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Drug overview for PERDIEM (sennosides):
Generic name: SENNOSIDES (SEN-oh-sides)
Drug class: Stimulant Laxatives
Therapeutic class: Gastrointestinal Therapy Agents
The anthraquinone group of stimulant laxatives includes the plant-derived compounds aloe (preparations containing aloe are no longer commercially available in the US), cascara sagrada (preparations containing cascara sagrada are no longer commercially available in the US), frangula, and senna.
No enhanced Uses information available for this drug.
Generic name: SENNOSIDES (SEN-oh-sides)
Drug class: Stimulant Laxatives
Therapeutic class: Gastrointestinal Therapy Agents
The anthraquinone group of stimulant laxatives includes the plant-derived compounds aloe (preparations containing aloe are no longer commercially available in the US), cascara sagrada (preparations containing cascara sagrada are no longer commercially available in the US), frangula, and senna.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for PERDIEM (sennosides) have been approved by the FDA:
Indications:
None.
Professional Synonyms:
None.
Indications:
None.
Professional Synonyms:
None.
The following dosing information is available for PERDIEM (sennosides):
No enhanced Dosing information available for this drug.
Anthraquinone laxatives are administered orally, usually in a single dose at bedtime.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| PERDIEM OVERNIGHT RLF 15 MG TB | Maintenance | Adults take 2 tablets (30 mg) by oral route once daily |
No generic dosing information available.
The following drug interaction information is available for PERDIEM (sennosides):
There are 0 contraindications.
There are 3 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Selected Bowel Preparations/Stimulant Laxatives SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Osmotic laxatives and stimulant laxatives may have additive adverse effects.(1) CLINICAL EFFECTS: Concurrent use of stimulant laxatives and Sutab tablets (sodium sulfate, magnesium sulfate, and potassium chloride) may increase the risk of mucosal ulceration, ischemic colitis, gastric ulcerations, or gastritis.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The manufacturer of Sutab tablets (sodium sulfate, magnesium sulfate and potassium chloride) recommends avoiding the use of stimulant laxatives while using this bowel preparation product.(1) DISCUSSION: Osmotic laxative products may produce colonic mucosal aphthous ulcerations which reports have shown can lead to ischemic colitis requiring hospitalization. Using stimulant laxatives in addition may increase this risk.(1) |
SUFLAVE, SUTAB |
| Trofinetide/Laxatives SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Trofinetide commonly causes diarrhea of mild to moderate severity. Laxatives may increase the incidence or severity of diarrhea.(1) CLINICAL EFFECTS: Concurrent use of laxatives with trofinetide may increase the risk of severe diarrhea.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Patients should stop laxatives before starting trofinetide. If diarrhea occurs, consider anti-diarrheal treatment and monitor hydration status. If severe diarrhea or dehydration occurs, interrupt, reduce dose, or discontinue trofinetide.(1) DISCUSSION: In clinical trials, 85% of patients on trofinetide developed diarrhea. Concurrent use of laxatives may increase this risk.(1) |
DAYBUE |
| Tenapanor/Laxatives; Stool Softeners SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Tenapanor commonly causes diarrhea of mild to moderate severity. Laxatives and stool softeners may increase the incidence or severity of diarrhea.(1) CLINICAL EFFECTS: Concurrent use of laxatives or stool softeners with tenapanor may increase the risk of severe diarrhea.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The US manufacturer of tenapanor states that patients should be instructed to avoid stool softeners and laxatives with tenapanor. If severe diarrhea occurs, tenapanor should be discontinued.(1) DISCUSSION: In clinical trials, 43-53% of CKD patients on dialysis treated with tenapanor developed diarrhea. Diarrhea usually occurred soon after treatment initiation and was severe in 5% of patients.(1) |
XPHOZAH |
There are 0 moderate interactions.
The following contraindication information is available for PERDIEM (sennosides):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 2 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Appendicitis |
| Gastrointestinal obstruction |
There are 0 severe contraindications.
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Fecal incontinence |
The following adverse reaction information is available for PERDIEM (sennosides):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 6 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Hypocalcemia Hypokalemia Metabolic acidosis Metabolic alkalosis Proteinuria Tetany |
There are 14 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Abdominal pain with cramps |
Diarrhea Eructation Nausea |
| Rare/Very Rare |
|---|
|
Allergic dermatitis Arthritis Cachexia Hematuria Melanosis of colon Osteomalacia Pruritus of skin Skin rash Urine discoloration Urticaria |
The following precautions are available for PERDIEM (sennosides):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for PERDIEM (sennosides):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for PERDIEM (sennosides)'s list of indications:
No ICD codes found for this drug.
No ICD codes found for this drug.
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