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HEMLIBRA (EMICIZUMAB-KXWH)
- Bleeding prevention in hereditary factor VIII deficiency
105 mg/0.7 mL subcutaneous solution
- Dosage information is not available
150 mg/mL subcutaneous solution
- Dosage information is not available
30 mg/mL subcutaneous solution
- Dosage information is not available
60 mg/0.4 mL subcutaneous solution
- Dosage information is not available
Bleeding prevention in hereditary factor VIII deficiency
- Inject 3 mg/kg by subcutaneous route once weekly for 4 weeks in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 1.5 mg/kg by subcutaneous route once weekly in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 3 mg/kg by subcutaneous route once weekly for 4 weeks, followed by 1.5 mg/kg once weekly in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 3 mg/kg by subcutaneous route every 2 weeks in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 6 mg/kg by subcutaneous route every 4 weeks in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 3 mg/kg by subcutaneous route once weekly for 4 weeks, followed by 3 mg/kg every 2 weeks in the abdomen, thighs, or outer area of upper arm rotating injection sites
- Inject 3 mg/kg by subcutaneous route once weekly for 4 weeks, followed by 6 mg/kg every 4 weeks in the abdomen, thighs, or outer area of upper arm rotating injection sites
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- No disease contraindications
HEMLIBRA (EMICIZUMAB-KXWH)
- Bleeding prevention in hereditary factor VIII deficiency
- None
- Arthralgias
- Headache disorder
- Injection site sequelae
More Frequent
Severe
Less Severe
- Thromboembolic disorder
- Fever
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Dermal necrosis
- Rhabdomyolysis
- Thrombophlebitis
- Thrombotic thrombocytopenic purpura
Less Severe
- Myalgias
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Emicizumab-kxwh
- Severity Level:
2
- Additional Notes: Insufficient data available; assess risk vs. benefit
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Emicizumab-kxwh
Insuff data avail; consider maternal treatment benefit
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; consider maternal treatment benefit |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This medication has rarely caused serious blood clots (including thrombotic microangiopathy) when used along with another product used to treat or prevent bleeding (activated prothrombin complex concentrate-aPCC). The risk is higher when aPCC has been used for 24 hours or longer and the dose has reached a certain amount. Get medical help right away if you develop symptoms of serious blood clots, such as unusual decrease in the amount of urine, swelling ankles/feet, shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, weakness on one side of the body, sudden vision changes.
Bleeding prevention in hereditary factor VIII deficiency | |
D66 | Hereditary factor VIII deficiency |
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D66 | Hereditary factor VIII deficiency |
Formulary Reference Tool