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MYLERAN (BUSULFAN)
- Chronic phase philadelphia chromosome (+) CML
- Conditioning prior to allogeneic stem cell transplant
2 mg tablet
- 1 tablet (2 mg) by oral route once daily
2 mg tablet
- 1 tablet (2 mg) by oral route once daily
Chronic phase philadelphia chromosome (+) CML
- one-half tablet (1 mg) by oral route once daily
- 1 tablet (2 mg) by oral route once weekly
- 1 tablet (2 mg) by oral route once daily
- 2 tablets (4 mg) by oral route once daily
Conditioning prior to allogeneic stem cell transplant
- 1 mg/kg by oral route every 6 hours for 4 days
- 0.44 mg/kg by oral route every 6 hours for 4 days
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Flagyl
- Flagyl Er
- Metro I.v.
- Metrogel Vaginal
- metronidazole
- metronidazole in NaCl (iso-os)
- Vandazole
- Versacloz
Severe
Moderate
- itraconazole
- ketoconazole
- Onmel
- Sporanox
- Sporanox Pulsepak
- Tabloid
- thioguanine
- Lactating mother
Contraindicated
- Anemia
- Hepatic veno-occlusive disease
- Neutropenic disorder
- Pregnancy
- Pulmonary fibrosis
- Severe bone marrow depression
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- Fanconi's anemia
- Hyperglycemia
- Hypokalemia
- Hypomagnesemia
- Seizure disorder
MYLERAN (BUSULFAN)
- Chronic phase philadelphia chromosome (+) CML
- Conditioning prior to allogeneic stem cell transplant
- Anemia
- Infection
- Leukopenia
- Thrombocytopenic disorder
- Amenorrhea
- Female hypogonadism
- Skin thickening
More Frequent
Severe
Less Severe
- Hyperuricemia
- Pulmonary fibrosis
- Stomatitis
- Uric acid nephropathy
- Acute confusion
- Anorexia
- Diarrhea
- General weakness
- Hypotension
- Nausea
- Skin pigmentation enhancement
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Aplastic anemia
- Cataracts
- Corneal dystrophy
- Hepatic veno-occlusive disease
- Hepatocellular damage
- Hyperbilirubinemia
- Neuromuscular blockade
- Obstructive hyperbilirubinemia
- Pancytopenia
- Pneumonia
- Seizure disorder
Less Severe
- Alopecia
- Cheilosis
- Dry skin
- Fatigue
- Gynecomastia
- Skin rash
- Xerostomia
Contraindicated
None
Severe Precaution
Busulfan
Monitor for development of cardiac tamponade. Risk of pneumonia with capillary leak syndrome or veno-occlusive disease.
- 1 Day – 18 Years
- Monitor for development of cardiac tamponade. Risk of pneumonia with capillary leak syndrome or veno-occlusive disease.
Management or Monitoring Precaution
None
Busulfan
- Severity Level:
D
- Additional Notes: Limited human data suggest teratogenicity with 1st trimester exposure
Contraindicated
Busulfan
Insuff human data; potential for serious adv outcomes based on pharmacology
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data; potential for serious adv outcomes based on pharmacology |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This medication decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause you to bruise or bleed more easily. Tell your doctor right away if you develop any of the following symptoms: signs of an infection (such as fever, chills, persistent sore throat), easy bruising/bleeding, pale skin, unusual tiredness.<br /><br /> Your doctor will monitor you closely while you are taking this medication. Keep all medical and laboratory appointments.
| Chronic phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| 0-9 | A-Z |
|---|---|
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
Formulary Reference Tool