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SINUS RELIEF PRESSURE-PAIN (guaifenesin/phenylephrine HCl/acetaminophen)
- Cold symptoms
- Cough
- Flu-like symptoms
- Nasal congestion
- Sinus headache
- Wal-phed Pe Triple Relief Tablet
- Tylenol Sinus Severe Tablet
- Tylenol Cold Head Congestion Severe Tablet
- Sudafed Pe Head Congestion-mucus Tablet
- Sinus Relief Severe Congestion Tablet
- Sinus Relief Pressure And Pain Tablet
- Sinus Congestion And Pain (guaifenesin) Tablet
- Severe Sinus Tablet
- Pressure-pain Pe Plus Mucus Tablet
- Mucus Relief Sinus Pressure And Pain Tablet
- Mucus Relief Severe Sinus Congestion Tablet
- Mucus Relief Cold And Sinus Tablet
- Mucinex Sinus-max Sev Congestion Tablet
- Mucinex Fast-max Cold-sinus Tablet
5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
Tylenol Cold Head Congestion Severe 5 mg-325 mg-200 mg tablet
- Dosage information is not available
Sudafed PE Head Congestion-Mucus 5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
Severe Congestion 5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
Pressure and Pain 5 mg-325 mg-200 mg tablet
- Dosage information is not available
Sinus Relief Pressure and Pain 5 mg-325 mg-200 mg tablet
- Dosage information is not available
Sinus Congestion and Pain (guaifenesin) 5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
Mucus Relief Sinus Pressure and Pain 5 mg-325 mg-200 mg tablet
- Dosage information is not available
Mucus Relief Severe Sinus Congestion 5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
Mucus Relief Cold and Sinus 5 mg-325 mg-200 mg tablet
- Dosage information is not available
Mucinex Sinus-Max Sev Congestion 5 mg-325 mg-200 mg tablet
- Dosage information is not available
5 mg-325 mg-200 mg tablet
- Dosage information is not available
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- Compound 347
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- isoflurane
- linezolid
- methylergonovine
- Migergot
- Migranal
- Parlodel
- rasagiline
- selegiline HCl
- sevoflurane
- Sojourn
- Terrell
- Ultane
- Zelapar
- Zyvox
Severe
Moderate
- Coumadin
- isoniazid
- isoniazid-rifamp-pyrazinamide
- Jantoven
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Rifamate
- rifampin-isoniazid
- Rifater
- warfarin
- Acetaminophen overdose
- Acute hepatic failure
- Acute hepatitis C
- Acute myocardial infarction
- Arterial thrombosis
- Severe uncontrolled hypertension
- Ventricular tachycardia
Contraindicated
- Acute hepatitis
- Acute pancreatitis
- Benign prostatic hyperplasia
- Bradycardia
- Coronary artery disease
- Disease of liver
- Hypertension
- Hyperthyroidism
- Incomplete AV heart block
- Protein-calorie malnutrition
- Severe arteriosclerotic vascular disease
- Severe renal impairment
- Shock
Severe
Moderate
- Acidosis
- Chronic heart failure
- Hypoxia
- No disease contraindications
SINUS RELIEF PRESSURE-PAIN (guaifenesin/phenylephrine HCl/acetaminophen)
- Cold symptoms
- Cough
- Flu-like symptoms
- Nasal congestion
- Sinus headache
- None
- None
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Acute hepatic failure
- Agranulocytosis
- Allergic dermatitis
- Angioedema
- Cardiac arrhythmia
- Dizziness
- Drug-induced hepatitis
- Headache disorder
- Hyperhidrosis
- Insomnia
- Laryngeal edema
- Leukopenia
- Maculopapular rash
- Nervousness
- Neutropenic disorder
- Pallor
- Stevens-johnson syndrome
- Tachycardia
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Tremor
Less Severe
- Erythema
- Gastrointestinal irritation
- Medication overuse headache
- Nausea
- Skin rash
- Urticaria
- Vomiting
Contraindicated
Phenylephrine (Oral,Rectal)
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
Severe Precaution
None
Management or Monitoring Precaution
Acetaminophen (oral,rectal)
Use weight based dosing in children less than 12 years.
Consult clinician for use in pediatrics age < 12 years.
- 1 Day – 12 Years
- Use weight based dosing in children less than 12 years.
Guaifenesin (solid dose form)
Use weight based dosing in children less than 12 years.
Consult clinician for use in pediatrics age < 12 years.
- 1 Day – 12 Years
- Consult clinician for use in pediatrics age < 12 years.
Acetaminophen
- Severity Level:
2
- Additional Notes: Available data suggest no known risk; otc product, no fda pregnancy warnings
Guaifenesin
- Severity Level:
C
- Additional Notes:
Phenylephrine
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Guaifenesin
Insufficient data available
Oral bioavailability low; infant exposure may be minimal
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Phenylephrine
Insufficient data available
Oral bioavailability low; infant exposure may be minimal
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Oral bioavailability low; infant exposure may be minimal |
No Known Risk
Acetaminophen
Low levels excreted with low risk for adverse effects in infant
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | No adverse effect | Low levels excreted with low risk for adverse effects in infant |
Contraindicated
None
Precaution Exists
Acetaminophen (oral,rectal)
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Phenylephrine
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| Flu-like symptoms | |
| J02.9 | Acute pharyngitis, unspecified |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R50.9 | Fever, unspecified |
| R53.1 | Weakness |
| R53.81 | Other malaise |
| R53.83 | Other fatigue |
| R68.83 | Chills (without fever) |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Sinus headache | |
| R51 | Headache |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J02.9 | Acute pharyngitis, unspecified |
| R05 | Cough |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R09.81 | Nasal congestion |
| R50.9 | Fever, unspecified |
| R51 | Headache |
| R53.1 | Weakness |
| R53.81 | Other malaise |
| R53.83 | Other fatigue |
| R68.83 | Chills (without fever) |
Formulary Reference Tool