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SAVELLA (MILNACIPRAN HCL)
- Fibromyalgia
12.5 mg (5)-25 mg(8)-50mg(42) tablets in a dose pack
- Dosage information is not available
100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
12.5 mg tablet
- 2 tablets (25 mg) by oral route 2 times per day
25 mg tablet
- 2 tablets (50 mg) by oral route 2 times per day
50 mg tablet
- 2 tablets (100 mg) by oral route 2 times per day
Fibromyalgia
- 2 tablets (25 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Coumadin
- Demerol
- Demerol (pf)
- Jantoven
- meperidine
- meperidine (PF)
- Meperitab
- metoclopramide HCl
- Metozolv Odt
- Reglan
- warfarin
Severe
Moderate
- abciximab
- Abstral
- Actiq
- Activase
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Adderall
- Adderall Xr
- Adipex-p
- Adult Low Dose Aspirin
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aggrastat In Sodium Chloride
- Aggrenox
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- almotriptan malate
- Alsuma
- alteplase
- Amerge
- Amphetamine Salt Combo
- Anacin
- Anacin Maximum Strength
- Analgesic
- Anaprox
- Anaprox Ds
- Ansaid
- Antacid & Pain Relief
- Arthri-flex
- Arthrotec 50
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-81
- Aspir-low
- Aspir-trin
- aspirin
- Aspirin Childrens
- Aspirin Low Dose
- Aspirin Low-strength
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-calcium carbonate
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Axert
- Back & Body Pain Reliever
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Chewable Aspirin
- Bayer Childrens Aspirin
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Brilinta
- Buffered Aspirin
- Bufferin
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- Caldolor
- Cambia
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- Cataflam
- Celebrex
- celecoxib
- Child Aspirin
- Child Ibuprofen
- Children's Advil
- Children's Aspirin
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-DM-aspirin
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- chlorphenir-phenylephrn-aspirn
- cilostazol
- clopidogrel
- codeine-butalbital-ASA-caff
- Cold & Sinus Pain Relief
- Cold Relief
- Cold Relief Plus
- Cold-sinus Relief
- Conzip
- Daypro
- Desoxyn
- Dexedrine Spansule
- dextroamphetamine
- dextroamphetamine-amphetamine
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- dihydrocodeine-aspirin-caff
- dipyridamole-aspirin
- doxylamine-phenylep-DM-aspirin
- Duexis
- Duragesic
- E.c. Prin
- Ec-naprosyn
- Ecotrin
- Ecotrin Low Strength
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- eletriptan HBr
- Endodan
- Enteric Coated Aspirin
- eptifibatide
- etodolac
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Feldene
- fenoprofen
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Fiorinal
- Fiorinal-codeine #3
- Flanax
- Flector
- flurbiprofen
- Frova
- frovatriptan
- gluc-msm-coll2-hyal-antiarthr3
- glucos-msm-C-Mn-ginger-willow
- glucos-msm-C-Mn-herb#21
- glucos-msm-collagen-C-Mn-hrb21
- Glucosamine-msm Complex
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Imitrex
- Imitrex Statdose Kit Refill
- Imitrex Statdose Pen
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- ketoprofen
- ketorolac
- Lazanda
- Levacet
- levmetamfetamine
- lisdexamfetamine
- Lite Coat Aspirin
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-dose Aspirin
- Maxalt
- Maxalt-mlt
- Medi-profen
- Medi-seltzer
- Mediproxen
- mefenamic acid
- meloxicam
- methamphetamine
- Midol (naproxen)
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- Mobic
- Motrin Ib
- Motrin Pm
- Msm Glucosamine Complex
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- naratriptan
- Neoprofen (ibuprofen Lysn)(pf)
- Nucynta
- Nucynta Er
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxaprozin
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Pennsaid
- Percodan
- phentermine
- phentermine-topiramate
- piroxicam
- Plavix
- Pletal
- Ponstel
- Procentra
- Provil
- pseudoephedrine-ibuprofen
- Qsymia
- Relpax
- Reopro
- Reprexain
- Retavase
- reteplase
- rizatriptan
- Sinus & Cold-d
- Solaraze
- Sprix
- St Joseph Aspirin
- St. Joseph Aspirin
- Sublimaze (pf)
- Subsys
- sulindac
- sumatriptan
- sumatriptan succinate
- Sumavel Dosepro
- Super Pain Relief
- Suprenza
- Synalgos-dc
- Synapryn
- tapentadol
- tenecteplase
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- Tnkase
- tolmetin
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Tri-buffered Aspirin
- Ultracet
- Ultram
- Ultram Er
- Vanquish
- Vapor Inhaler
- Vicoprofen
- Vimovo
- Voltaren-xr
- Vyvanse
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Women's Aspirin With Calcium
- Zenzedi
- Zipsor
- zolmitriptan
- Zomig
- Zomig Zmt
- Zorvolex
- Serotonin syndrome
Contraindicated
- Abnormal hepatic function tests
- Alcoholism
- Angle-closure glaucoma
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Disease of liver
- Risk of angle-closure glaucoma due to narrow angle
- Sinus tachycardia
- Suicidal ideation
Severe
Moderate
- Hypertension
- Hypomania
- Hyponatremia
- Increased risk of bleeding
- Manic disorder
- Seizure disorder
- SIADH syndrome
- Urinary tract obstructive uropathy
SAVELLA (MILNACIPRAN HCL)
- Fibromyalgia
- None
- Constipation
- Dizziness
- Flushing
- Headache disorder
- Hyperhidrosis
- Hypertension
- Insomnia
- Nausea
- Palpitations
- Tachycardia
- Xerostomia
More Frequent
Severe
Less Severe
- None
- Acute abdominal pain
- Anorexia
- Blurred vision
- Chills
- Disorder of ejaculation
- Dysuria
- Migraine
- Skin rash
- Testicular pain
- Tremor
- Urinary hesitancy
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Acute renal failure
- Angina
- Ataxia
- Cystitis
- Ecchymosis
- Erythema multiforme
- Extrapyramidal disease
- Hallucinations
- Hemorrhage
- Hepatitis
- Homicidal ideation
- Hyperreflexia
- Hypertensive crisis
- Hyponatremia
- Leukopenia
- Manic disorder
- Myoclonus
- Neutropenic disorder
- Panic disorder
- Parkinsonism
- Peripheral edema
- Prostatitis
- Rhabdomyolysis
- Secondary angle-closure glaucoma
- Seizure disorder
- Serotonin syndrome
- SIADH syndrome
- Stevens-johnson syndrome
- Suicidal ideation
- Supraventricular premature beats
- Supraventricular tachycardia
- Takotsubo cardiomyopathy
- Thrombocytopenic disorder
- Ventricular premature beats
Less Severe
- Abdominal distension
- Aggressive behavior
- Bruxism
- Chest pain
- Conjunctival hemorrhage
- Delirium
- Depression
- Diarrhea
- Drowsy
- Dry eye
- Dry skin
- Dysgeusia
- Dyspepsia
- Dyspnea
- Epistaxis
- Erectile dysfunction
- Fatigue
- Fever
- Flatulence
- Galactorrhea not associated with childbirth
- Gastroesophageal reflux disease
- Hematuria
- Hypercholesterolemia
- Hyperprolactinemia
- Hypomania
- Increased urinary frequency
- Irritability
- Libido changes
- Mydriasis
- Night sweats
- Paresthesia
- Polydipsia
- Proteinuria
- Pruritus of skin
- Syncope
- Urinary retention
- Urinary tract infection
- Urticaria
- Yawning
Contraindicated
None
Severe Precaution
Milnacipran
Possible increased suicidal ideation and attempt. Not approved or recommended for pediatric use.
- 1 Day – 18 Years
- Possible increased suicidal ideation and attempt. Not approved or recommended for pediatric use.
Management or Monitoring Precaution
None
Milnacipran
- Severity Level:
C
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Milnacipran
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Milnacipran
Endocrine-Increased risk of hyponatremia and SIADH which may increase fall risk. Renal-Decrease dose by 50% for CrCL less than 30 mL/min. Cardiovascular-May elevate blood pressure and increase heart rate. Caution with underlying cardiovascular disease.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Although not used for depression, this medication is in the same class as antidepressant medications. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits.<br /><br />However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
| Fibromyalgia | |
| M79.7 | Fibromyalgia |
| 0-9 | A-Z |
|---|---|
| M79.7 | Fibromyalgia |
Formulary Reference Tool