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Drug overview for PALFORZIA (peanut allergen powder-dnfp):
Generic name: PEANUT ALLERGEN POWDER-DNFP (PEE-nut)
Drug class: Allergenic Extract-Peanut
Therapeutic class: Biologicals
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: PEANUT ALLERGEN POWDER-DNFP (PEE-nut)
Drug class: Allergenic Extract-Peanut
Therapeutic class: Biologicals
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
PALFORZIA 6 MG (LEVEL 2)
PALFORZIA 12 MG (LEVEL 3)
PALFORZIA 80 MG (LEVEL 6)
PALFORZIA 120 MG (LEVEL 7)
PALFORZIA 200 MG (LEVEL 9)
PALFORZIA INITIAL DOSE PACK
The following indications for PALFORZIA (peanut allergen powder-dnfp) have been approved by the FDA:
Indications:
Peanut allergy
Professional Synonyms:
Allergy to peanuts
Indications:
Peanut allergy
Professional Synonyms:
Allergy to peanuts
The following dosing information is available for PALFORZIA (peanut allergen powder-dnfp):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| PALFORZIA 6 MG (LEVEL 2) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 12 MG (LEVEL 3) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 20 MG (LEVEL 4) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 40 MG (LEVEL 5) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 80 MG (LEVEL 6) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 120 MG (LEVEL 7) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 160 MG (LEVEL 8) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 200 MG (LEVEL 9) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 240 MG (LEVEL 10) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 300 MG (LEVEL 11) | Maintenance | Adults take 1 packet (300 mg) and sprinkle entire contents on small amount soft food then take by oral route once daily |
| PALFORZIA 300 MG (MAINTENANCE) | Maintenance | Adults take 1 packet (300 mg) and sprinkle entire contents on small amount soft food then take by oral route once daily |
| PALFORZIA 1 MG (LEVEL 0) | Maintenance | Adults take by oral route once daily per package directions |
| PALFORZIA 3 MG (LEVEL 1) | Maintenance | Adults take by oral route once daily per package directions |
No generic dosing information available.
The following drug interaction information is available for PALFORZIA (peanut allergen powder-dnfp):
There are 0 contraindications.
There are 1 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Allergen Immunotherapy/Beta-Blockers SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Beta-blockers may mask early signs and symptoms of anaphylaxis, make the treatment of anaphylaxis more difficult, and increase the severity of the reaction. CLINICAL EFFECTS: Beta-blockers may reduce a patient's ability to survive a systemic allergic reaction to allergen immunotherapy. Signs and symptoms of anaphylaxis may be masked. PREDISPOSING FACTORS: Concurrent use of epinephrine with beta-blockers may result in hypertension with reflex bradycardia. Epinephrine resistance in patients with anaphylaxis has been reported. PATIENT MANAGEMENT: Avoid concomitant administration of immunotherapy and beta-blockers if possible. If patients cannot safely discontinue beta-blockers but have a history of moderate to severe sting-induced anaphylaxis, venom immunotherapy is indicated because the risk of anaphylaxis related to a venom sting is greater than the risk of an immunotherapy-related systemic reaction. In patients taking beta-blockers for whom an acceptable alternative is not available, withholding allergen immunotherapy may be the best option. If both drugs are administered, monitor closely for signs and symptoms of anaphylaxis. Use caution when treating anaphylaxis with epinephrine since response may be poor. Epinephrine administration may worsen anaphylaxis because beta-blockers block the beta effects of epinephrine, which results in predomination of alpha effects. The plasma clearance of epinephrine is decreased. Glucagon may help in the treatment of refractory anaphylaxis in patients receiving beta-blockers. DISCUSSION: In a case report, a patient taking propranolol was administered pollen extract immunotherapy and immediately developed anaphylaxis. Treatment with epinephrine did not improve symptoms and patient was subsequently intubated.(2) In another case report, a patient taking propranolol was given pollen immunotherapy and developed anaphylaxis. Difficulty in maintaining an adequate blood pressure and pulse continued for several hours despite epinephrine and other supportive measures.(3) There are other case reports of patients taking propranolol with venom immunotherapy that were refractory to treatment.(6-7) |
ACEBUTOLOL HCL, ATENOLOL, ATENOLOL-CHLORTHALIDONE, BETAPACE, BETAPACE AF, BETAXOLOL HCL, BISOPROLOL FUMARATE, BISOPROLOL-HYDROCHLOROTHIAZIDE, BREVIBLOC, BYSTOLIC, CARVEDILOL, CARVEDILOL ER, COREG, COREG CR, ESMOLOL HCL, ESMOLOL HCL-SODIUM CHLORIDE, ESMOLOL HCL-WATER, HEMANGEOL, INDERAL LA, INDERAL XL, INNOPRAN XL, KAPSPARGO SPRINKLE, LABETALOL HCL, LABETALOL HCL-WATER, LOPRESSOR, METOPROLOL SUCCINATE, METOPROLOL TARTRATE, METOPROLOL-HYDROCHLOROTHIAZIDE, NADOLOL, NEBIVOLOL HCL, PINDOLOL, PROPRANOLOL HCL, PROPRANOLOL HCL ER, PROPRANOLOL-HYDROCHLOROTHIAZID, RAPIBLYK, SOTALOL, SOTALOL AF, SOTALOL HCL, SOTYLIZE, TENORETIC 100, TENORETIC 50, TENORMIN, TIMOLOL MALEATE, TOPROL XL |
There are 1 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Allergen Immunotherapy/Ustekinumab SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Ustekinumab may decrease the protective effect of allergen immunotherapy. CLINICAL EFFECTS: Ustekinumab may increase the risk of an allergic reaction to allergen immunotherapy. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Exercise caution in patients receiving or who have received allergen immunotherapy. Counsel patients on the possible increased risk of an allergic reaction.(1) DISCUSSION: Concurrent use of ustekinumab and allergen immunotherapy has not been evaluated.(1) |
IMULDOSA, OTULFI, PYZCHIVA, SELARSDI, STELARA, STEQEYMA, USTEKINUMAB, USTEKINUMAB-AEKN, USTEKINUMAB-TTWE, WEZLANA, YESINTEK |
The following contraindication information is available for PALFORZIA (peanut allergen powder-dnfp):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 1 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Eosinophilic esophagitis |
There are 1 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Asthma |
There are 0 moderate contraindications.
The following adverse reaction information is available for PALFORZIA (peanut allergen powder-dnfp):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 3 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Anaphylaxis Throat constriction |
Eosinophilic esophagitis |
| Rare/Very Rare |
|---|
| None. |
There are 14 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Acute abdominal pain Cough Dyspnea Ear itching Nausea Oral paresthesia Oral pruritus Pharyngitis Pruritus of skin Rhinorrhea Sneezing Urticaria Vomiting Wheezing |
None. |
| Rare/Very Rare |
|---|
| None. |
The following precautions are available for PALFORZIA (peanut allergen powder-dnfp):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for PALFORZIA (peanut allergen powder-dnfp):
WARNING: This product may cause a serious (rarely fatal) allergic reaction. This may occur at any time during treatment. Get medical help right away if you notice any symptoms of a serious allergic reaction, including: flushing, rash, itching/swelling (especially of the face, tongue, throat), severe dizziness, fainting, fast heartbeat, shortness of breath, or trouble breathing.
When you take this drug for the first time, and any time your dose is increased, you will need to stay in a health care setting (such as a doctor's office) for at least 60 minutes so your doctor can carefully monitor you and provide medical help if needed. People with worsening asthma are especially at risk for a serious allergic reaction. If you get worsening asthma symptoms, talk to your doctor right away before taking your dose of this medication.
Your doctor will also prescribe another medication (epinephrine) to use in case you have a serious allergic reaction outside the health care setting. Read the Patient Information Leaflet for this medication provided by your pharmacist. Learn ahead of time when and how to use your brand of epinephrine.
If you have to use it, get medical help as soon as you have used it. Also, some medications (including beta blockers such as atenolol) may make epinephrine or other rescue medications not work as well or increase your risk for side effects from these medications. Be sure to tell your doctor about all the drugs you use (including prescription/nonprescription drugs and herbal products).
To receive peanut allergen powder in the United States, you must understand, agree to, and carefully follow the requirements of the REMS Program for this medication. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
WARNING: This product may cause a serious (rarely fatal) allergic reaction. This may occur at any time during treatment. Get medical help right away if you notice any symptoms of a serious allergic reaction, including: flushing, rash, itching/swelling (especially of the face, tongue, throat), severe dizziness, fainting, fast heartbeat, shortness of breath, or trouble breathing.
When you take this drug for the first time, and any time your dose is increased, you will need to stay in a health care setting (such as a doctor's office) for at least 60 minutes so your doctor can carefully monitor you and provide medical help if needed. People with worsening asthma are especially at risk for a serious allergic reaction. If you get worsening asthma symptoms, talk to your doctor right away before taking your dose of this medication.
Your doctor will also prescribe another medication (epinephrine) to use in case you have a serious allergic reaction outside the health care setting. Read the Patient Information Leaflet for this medication provided by your pharmacist. Learn ahead of time when and how to use your brand of epinephrine.
If you have to use it, get medical help as soon as you have used it. Also, some medications (including beta blockers such as atenolol) may make epinephrine or other rescue medications not work as well or increase your risk for side effects from these medications. Be sure to tell your doctor about all the drugs you use (including prescription/nonprescription drugs and herbal products).
To receive peanut allergen powder in the United States, you must understand, agree to, and carefully follow the requirements of the REMS Program for this medication. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
The following icd codes are available for PALFORZIA (peanut allergen powder-dnfp)'s list of indications:
| Peanut allergy | |
| Z91.010 | Allergy to peanuts |
Formulary Reference Tool