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VIREAD (TENOFOVIR DISOPROXIL FUMARATE)
- Chronic hepatitis B
- HIV infection
150 mg tablet
- Dosage information is not available
200 mg tablet
- Dosage information is not available
250 mg tablet
- Dosage information is not available
300 mg tablet
- 1 tablet (300 mg) by oral route once daily with a meal
40 mg/scoop (40 mg/gram) oral powder
- 7.5 scoops (300 mg) by oral route once daily added to 2 to 4 oz of applesauce, baby food or yogurt and stirred until completely mixed
150 mg tablet
- Dosage information is not available
200 mg tablet
- Dosage information is not available
250 mg tablet
- Dosage information is not available
300 mg tablet
- 1 tablet (300 mg) by oral route once daily with a meal
Chronic hepatitis B
- 1 tablet (300 mg) by oral route once daily with a meal
- 7.5 scoops (300 mg) by oral route once daily added to 2 to 4 oz of applesauce, baby food or yogurt and stirred until completely mixed
HIV infection
- 1 tablet (300 mg) by oral route once daily with a meal
- 7.5 scoops (300 mg) by oral route once daily added to 2 to 4 oz of applesauce, baby food or yogurt and stirred until completely mixed
- adefovir
- cidofovir
- Hepsera
- Vistide
Contraindicated
- None
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- atazanavir
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Daypro
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- didanosine
- Duexis
- Ec-naprosyn
- etodolac
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Incivek
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- ketoprofen
- ketorolac
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- oxaprozin
- Pennsaid
- piroxicam
- Ponstel
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- Reyataz
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- telaprevir
- tolmetin
- Vicoprofen
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zipsor
- Zorvolex
- Lactic acidosis
Contraindicated
- Acute renal failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Fanconi syndrome
- Hypophosphatemia
- Osteomalacia
- Pathological fracture
Severe
Moderate
- Kidney disease with likely reduction in GFR
- Osteopenia
VIREAD (TENOFOVIR DISOPROXIL FUMARATE)
- Chronic hepatitis B
- HIV infection
- Depression
- Skin rash
- Acute abdominal pain
- Back pain
- Cough
- Diarrhea
- Dizziness
- Fever
- Flatulence
- General weakness
- Headache disorder
- Insomnia
- Nausea
- Pain
- Pruritus of skin
- Vomiting
More Frequent
Severe
Less Severe
- Hypercholesterolemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Pneumonia
- Anorexia
- Arthralgias
- Chest pain
- Dyspepsia
- Fatigue
- Myalgias
- Pharyngitis
- Polyuria
- Proteinuria
- Sinusitis
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute renal failure
- Angioedema
- Dyspnea
- Fanconi syndrome
- Graves' disease
- Guillain-barre syndrome
- Hepatitis
- Hypokalemia
- Hypophosphatemia
- Interstitial nephritis
- Kidney disease with reduction in GFR
- Lactic acidosis
- Nephrogenic diabetes insipidus
- Osteomalacia
- Pancreatitis
- Peripheral neuropathy
- Polymyositis
- Renal tubular necrosis
- Rhabdomyolysis
- Steatosis of liver
Less Severe
- Hyperhidrosis
- Hypertriglyceridemia
- Muscle weakness
- Myopathy
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tenofovir
Safety and efficacy not established age < 2 years. Potential risk of osteomalacia.
Potential risk of decreased bone mineral density. Unknown effects on long-term bone health. Assess bone density with history of fractures or underlying bone loss.
- 1 Day – 2 Years
- Safety and efficacy not established age < 2 years. Potential risk of osteomalacia.
- Potential risk of decreased bone mineral density. Unknown effects on long-term bone health. Assess bone density with history of fractures or underlying bone loss.
- 2 Years – 18 Years
- Safety and efficacy not established age < 2 years. Potential risk of osteomalacia.
- Potential risk of decreased bone mineral density. Unknown effects on long-term bone health. Assess bone density with history of fractures or underlying bone loss.
Tenofovir
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tenofovir
Limited data suggest no known adverse effects in nursing infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest no known adverse effects in nursing infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tenofovir Disoproxil
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- If you have hepatitis B infection, your hepatitis symptoms may get worse or become very serious if you stop taking tenofovir. Talk with your doctor before stopping this medication. Your doctor will monitor liver tests for several months after you stop tenofovir. Tell your doctor right away if you develop symptoms of worsening liver problems.
| Chronic hepatitis B | |
| B18.0 | Chronic viral hepatitis B with delta-agent |
| B18.1 | Chronic viral hepatitis B without delta-agent |
| HIV infection | |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
| 0-9 | A-Z |
|---|---|
| B18.0 | Chronic viral hepatitis B with delta-agent |
| B18.1 | Chronic viral hepatitis B without delta-agent |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
Formulary Reference Tool