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ADVAIR HFA (FLUTICASONE PROPIONATE/SALMETEROL XINAFOATE)
- Maintenance therapy for asthma
115 mcg-21 mcg/actuation aerosol inhaler
- Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
230 mcg-21 mcg/actuation aerosol inhaler
- Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
45 mcg-21 mcg/actuation aerosol inhaler
- Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
Maintenance therapy for asthma
- Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
- natalizumab
- Tysabri
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- amoxicil-clarithromy-lansopraz
- artemether-lumefantrine
- atazanavir
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- bromocriptine
- cabergoline
- Cafergot
- clarithromycin
- Coartem
- Compound 347
- Cordarone
- Crixivan
- Cycloset
- D.h.e.45
- dihydroergotamine
- disopyramide
- dronedarone
- droperidol
- elvitegr-cobicist-emtric-tenof
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- fosamprenavir
- Geodon
- Incivek
- indinavir
- Invirase
- isoflurane
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Korlym
- Lexiva
- lopinavir-ritonavir
- methylergonovine
- Mifeprex
- mifepristone
- Migergot
- Migranal
- Multaq
- nefazodone
- nelfinavir
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Pacerone
- Parlodel
- pimozide
- Prevpac
- Reyataz
- ritonavir
- saquinavir mesylate
- sevoflurane
- Sojourn
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- Terrell
- thioridazine
- Ultane
- Victrelis
- Viracept
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- alfuzosin
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Caprelsa
- Celexa
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- clozapine
- Clozaril
- Complera
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- emtricitab-rilpivirine-tenofov
- eribulin
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- escitalopram oxalate
- ezogabine
- Fareston
- Fazaclo
- gadofosveset trisodium
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- Istodax
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nexavar
- nilotinib
- norfloxacin
- Noroxin
- Noxafil
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- pasireotide
- pazopanib
- posaconazole
- Potiga
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- romidepsin
- Rythmol
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- toremifene
- Trisenox
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- Versacloz
- Vibativ
- Votrient
- Xalkori
- Xenazine
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Acutely deteriorating asthma
Contraindicated
- Active tuberculosis
- Cardiac arrhythmia
- Chronic myocardial ischemia
- Congenital long QT syndrome
- Hypokalemia
- Ocular herpes simplex
- Parasitic infection
- Prolonged QT interval
Severe
Moderate
- Cataracts
- Diabetes mellitus
- Hypertension
- Hypothalamic-pituitary insufficiency
- Open angle glaucoma
- Oral candidiasis
- Osteopenia
- Osteoporosis
- Seizure disorder
- Thyrotoxicosis
ADVAIR HFA (FLUTICASONE PROPIONATE/SALMETEROL XINAFOATE)
- Maintenance therapy for asthma
- Bronchitis
- Cough
- Headache disorder
- Myalgias
- Oral candidiasis
- Pharyngeal candidiasis
- Pharyngitis
- Sinusitis
- Upper respiratory infection
More Frequent
Severe
Less Severe
- None
- Cough
- Cramps
- Dizziness
- Influenza
- Nasal congestion
- Nausea
- Nervousness
- Palpitations
- Rhinitis
- Sore throat
- Tachycardia
- Tremor
- Voice change
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Aggressive behavior
- Anaphylaxis
- Angina
- Angioedema
- Asthma exacerbation
- Atrial fibrillation
- Bronchitis
- Cardiac arrhythmia
- Cataracts
- Central serous chorioretinopathy
- Chest pain
- Conjunctivitis
- Edema
- Esophageal candidiasis
- Extrasystoles
- Glaucoma
- Hypercortisolism
- Hyperglycemia
- Hypersensitivity angiitis
- Hypersensitivity drug reaction
- Hypertension
- Hypotension
- Immunosuppression
- Keratitis
- Laryngismus
- Osteopenia
- Osteoporosis
- Paradoxical bronchospasm
- Pneumonia
- Prolonged QT interval
- Seizure disorder
- Sinusitis
- Skin and skin structure infection
- Skin rash
- Stridor
- Upper respiratory infection
- Urinary tract infection
- Urticaria
- Ventricular tachycardia
Less Severe
- Agitation
- Arthralgias
- Blurred vision
- Contact dermatitis
- Dental caries
- Dental discoloration
- Depression
- Diarrhea
- Dizziness
- Dyspepsia
- Dyspnea
- Earache
- Ecchymosis
- Eczema
- Eosinophilia
- Facial edema
- Fatigue
- Fever
- Hyperkinesis
- Insomnia
- Irritability
- Laryngitis
- Malaise
- Muscle rigidity
- Myalgias
- Nausea
- Oral candidiasis
- Paresthesia
- Pruritus of skin
- Rhinitis
- Rhinorrhea
- Skin rash
- Sore throat
- Symptoms of anxiety
- Toothache
- Urticaria
- Viral infection
- Vomiting
- Weight gain
- Xerostomia
Contraindicated
None
Severe Precaution
Glucocorticoid_LA-Beta Agonist
Safety and efficacy not established age<12 years. Do not use for acute asthma. Risk of decreased growth rate.
- 1 Day – 12 Years
- Safety and efficacy not established age<12 years. Do not use for acute asthma. Risk of decreased growth rate.
Management or Monitoring Precaution
Fluticasone (Select)
Risk of decreased growth velocity. Titrate to lowest effective dose and monitor growth
- 12 Years – 18 Years
- Risk of decreased growth velocity. Titrate to lowest effective dose and monitor growth
Fluticasone (inhal)
- Severity Level:
2
- Additional Notes: Current evidence supports use of inhaled corticosteroids for asthma tx in preg
Salmeterol
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Fluticasone (inhal, Nasal)
Systemic products excreted in rats; caution advised with nasal administration
Insufficient human studies data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Systemic products excreted in rats; caution advised with nasal administration |
Salmeterol
Systemic products excreted in rats; caution advised with nasal administration
Insufficient human studies data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human studies data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Fluticasone (inh)
Musculoskeletal-Use with caution in patients with osteoporosis. Decreases in bone mineral density (BMD) has been observed with long-term administration of products containing inhaled corticosteroids.
Cardiovascular-Use caution in severe cardiovascular diseases, particularly coronary insufficiency, since beta-agonists increase heart rate and blood pressure. Endocrine-Use caution in poorly controlled hyperthyroidism or diabetes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | Y |
BEERS: N HEDIS: N STOPP: N
Salmeterol
Musculoskeletal-Use with caution in patients with osteoporosis. Decreases in bone mineral density (BMD) has been observed with long-term administration of products containing inhaled corticosteroids.
Cardiovascular-Use caution in severe cardiovascular diseases, particularly coronary insufficiency, since beta-agonists increase heart rate and blood pressure. Endocrine-Use caution in poorly controlled hyperthyroidism or diabetes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | Y |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Maintenance therapy for asthma | |
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
| 0-9 | A-Z |
|---|---|
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
Formulary Reference Tool