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CAPRELSA (VANDETANIB)
- Medullary thyroid carcinoma
100 mg tablet
- 3 tablets (300 mg) by oral route once daily
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
100 mg tablet
- 3 tablets (300 mg) by oral route once daily
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
Medullary thyroid carcinoma
- 1 tablet (300 mg) by oral route once daily
- 3 tablets (300 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- BCG vaccine, live (PF)
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- B cplx-C-St.Johnwrt-K.&S.ginsg
- bedaquiline
- Belladonna-phenobarbital
- Betapace
- Betapace Af
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- chloroquine phosphate
- chlorpromazine
- Cold & Flu Fighter
- Corvert
- dasatinib
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Diskets
- dofetilide
- Dolophine
- Donnatal
- enzalutamide
- Epitol
- Equetro
- escitalopram oxalate
- Fareston
- Fatigue Relief Complex
- fosphenytoin
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- Invega
- Invega Sustenna
- Invirase
- isoniazid-rifamp-pyrazinamide
- isradipine
- Lexapro
- Luminal
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Mysoline
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- paliperidone
- paliperidone palmitate
- pasireotide
- Pentam
- pentamidine
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- primidone
- procainamide
- propafenone
- Qualaquin
- quinine sulfate
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Rythmol
- saquinavir mesylate
- Signifor
- Sirturo
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- St. John's wort
- Tasigna
- Tegretol
- Tegretol Xr
- thioridazine
- Tikosyn
- toremifene
- Trisenox
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
Severe
Moderate
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- Anzemet
- asenapine
- Astagraf Xl
- budesonide-formoterol
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clozapine
- Clozaril
- dolasetron
- Dulera
- Effexor Xr
- Eovist
- eribulin
- Fazaclo
- felbamate
- Felbatol
- fingolimod
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadoxetate
- Geodon
- Gilenya
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Hecoria
- indapamide
- Istodax
- Kaletra
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- palonosetron
- pazopanib
- Perforomist
- posaconazole
- Prograf
- quetiapine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Saphris
- Saphris (black Cherry)
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Soltamox
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- telavancin
- telithromycin
- tetrabenazine
- tizanidine
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- Xenazine
- Zanaflex
- ziprasidone HCl
- ziprasidone mesylate
- Zofran
- Zofran Odt
- Zuplenz
- Arterial aneurysm
- Arterial dissection
- Congenital long QT syndrome
- Lactating mother
- Torsades de pointes
Contraindicated
- Cerebral ischemia
- Heart failure
- Hemorrhage
- Hypertension
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Hypothyroidism
- Interstitial lung disease
- Posterior reversible encephalopathy syndrome
- Pregnancy
- Prolonged QT interval
- Renal disease with moderate to severe impairment
- Severe diarrhea
Severe
Moderate
- None
CAPRELSA (VANDETANIB)
- Medullary thyroid carcinoma
- Hypertension
- Hypocalcemia
- Prolonged QT interval
- Acneiform eruption
- Acute abdominal pain
- Alopecia
- Anorexia
- Blurred vision
- Colitis
- Cough
- Depression
- Diarrhea
- Dry skin
- Dysgeusia
- Dyspepsia
- Fatigue
- Headache disorder
- Hypothyroidism
- Nausea
- Pharyngitis
- Proteinuria
- Skin rash
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Cardiac arrhythmia
- Cerebral ischemia
- Thrombocytopenic disorder
- Corneal opacity
- Muscle spasm
- Nail disorders
- Pruritus of skin
- Skin inflammation
- Skin photosensitivity
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Aspiration pneumonia
- Bacterial sepsis
- Heart failure
- Hemorrhage
- Interstitial lung disease
- Intestinal perforation
- Palmar-plantar erythrodysesthesia
- Pancreatitis
- Pneumonia
- Posterior reversible encephalopathy syndrome
- Stevens-johnson syndrome
- Torsades de pointes
- Toxic epidermal necrolysis
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Vandetanib
No pediatric safety and efficacy established.
- 1 Day – 18 Years
- No pediatric safety and efficacy established.
Vandetanib
- Severity Level:
D
- Additional Notes: Teratogenic and embryotoxic in animals at doses lower than human exposure doses
Contraindicated
Vandetanib
Insufficient human data available; serious side effects possible
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient human data available; serious side effects possible |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Vandetanib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting). Get medical help right away if you have any of these symptoms.<br /><br /> The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythm (see also Drug Interactions). Do not use vandetanib if you have a certain heart problem (long QT syndrome). Before using vandetanib, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation/long QT syndrome), family history of certain heart problems (QT prolongation/long QT syndrome, sudden cardiac death).<br /><br /> Vandetanib should not be used in people with low levels of calcium, potassium, or magnesium in the blood. Low levels of these minerals may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting.<br /><br /> To lower your risk, your doctor will check your mineral levels with a blood test and your heart with a test (EKG) before and periodically during treatment. Low mineral levels should be corrected before you start treatment. If you develop QT prolongation, your doctor may stop treatment for a while and restart it at a lower dose, and check your EKG again.<br /><br /> Since vandetanib stays in your body for a long time, it may take a while for side effects such as QT prolongation to go away after you stop taking it. Discuss the risks and benefits of treatment with your doctor. This medication is only available through a restricted program from certified prescribers and pharmacies called the Vandetanib REMS Program.<br /><br />These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
| Medullary thyroid carcinoma | |
| C73 | Malignant neoplasm of thyroid gland |
| E31.22 | Multiple endocrine neoplasia [MEn] type IIA |
| E31.23 | Multiple endocrine neoplasia [MEn] type IIB |
| 0-9 | A-Z |
|---|---|
| C73 | Malignant neoplasm of thyroid gland |
| E31.22 | Multiple endocrine neoplasia [MEn] type IIA |
| E31.23 | Multiple endocrine neoplasia [MEn] type IIB |
Formulary Reference Tool