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Drug overview for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
Generic name: GRASS POLLEN-ORCHARD/SWEET VERNAL/RYE/KENTUCKY/TIMOTHY, STD. (POL-uh-n)
Drug class: Allergenic Extract-Grass Pollens
Therapeutic class: Biologicals
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: GRASS POLLEN-ORCHARD/SWEET VERNAL/RYE/KENTUCKY/TIMOTHY, STD. (POL-uh-n)
Drug class: Allergenic Extract-Grass Pollens
Therapeutic class: Biologicals
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.) have been approved by the FDA:
Indications:
Allergic rhinitis due to grass pollen
Professional Synonyms:
Seasonal grass pollinosis
Indications:
Allergic rhinitis due to grass pollen
Professional Synonyms:
Seasonal grass pollinosis
The following dosing information is available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| ORALAIR 300 IR SUBLINGUAL TAB | Maintenance | Adults place 1 tablet under the tongue and allow to dissolve by sublingual route once daily |
| ORALAIR 300 IR STARTER PACK | Maintenance | Adults place 1 tablet under the tongue and allow to dissolve by sublingual route once daily |
| ORALAIR 300 IR ADULT SAMPLE KT | Maintenance | Adults place 1 tablet under the tongue and allow to dissolve by sublingual route once daily |
No generic dosing information available.
The following drug interaction information is available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
There are 0 contraindications.
There are 1 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Allergen Immunotherapy/Beta-Blockers SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Beta-blockers may mask early signs and symptoms of anaphylaxis, make the treatment of anaphylaxis more difficult, and increase the severity of the reaction. CLINICAL EFFECTS: Beta-blockers may reduce a patient's ability to survive a systemic allergic reaction to allergen immunotherapy. Signs and symptoms of anaphylaxis may be masked. PREDISPOSING FACTORS: Concurrent use of epinephrine with beta-blockers may result in hypertension with reflex bradycardia. Epinephrine resistance in patients with anaphylaxis has been reported. PATIENT MANAGEMENT: Avoid concomitant administration of immunotherapy and beta-blockers if possible. If patients cannot safely discontinue beta-blockers but have a history of moderate to severe sting-induced anaphylaxis, venom immunotherapy is indicated because the risk of anaphylaxis related to a venom sting is greater than the risk of an immunotherapy-related systemic reaction. In patients taking beta-blockers for whom an acceptable alternative is not available, withholding allergen immunotherapy may be the best option. If both drugs are administered, monitor closely for signs and symptoms of anaphylaxis. Use caution when treating anaphylaxis with epinephrine since response may be poor. Epinephrine administration may worsen anaphylaxis because beta-blockers block the beta effects of epinephrine, which results in predomination of alpha effects. The plasma clearance of epinephrine is decreased. Glucagon may help in the treatment of refractory anaphylaxis in patients receiving beta-blockers. DISCUSSION: In a case report, a patient taking propranolol was administered pollen extract immunotherapy and immediately developed anaphylaxis. Treatment with epinephrine did not improve symptoms and patient was subsequently intubated.(2) In another case report, a patient taking propranolol was given pollen immunotherapy and developed anaphylaxis. Difficulty in maintaining an adequate blood pressure and pulse continued for several hours despite epinephrine and other supportive measures.(3) There are other case reports of patients taking propranolol with venom immunotherapy that were refractory to treatment.(6-7) |
ACEBUTOLOL HCL, ATENOLOL, ATENOLOL-CHLORTHALIDONE, BETAPACE, BETAPACE AF, BETAXOLOL HCL, BISOPROLOL FUMARATE, BISOPROLOL-HYDROCHLOROTHIAZIDE, BREVIBLOC, BYSTOLIC, CARVEDILOL, CARVEDILOL ER, COREG, COREG CR, CORGARD, ESMOLOL HCL, ESMOLOL HCL-SODIUM CHLORIDE, ESMOLOL HCL-WATER, HEMANGEOL, INDERAL LA, INDERAL XL, INNOPRAN XL, KAPSPARGO SPRINKLE, LABETALOL HCL, LABETALOL HCL-WATER, LOPRESSOR, METOPROLOL SUCCINATE, METOPROLOL TARTRATE, METOPROLOL-HYDROCHLOROTHIAZIDE, NADOLOL, NEBIVOLOL HCL, PINDOLOL, PROPRANOLOL HCL, PROPRANOLOL HCL ER, PROPRANOLOL-HYDROCHLOROTHIAZID, RAPIBLYK, SOTALOL, SOTALOL AF, SOTALOL HCL, SOTYLIZE, TENORETIC 100, TENORETIC 50, TENORMIN, TIMOLOL MALEATE, TOPROL XL |
There are 1 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Allergen Immunotherapy/Ustekinumab SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Ustekinumab may decrease the protective effect of allergen immunotherapy. CLINICAL EFFECTS: Ustekinumab may increase the risk of an allergic reaction to allergen immunotherapy. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Exercise caution in patients receiving or who have received allergen immunotherapy. Counsel patients on the possible increased risk of an allergic reaction.(1) DISCUSSION: Concurrent use of ustekinumab and allergen immunotherapy has not been evaluated.(1) |
OTULFI, PYZCHIVA, SELARSDI, STELARA, STEQEYMA, USTEKINUMAB, USTEKINUMAB-AEKN, USTEKINUMAB-TTWE, WEZLANA, YESINTEK |
The following contraindication information is available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 2 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Eosinophilic esophagitis |
| Severe persistent asthma |
There are 6 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| 30 day risk period post-myocardial infarction |
| Invasive dental procedure |
| Life-threatening cardiac arrhythmias |
| Oral lichen planus |
| Stomatitis |
| Unstable angina pectoris |
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Severe uncontrolled hypertension |
The following adverse reaction information is available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 13 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Tongue swelling |
| Rare/Very Rare |
|---|
|
Altered consciousness Anaphylaxis Angioedema Asthma exacerbation Eosinophilia Eosinophilic esophagitis Exacerbation of ulcerative colitis Hashimoto thyroiditis Hypotension Laryngismus Oral lichen planus Throat constriction |
There are 41 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Cough Ear itching Edema of the oral soft tissue Mouth irritation Oral pruritus Pharyngitis Pruritis of tongue Sore throat |
Dysphagia |
| Rare/Very Rare |
|---|
|
Acute abdominal pain Cheilitis Chest discomfort Diarrhea Dizziness Drowsy Dysarthria Dyspepsia Earache Erythema Facial edema Flu-like symptoms Gastritis Hoarseness Hyperventilation Lymphadenopathy Oral hypoesthesia Palpitations Parotitis Periorbital edema Pneumonia Sialoadenitis Sialorrhea Stomatitis Stridor Tachycardia Tinnitus Tremor Urticaria Vomiting Wheezing Xerostomia |
The following precautions are available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.):
WARNING: Rarely, this medication can cause a serious (rarely fatal) allergic reaction. Get medical help right away if you notice any symptoms of a serious allergic reaction, including: flushing/rash, itching/swelling (especially of the face, tongue, throat), severe dizziness, fast/weak heartbeat, or trouble breathing. To be sure that you do not have a serious reaction, you will need to stay in a health care setting for 30 minutes after taking this drug for the first time so your doctor can carefully monitor you and provide medical help if needed.
Your doctor will also prescribe another medication (epinephrine) to use if you have a serious allergic reaction outside the health care setting. Read the Patient Information Leaflet for this medication provided by your pharmacist. Learn ahead of time when and how to use your brand of epinephrine, and get medical help right away if you have to use it.
Certain medical conditions may increase the seriousness of an allergic reaction or your risk for an allergic reaction. These include high blood pressure, breathing disorders such as asthma, or heart problems such as angina/irregular heartbeat/previous heart attack. Also, some medications (including beta blockers such as atenolol) may make epinephrine or other rescue medications not work as well or increase your risk for side effects from these medications. Be sure to tell your doctor about all the drugs you use (including prescription/nonprescription drugs and herbal products).
WARNING: Rarely, this medication can cause a serious (rarely fatal) allergic reaction. Get medical help right away if you notice any symptoms of a serious allergic reaction, including: flushing/rash, itching/swelling (especially of the face, tongue, throat), severe dizziness, fast/weak heartbeat, or trouble breathing. To be sure that you do not have a serious reaction, you will need to stay in a health care setting for 30 minutes after taking this drug for the first time so your doctor can carefully monitor you and provide medical help if needed.
Your doctor will also prescribe another medication (epinephrine) to use if you have a serious allergic reaction outside the health care setting. Read the Patient Information Leaflet for this medication provided by your pharmacist. Learn ahead of time when and how to use your brand of epinephrine, and get medical help right away if you have to use it.
Certain medical conditions may increase the seriousness of an allergic reaction or your risk for an allergic reaction. These include high blood pressure, breathing disorders such as asthma, or heart problems such as angina/irregular heartbeat/previous heart attack. Also, some medications (including beta blockers such as atenolol) may make epinephrine or other rescue medications not work as well or increase your risk for side effects from these medications. Be sure to tell your doctor about all the drugs you use (including prescription/nonprescription drugs and herbal products).
The following icd codes are available for ORALAIR (grass pollen-orchard/sweet vernal/rye/kentucky/timothy, std.)'s list of indications:
| Allergic rhinitis due to grass pollen | |
| J30.1 | Allergic rhinitis due to pollen |
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