in the morning and evening approximately 12 hours apart
Exercise-induced bronchospasm prevention
- Inhale 1 puff by inhalation route at least 30 to 60 minutes before exercise
Prevention of bronchospasms with emphysema
- Inhale 1 puff by inhalation route 2 times per day in the morning and evening approximately 12 hours apart
- Inhale 1 puff by inhalation route every 12 hours
- None
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- amoxicil-clarithromy-lansopraz
- artemether-lumefantrine
- atazanavir
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- bromocriptine
- cabergoline
- Cafergot
- clarithromycin
- Coartem
- Compound 347
- Cordarone
- Crixivan
- Cycloset
- D.h.e.45
- dihydroergotamine
- disopyramide
- dronedarone
- droperidol
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- fosamprenavir
- Geodon
- Incivek
- indinavir
- Invirase
- isoflurane
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lopinavir-ritonavir
- methylergonovine
- Migergot
- Migranal
- Multaq
- nefazodone
- nelfinavir
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Pacerone
- Parlodel
- pimozide
- Prevpac
- Reyataz
- ritonavir
- saquinavir mesylate
- sevoflurane
- Sojourn
- Sporanox
- Sporanox Pulsepak
- telaprevir
- telithromycin
- Terrell
- thioridazine
- Ultane
- Victrelis
- Viracept
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- alfuzosin
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Caprelsa
- Celexa
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- clozapine
- Clozaril
- Complera
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- emtricitab-rilpivirine-tenofov
- eribulin
- escitalopram oxalate
- ezogabine
- Fareston
- Fazaclo
- gadofosveset trisodium
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- Istodax
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nexavar
- nilotinib
- norfloxacin
- Noroxin
- Noxafil
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- pasireotide
- pazopanib
- posaconazole
- Potiga
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- romidepsin
- Rythmol
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- toremifene
- Trisenox
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- Versacloz
- Vibativ
- Votrient
- Xalkori
- Xenazine
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Acutely deteriorating asthma
Contraindicated
- Cardiac arrhythmia
- Chronic myocardial ischemia
- Congenital long QT syndrome
- Hypokalemia
- Prolonged QT interval
Severe
Moderate
- Diabetes mellitus
- Hypertension
- Seizure disorder
- Thyrotoxicosis
SEREVENT DISKUS (SALMETEROL XINAFOATE)
- Adjunct maintenance tx for asthma
- Bronchospasm prevention with COPD
- Prevention of bronchospasm with chronic bronchitis
- Exercise-induced bronchospasm prevention
- Prevention of bronchospasms with emphysema
- None
- Headache disorder
More Frequent
Severe
Less Severe
- None
- Cough
- Cramps
- Dizziness
- Influenza
- Nasal congestion
- Nausea
- Nervousness
- Palpitations
- Rhinitis
- Sore throat
- Tachycardia
- Tremor
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angina
- Angioedema
- Asthma exacerbation
- Atrial fibrillation
- Bronchitis
- Cardiac arrhythmia
- Chest pain
- Conjunctivitis
- Edema
- Extrasystoles
- Hyperglycemia
- Hypersensitivity drug reaction
- Hypertension
- Hypotension
- Keratitis
- Laryngismus
- Paradoxical bronchospasm
- Prolonged QT interval
- Seizure disorder
- Sinusitis
- Stridor
- Upper respiratory infection
- Ventricular tachycardia
Less Severe
- Arthralgias
- Contact dermatitis
- Dyspepsia
- Earache
- Eczema
- Fatigue
- Fever
- Insomnia
- Laryngitis
- Malaise
- Myalgias
- Oral candidiasis
- Paresthesia
- Skin rash
- Symptoms of anxiety
- Toothache
- Urticaria
- Vomiting
Contraindicated
None
Severe Precaution
Salmeterol
Safety & efficacy not established age <4 years. Not for use in acute asthma attack.
- 1 Day – 4 Years
- Safety & efficacy not established age <4 years. Not for use in acute asthma attack.
Management or Monitoring Precaution
Salmeterol
Fixed-dose combination product with glucocorticoid recommended for treatment of asthma. Do not use for acute asthma.
- 4 Years – 18 Years
- Fixed-dose combination product with glucocorticoid recommended for treatment of asthma. Do not use for acute asthma.
Salmeterol
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Salmeterol
Insufficient human studies data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human studies data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Salmeterol
Cardiovascular-Use caution in severe cardiovascular diseases, particularly coronary insufficiency, since beta-agonists increase heart rate and blood pressure. Endocrine-Use caution in poorly controlled hyperthyroidism or diabetes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | Y |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Rarely, when treating asthma, serious (sometimes fatal) asthma-related breathing problems have occurred with the use of long-acting inhaled beta agonists (such as salmeterol). Therefore, in patients with asthma, this drug should only be prescribed when one long-term medication (such as inhaled corticosteroids) does not control breathing problems or when more than one long-term medication is clearly needed to control breathing problems. Salmeterol must not be used alone to treat asthma.<br /><br />Before using this medication, it is important to learn how to use it properly. Discuss the risks and benefits of treatment with this medication with your doctor. Once asthma symptoms are controlled, if possible, your doctor may stop treatment with salmeterol and continue only your other asthma medications (such as inhaled corticosteroids). Follow your doctor's directions carefully.
| Adjunct maintenance tx for asthma | |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.909 | Unspecified asthma, uncomplicated |
| J45.991 | Cough variant asthma |
| J45.998 | Other asthma |
| Bronchospasm prevention with COPD | |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| Exercise-induced bronchospasm prevention | |
| J45.990 | Exercise induced bronchospasm |
| Prevention of bronchospasm with chronic bronchitis | |
| J41 | Simple and mucopurulent chronic bronchitis |
| J41.0 | Simple chronic bronchitis |
| J41.1 | Mucopurulent chronic bronchitis |
| J41.8 | Mixed simple and mucopurulent chronic bronchitis |
| J42 | Unspecified chronic bronchitis |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| Prevention of bronchospasms with emphysema | |
| J43 | Emphysema |
| J43.0 | Unilateral pulmonary emphysema [macleod's syndrome] |
| J43.1 | Panlobular emphysema |
| J43.2 | Centrilobular emphysema |
| J43.8 | Other emphysema |
| J43.9 | Emphysema, unspecified |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| 0-9 | A-Z |
|---|---|
| J41 | Simple and mucopurulent chronic bronchitis |
| J41.0 | Simple chronic bronchitis |
| J41.1 | Mucopurulent chronic bronchitis |
| J41.8 | Mixed simple and mucopurulent chronic bronchitis |
| J42 | Unspecified chronic bronchitis |
| J43 | Emphysema |
| J43.0 | Unilateral pulmonary emphysema [macleod's syndrome] |
| J43.1 | Panlobular emphysema |
| J43.2 | Centrilobular emphysema |
| J43.8 | Other emphysema |
| J43.9 | Emphysema, unspecified |
| J44 | Other chronic obstructive pulmonary disease |
| J44 | Other chronic obstructive pulmonary disease |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.909 | Unspecified asthma, uncomplicated |
| J45.990 | Exercise induced bronchospasm |
| J45.991 | Cough variant asthma |
| J45.998 | Other asthma |
Formulary Reference Tool