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MALARONE (ATOVAQUONE/PROGUANIL HCL)
- Chloro-resistant falciparum malaria prevention
- Plasmodium falciparum malaria
- Plasmodium falciparum malaria prevention
250 mg-100 mg tablet
- 1 tablet by oral route once daily
Pediatric 62.5 mg-25 mg tablet
- 4 tablets by oral route once daily
atovaquone 250 mg-proguanil 100 mg tablet
- 1 tablet by oral route once daily
atovaquone-proguanil (pediatric) 62.5 mg-25 mg tablet
- 4 tablets by oral route once daily
Chloro-resistant falciparum malaria prevention
- 1 tablet by oral route once daily
- 4 tablets by oral route once daily
Plasmodium falciparum malaria
- 4 tablets by oral route once daily for 3 days
Plasmodium falciparum malaria prevention
- 1 tablet by oral route once daily
Plasmodium vivax malaria prevention
- 1 tablet by oral route once daily
- 4 tablets by oral route once daily
- artemether-lumefantrine
- Coartem
- Cuprimine
- Depen Titratabs
- penicillamine
Contraindicated
- First-mary's Mouthwash
- metoclopramide HCl
- Metozolv Odt
- nystatin-TCN-HC-diphenhydramin
- Reglan
- tetracycline
Severe
Moderate
- isoniazid-rifamp-pyrazinamide
- Mycobutin
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Severe renal impairment
Contraindicated
- Disease of liver
- Hemolytic anemia from PK and g6PD deficiencies
- Malabsorption states
Severe
Moderate
- Severe hepatic disease
MALARONE (ATOVAQUONE/PROGUANIL HCL)
- Chloro-resistant falciparum malaria prevention
- Plasmodium falciparum malaria
- Plasmodium falciparum malaria prevention
- None
- Abdominal pain with cramps
- Cough
- Diarrhea
- General weakness
- Headache disorder
- Myalgias
- Nausea
- Pruritus of skin
- Vomiting
More Frequent
Severe
Less Severe
- None
- Anorexia
- Aphthous stomatitis
- Dizziness
- Dyspepsia
- Gastritis
- Visual changes
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Erythema multiforme
- Hepatitis
- Hypersensitivity angiitis
- Stevens-johnson syndrome
- Urticaria
Less Severe
- Back pain
- Fever
- Flu-like symptoms
- Insomnia
- Neutropenic disorder
- Skin photosensitivity
- Skin rash
- Stomatitis
- Upper respiratory infection
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Atovaquone_Proguanil
Safety and efficacy not established for weight < 5kg.
- 1 Day – 119 Days
- Safety and efficacy not established for weight < 5kg.
Atovaquone-proguanil
- Severity Level:
2
- Additional Notes: Insufficient data available; consider maternal benefit vs potential fetal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Atovaquone
Insufficient data available
Caution should be exercised;Cdc does not rec if nursing infant weighs < 11 kg
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Proguanil
Insufficient data available
Caution should be exercised;Cdc does not rec if nursing infant weighs < 11 kg
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Caution should be exercised;Cdc does not rec if nursing infant weighs < 11 kg |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Plasmodium falciparum malaria | |
| B50 | Plasmodium falciparum malaria |
| B50.0 | Plasmodium falciparum malaria with cerebral complications |
| B50.8 | Other severe and complicated plasmodium falciparum malaria |
| B50.9 | Plasmodium falciparum malaria, unspecified |
| P37.3 | Congenital falciparum malaria |
| 0-9 | A-Z |
|---|---|
| B50 | Plasmodium falciparum malaria |
| B50.0 | Plasmodium falciparum malaria with cerebral complications |
| B50.8 | Other severe and complicated plasmodium falciparum malaria |
| B50.9 | Plasmodium falciparum malaria, unspecified |
| P37.3 | Congenital falciparum malaria |
Formulary Reference Tool