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NOCDURNA (desmopressin acetate)
- Nocturia
- Nocdurna (women) Disintegrating Tablet,sublingual
- Nocdurna (men) Disintegrating Tablet,sublingual
- By Indication
(women) 27.7 mcg disintegrating tablet,sublingual
- Place 1 tablet (27.7 mcg) under the tongue and allow to dissolve by sublingual route once daily 1 hour before bedtime (for female)
(men) 55.3 mcg disintegrating tablet,sublingual
- Place 1 tablet (55.3 mcg) under the tongue and allow to dissolve by sublingual route once daily 1 hour before bedtime (for male)
Nocturia
- Place 1 tablet (27.7 mcg) under the tongue and allow to dissolve by sublingual route once daily 1 hour before bedtime (for female)
- Place 1 tablet (55.3 mcg) under the tongue and allow to dissolve by sublingual route once daily 1 hour before bedtime (for male)
- None
Contraindicated
- None
Severe
Moderate
- None
- Hyponatremia
- Renal disease with moderate to severe impairment
Contraindicated
- Psychogenic polydipsia
Severe
Moderate
- Chronic heart failure
- Coronary artery disease
- Cystic fibrosis
- Hypertension
- Water intoxication
NOCDURNA (desmopressin acetate)
- Nocturia
- None
- None
More Frequent
Severe
Less Severe
- None
- Abdominal pain with cramps
- Headache disorder
- Nausea
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Hypertension
- Hyponatremia
- Hypotension
- Seizure disorder
- Water intoxication
Less Severe
- Diarrhea
- Disturbance in thinking
- Flushing
- Vulvodynia
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Desmopressin (select)
Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
- 1 Day – 18 Years
- Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
Desmopressin Acetate
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Desmopressin
Limited data suggest negligible amount in breastmilk and poor oral absorption
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | Limited data suggest negligible amount in breastmilk and poor oral absorption |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Desmopressin can rarely cause a low level of sodium in the blood (hyponatremia), which can be serious or even fatal. Drinking too much liquid, using certain medications (such as glucocorticoids such as prednisone, "water pills"/diuretics including furosemide), being 65 years or older, or having certain medical conditions may increase the risk of low sodium in the blood. Lab tests (such as urine tests, sodium blood levels) must be done before you start using this medication and while you are using it.<br /><br />Keep all medical and lab appointments. Tell your doctor right away if you develop symptoms of low sodium in the blood, such as nausea, vomiting, headache, muscle weakness/cramps, unusual tiredness, unusual drowsiness, dizziness, restlessness, mental/mood changes including confusion/irritability. Get medical help right away if you have any very serious side effects, including seizure or trouble breathing.
| Nocturia | |
| R35.1 | Nocturia |
| 0-9 | A-Z |
|---|---|
| R35.1 | Nocturia |
Formulary Reference Tool