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COREG (CARVEDILOL)
- Chronic heart failure
- Hypertension
- Left ventricular dysfunction following MI
12.5 mg tablet
- 1 tablet (12.5 mg) by oral route 2 times per day with food
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day with food
3.125 mg tablet
- 1 tablet (3.125 mg) by oral route 2 times per day with food
6.25 mg tablet
- 1 tablet (6.25 mg) by oral route 2 times per day with food
12.5 mg tablet
- 1 tablet (12.5 mg) by oral route 2 times per day with food
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day with food
3.125 mg tablet
- 1 tablet (3.125 mg) by oral route 2 times per day with food
6.25 mg tablet
- 1 tablet (6.25 mg) by oral route 2 times per day with food
Chronic heart failure
- 1 tablet (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route every 12 hours with food
- 1 tablet (25 mg) by oral route every 12 hours with food
- 2 tablets (12.5 mg) by oral route 2 times per day with food
- 2 tablets (12.5 mg) by oral route every 12 hours with food
- 1 tablet (12.5 mg) by oral route 2 times per day with food
- 1 tablet (12.5 mg) by oral route every 12 hours with food
- 1 tablet (3.125 mg) by oral route 2 times per day with food
- 1 tablet (3.125 mg) by oral route every 12 hours with food
- 2 tablets (6.25 mg) by oral route 2 times per day with food
- 2 tablets (6.25 mg) by oral route every 12 hours with food
- 1 tablet (6.25 mg) by oral route 2 times per day with food
- 1 tablet (6.25 mg) by oral route every 12 hours with food
Hypertension
- 1 tablet (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route every 12 hours with food
- 1 tablet (25 mg) by oral route every 12 hours with food
- 2 tablets (12.5 mg) by oral route 2 times per day with food
- 2 tablets (12.5 mg) by oral route every 12 hours with food
- 1 tablet (12.5 mg) by oral route 2 times per day with food
- 1 tablet (12.5 mg) by oral route every 12 hours with food
- 2 tablets (6.25 mg) by oral route 2 times per day with food
- 2 tablets (6.25 mg) by oral route every 12 hours with food
- 1 tablet (6.25 mg) by oral route 2 times per day with food
- 1 tablet (6.25 mg) by oral route every 12 hours with food
Left ventricular dysfunction following MI
- 1 tablet (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route 2 times per day with food
- 2 tablets (12.5 mg) by oral route 2 times per day with food
- 1 tablet (12.5 mg) by oral route 2 times per day with food
- None
Contraindicated
- Adrenaclick
- Adrenalin
- Asthmanefrin Refill
- Asthmanefrin Starter Kit
- Auvi-q
- Bronchial Mist
- Bronchial Mist Refill
- bupivacaine-epinephrine
- bupivacaine-epinephrine (PF)
- bupivacaine-epinephrine bitart
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- Corlopam
- Duraclon (pf)
- epinephrine
- epinephrine (PF)
- epinephrine base (refill)
- epinephrine HCl
- Epipen
- Epipen 2-pak
- Epipen Jr
- Epipen Jr 2-pak
- fenoldopam
- fingolimod
- Gilenya
- Hycamtin
- Kapvay
- lidocaine-epinephrine
- lidocaine-epinephrine (PF)
- lidocaine-epinephrine bit
- Marcaine-epinephrine
- Marcaine-epinephrine (pf)
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- racepinephrine
- S2 Racepinephrine
- Sensorcaine-mpf/epinephrine
- Sensorcaine/epinephrine
- topotecan
- Xylocaine-epinephrine
- Xylocaine-mpf/epinephrine
Severe
Moderate
- Adalat Cc
- afatinib
- Afeditab Cr
- Amaryl
- aminophylline
- amiodarone
- amiodarone in dextrose,iso-osm
- Apidra
- Apidra Solostar
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cordarone
- Diabeta
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Duetact
- dyphylline
- Elixophyllin
- Gilotrif
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- isoniazid-rifamp-pyrazinamide
- Lantus
- Lantus Solostar
- Levemir
- Levemir Flexpen
- Lufyllin
- Matzim La
- Multaq
- Mycobutin
- nateglinide
- Nexterone
- Nifedical Xl
- nifedipine
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Pacerone
- pioglitazone-glimepiride
- Priftin
- Procardia
- Procardia Xl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Starlix
- Tarka
- Taztia Xt
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- Tiazac
- tolazamide
- tolbutamide
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Acute decompensated HF requiring IV inotropic therapy
- Asthma
- Cardiogenic shock
- Complete atrioventricular block
- Pregnancy
- Second degree atrioventricular heart block
- Severe hepatic disease
Contraindicated
- Chronic bronchitis
- Chronic obstructive pulmonary disease
- Hypotension
- Pulmonary emphysema
- Sick sinus syndrome
- Sinus bradycardia
Severe
Moderate
- CYp2d6 poor metabolizer
- Diabetes mellitus
- First degree atrioventricular heart block
- Intraoperative floppy iris syndrome
- Peripheral vascular disease
- Prinzmetal angina
COREG (CARVEDILOL)
- Chronic heart failure
- Hypertension
- Left ventricular dysfunction following MI
- Bradycardia
- Chest pain
- Dizziness
- Dyspnea
- Edema
- Hyperglycemia
- Hypotension
- Orthostatic hypotension
- Peripheral edema
- Weight gain
- Back pain
- Diarrhea
- Fatigue
- Paresthesia
More Frequent
Severe
Less Severe
- Anemia
- Anorexia
- Atrioventricular block
- Bloody stools
- Depression
- Disease of liver
- Fever
- Flu-like symptoms
- Hematuria
- Jaundice
- Palpitations
- Pruritus of skin
- Pulmonary edema
- Purpura
- Syncope
- Thrombocytopenic disorder
- Urine discoloration
- Abdominal pain with cramps
- Arthralgias
- Blurred vision
- Cough
- Cramps
- Drowsy
- Erectile dysfunction
- General weakness
- Headache disorder
- Hyperhidrosis
- Hypesthesia
- Insomnia
- Malaise
- Myalgias
- Nausea
- Pharyngitis
- Proteinuria
- Rhinitis
- Vertigo
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angina
- Angioedema
- Aplastic anemia
- Erythema multiforme
- Hypovolemia
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
- Urticaria
- Worsening of chronic heart failure
Less Severe
- Hypercholesterolemia
- Hypertension
- Hyperuricemia
- Urinary incontinence
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Carvedilol
Efficacy not established age < 18 years.
- 1 Day – 18 Years
- Efficacy not established age < 18 years.
Carvedilol
- Severity Level:
1
- Additional Notes: Beta blockers w/isa may cause intrauterine growth restriction
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Carvedilol
Monitor for signs of b-blockade, bradycardia,hypotension
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Monitor for signs of b-blockade, bradycardia,hypotension |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Carvedilol
Cardiovascular-Minimize dose to decrease dizziness and falls. Plasma levels as much as 50% higher in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | N | Y | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Chronic heart failure | |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Left ventricular dysfunction following MI | |
| I23.8 | Other current complications following acute myocardial infarction |
| I50.1 | Left ventricular failure, unspecified |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| I23.8 | Other current complications following acute myocardial infarction |
| I50.1 | Left ventricular failure, unspecified |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
Formulary Reference Tool