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VOSEVI (SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 3
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 2
- Chronic hepatitis C - genotype 5
- Chronic hepatitis C - genotype 6
400 mg-100 mg-100 mg tablet
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 1
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 2
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 3
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 4
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 5
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
Chronic hepatitis C - genotype 6
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily with food
- Aptivus
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- Cold & Flu Fighter
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Epitol
- Equetro
- Fatigue Relief Complex
- fosphenytoin
- isoniazid-rifamp-pyrazinamide
- Luminal
- Mycobutin
- Mysoline
- oxcarbazepine
- Oxtellar Xr
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Priftin
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- St. John's wort
- Tegretol
- Tegretol Xr
- tipranavir
- Trileptal
- vit C-St. John wort-elder-hb30
- Women's Complex
Contraindicated
- Atripla
- efavirenz
- efavirenz-emtricitabin-tenofov
- Hycamtin
- Sustiva
- topotecan
Severe
Moderate
- afatinib
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Diamode
- Etopophos
- etoposide
- etoposide phosphate
- Gilotrif
- Imodium Multi-symptom Relief
- Lo-peramide
- loperamide
- loperamide-simethicone
- Toposar
- Ultra A-d
- Child-pugh class C hepatic impairment
- Hepatic failure
Contraindicated
- Child-pugh class B hepatic impairment
Severe
Moderate
- Reactivation of hepatitis B
VOSEVI (SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 3
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 2
- Chronic hepatitis C - genotype 5
- Chronic hepatitis C - genotype 6
- None
- Diarrhea
- Fatigue
- Headache disorder
- Nausea
More Frequent
Severe
Less Severe
- None
- Depression
- Dizziness
- Elevated serum lipase
- General weakness
- Hyperbilirubinemia
- Increased creatine kinase level
- Insomnia
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Angioedema
- Diabetes mellitus
- Hepatic failure
- Hypotension
- Leukopenia
- Peritonitis
- Reactivation of hepatitis B
Less Severe
- Abdominal distension
- Acute abdominal pain
- Blistering skin
- Constipation
- Contact dermatitis
- Dyspepsia
- Gastroesophageal reflux disease
- Palpitations
- Symptoms of anxiety
- Tremor
- Vertigo
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Sofosbuvir, velpatasvir
No established safety and efficacy established age < 18 years.
- 1 Day – 18 Years
- No established safety and efficacy established age < 18 years.
Sofosbuvir-velpatasvir-voxilaprevir
- Severity Level:
2
- Additional Notes: Insuff human data; animal data do not sug dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Sofosbuvir-velpatasvir-voxilaprev
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Although this medication helps many people with hepatitis C, it may cause people who also have another liver problem called hepatitis B to get worse. Before starting this medication, tell your doctor if you have ever had hepatitis B. Tell your doctor right away if you have new or worsening symptoms of liver disease, such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, dark urine or yellowing eyes/skin.
| Chronic hepatitis C - genotype 1 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 2 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 3 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 4 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 5 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 6 | |
| B18.2 | Chronic viral hepatitis C |
| 0-9 | A-Z |
|---|---|
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
Formulary Reference Tool