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ALECENSA (ALECTINIB HYDROCHLORIDE)
- ALK positive non-small cell lung cancer
150 mg capsule
- 4 capsules (600 mg) by oral route 2 times per day
ALK positive non-small cell lung cancer
- 2 capsules (300 mg) by oral route 2 times per day
- 3 capsules (450 mg) by oral route 2 times per day
- 4 capsules (600 mg) by oral route 2 times per day
- None
Contraindicated
- None
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Acute renal failure
- Bradycardia
- Interstitial lung disease
- Myopathy with CK elevation
- Pregnancy
Severe
Moderate
- None
ALECENSA (ALECTINIB HYDROCHLORIDE)
- ALK positive non-small cell lung cancer
- Anemia
- Constipation
- Edema
- Fatigue
- Increased creatine kinase level
- Musculoskeletal pain
- Myalgias
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Bradycardia
- Hyperbilirubinemia
- Back pain
- Cough
- Diarrhea
- Dyspnea
- Headache disorder
- Nausea
- Skin rash
- Visual changes
- Vomiting
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Endocarditis
- Hemorrhage
- Hepatitis
- Interstitial lung disease
- Interstitial pneumonitis
- Intestinal perforation
- Kidney disease with reduction in GFR
- Pulmonary thromboembolism
Less Severe
- Skin photosensitivity
Contraindicated
None
Severe Precaution
Alectinib
No safety and efficacy. Potential risk of abnormal growth of bone and teeth.
- 1 Day – 18 Years
- No safety and efficacy. Potential risk of abnormal growth of bone and teeth.
Management or Monitoring Precaution
None
Alectinib
- Severity Level:
D
- Additional Notes: Based on pharmacology dev tox may occur; weigh maternal tx benefit vs fetal risk
Contraindicated
Alectinib
Insuff human data avail, potential for serious adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data avail, potential for serious adverse effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| ALK positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool